Publication Information

{'id': 'https://openalex.org/W2155045091', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-4992', 'title': 'Abstract 4992: Zkscan3 facilitates invasion of colorectal cancer associated with ceacam5', 'display_name': 'Abstract 4992: Zkscan3 facilitates invasion of colorectal cancer associated with ceacam5', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W2155045091', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-4992', 'mag': '2155045091'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-4992', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063137841', 'display_name': 'Seon Ae Roh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801680663', 'display_name': 'Asan Medical Center', 'ror': 'https://ror.org/03s5q0090', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801680663']}, {'id': 'https://openalex.org/I40542001', 'display_name': 'University of Ulsan', 'ror': 'https://ror.org/02c2f8975', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I40542001']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Seon A. Roh', 'raw_affiliation_strings': ['University of Ulsan Asan Medical Center, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'University of Ulsan Asan Medical Center, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2801680663', 'https://openalex.org/I40542001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014278842', 'display_name': 'Chan Wook Kim', 'orcid': 'https://orcid.org/0000-0002-2382-0939'}, 'institutions': [{'id': 'https://openalex.org/I2801680663', 'display_name': 'Asan Medical Center', 'ror': 'https://ror.org/03s5q0090', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801680663']}, {'id': 'https://openalex.org/I40542001', 'display_name': 'University of Ulsan', 'ror': 'https://ror.org/02c2f8975', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I40542001']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Chan Wook Kim', 'raw_affiliation_strings': ['University of Ulsan Asan Medical Center, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'University of Ulsan Asan Medical Center, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2801680663', 'https://openalex.org/I40542001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030188861', 'display_name': 'Ka Hee Tak', 'orcid': 'https://orcid.org/0000-0002-9440-1598'}, 'institutions': [{'id': 'https://openalex.org/I2801680663', 'display_name': 'Asan Medical Center', 'ror': 'https://ror.org/03s5q0090', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801680663']}, {'id': 'https://openalex.org/I40542001', 'display_name': 'University of Ulsan', 'ror': 'https://ror.org/02c2f8975', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I40542001']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ka Hee Tak', 'raw_affiliation_strings': ['University of Ulsan Asan Medical Center, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'University of Ulsan Asan Medical Center, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2801680663', 'https://openalex.org/I40542001']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052199736', 'display_name': 'Jin Cheon Kim', 'orcid': 'https://orcid.org/0000-0003-4823-8619'}, 'institutions': [{'id': 'https://openalex.org/I2801680663', 'display_name': 'Asan Medical Center', 'ror': 'https://ror.org/03s5q0090', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801680663']}, {'id': 'https://openalex.org/I40542001', 'display_name': 'University of Ulsan', 'ror': 'https://ror.org/02c2f8975', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I40542001']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jin Cheon Kim', 'raw_affiliation_strings': ['University of Ulsan Asan Medical Center, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'University of Ulsan Asan Medical Center, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2801680663', 'https://openalex.org/I40542001']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.399361, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': '4992', 'last_page': '4992'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9607, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9556, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lymphovascular-invasion', 'display_name': 'Lymphovascular invasion', 'score': 0.45364192}], 'concepts': [{'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.7613725}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.75352037}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5978986}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.48801342}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47297087}, {'id': 'https://openalex.org/C2778740770', 'wikidata': 'https://www.wikidata.org/wiki/Q6708283', 'display_name': 'Lymphovascular invasion', 'level': 4, 'score': 0.45364192}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.4137783}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.40235406}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3955174}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39368638}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.389026}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-4992', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4306404900', 'https://openalex.org/W4248366929', 'https://openalex.org/W4229832877', 'https://openalex.org/W4200211768', 'https://openalex.org/W3111812619', 'https://openalex.org/W3032784534', 'https://openalex.org/W3030972949', 'https://openalex.org/W2590035663', 'https://openalex.org/W2566344969', 'https://openalex.org/W1991898744'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose:': [1], 'ZKSCAN3': [2, 28, 150, 156, 165, 181, 201, 211, 236, 249, 265, 286, 299, 314, 323], 'is': [3, 315], 'over-expressed': [4], 'in': [5, 29, 159, 169, 224, 260, 285, 305], 'invasive': [6, 30], 'colonic': [7], 'tumor': [8, 18, 129, 262, 319, 325], 'cells': [9, 162, 174, 302], 'and': [10, 40, 52, 76, 98, 102, 111, 118, 131, 142, 164, 195, 226, 246, 248, 258, 272, 295, 321], 'regulate': [11], 'the': [12, 25, 85, 170, 298, 362, 367], 'expression': [13, 221, 279], 'of': [14, 27, 82, 87, 180, 190, 200, 297, 329, 352, 361, 366], 'several': [15], 'genes': [16, 127], 'favoring': [17], 'progression': [19, 320], 'including': [20], 'integrin': [21, 138, 143, 243, 273], 'β4.': [22], 'We': [23, 106], 'evaluated': [24], 'role': [26], 'signaling': [31], 'pathway': [32], 'with': [33, 96, 185, 208, 217, 241, 254, 270, 317, 333, 356], 'stage': [34], '4': [35], 'colorectal': [36, 318, 330, 353], 'cancer': [37, 331, 354], '(CRC).': [38], 'Materials': [39], 'methods:': [41], '119': [42], 'metastatic': [43, 160, 234, 261], 'CRC': [44, 55, 100, 103, 120, 161, 173], '(mCRC)': [45], 'patients': [46, 56, 94, 117], 'who': [47, 57], 'palliatively': [48], 'or': [49], 'curatively': [50, 58], 'resected': [51, 59], '331': [53], 'sporadic': [54], 'from': [60, 233], 'January': [61], '2004': [62], 'to': [63, 68, 267, 275], 'December': [64], '2009': [65], 'were': [66, 231, 239, 252], 'used': [67], 'identify': [69], 'correlations': [70], 'between': [71], 'single-nucleotide': [72], 'polymorphism': [73], '(SNP)': [74], 'rs733743': [75, 182, 202], 'clinically': [77], 'prognostic': [78], 'parameters.': [79], 'To': [80, 145], 'validation': [81], 'prior': [83], 'correlation,': [84], 'genotypes': [86], 'SNP': [88], 'identified': [89], 'by': [90, 155], 'pyrosequencing': [91], 'using': [92, 203], '81': [93], '(33': [95], 'mCRC': [97, 116], '48': [99], 'patients)': [101], 'cell': [104, 228, 289], 'lines.': [105], 'then': [107], 'performed': [108], 'immunohistochemistry': [109], '(IHC)': [110], 'Western': [112], 'blot': [113], 'on': [114], '36': [115], '49': [119], 'patients.': [121], 'Up-regulated': [122], 'putative': [123], 'down-stream': [124], 'targets': [125], 'included': [126], 'contributing': [128], 'aggressiveness': [130], 'invasiveness;': [132], 'VEGF,': [133, 245, 256], 'cyclin': [134], 'D2,': [135], 'Akt,': [136], 'phospho-Akt,': [137], 'β4,': [139, 244], 'KRAS,': [140], 'CEACAM5,': [141], 'α5β1.': [144], 'test': [146], 'biological': [147], 'utility': [148], 'assay,': [149], 'mRNA': [151], 'was': [152, 167, 183, 206, 215, 222, 280, 303], 'knocked': [153], 'down': [154], 'specific': [157], 'siRNA': [158], '(LOVO)': [163], 'cDNA': [166], 'overexpressed': [168, 300], 'low-ZKSCAN3': [171], 'expressed': [172], '(HCT116).': [175], 'Results:': [176], 'Wild-type': [177], 'alleles': [178, 199], '(GG)': [179], 'related': [184, 207, 216, 240, 253, 269, 316], 'male': [186], 'dominant,': [187], 'family': [188], 'history': [189], 'malignancy,': [191], 'high': [192, 237], 'CEA': [193, 271, 278, 306], 'concentration,': [194], 'mCRC.': [196], 'The': [197], 'wild-type': [198], 'tissue': [204, 214], 'sample': [205], 'lymphvascular': [209], 'invasion.': [210, 219, 322], 'IHC': [212], 'positive': [213], 'lymphovascular': [218], 'ZKSCAN': [220], 'higher': [223, 304], 'LOVO': [225, 288], 'SW620': [227], 'lines': [229], 'which': [230], 'derived': [232], 'site.': [235], 'groups': [238, 251], 'CEA,': [242], 'AKT': [247], 'low': [250], 'RAS,': [255], 'AKT,': [257], 'PAKT': [259], 'tissue.': [263], 'Therefore,': [264], 'seemed': [266], 'be': [268], 'β4': [274], 'metastasis.': [276], 'Additional': [277], 'observed': [281], 'a': [282], 'significant': [283], 'decrease': [284], 'knockdowned': [287], '(1.0': [290], 'vs': [291, 310], '0.89,': [292], 'P=': [293], '0.046)': [294], 'invasiveness': [296], 'HCT116': [301], 'coated': [307], 'filters': [308], '(75.6±6.0': [309], '91.3±4.5,': [311], 'P=0.023).': [312], 'Conclusion:': [313], 'overexpression': [324], 'may': [326], 'facilitate': [327], 'metastasis': [328], 'associated': [332, 355], 'CEACAM5.': [334], 'Citation': [335], 'Format:': [336], 'Seon': [337], 'Ae': [338], 'Roh,': [339], 'Chan': [340], 'Wook': [341], 'Kim,': [342], 'Ka': [343], 'Hee': [344], 'Tak,': [345], 'Jin': [346], 'Cheon': [347], 'Kim.': [348], 'Zkscan3': [349], 'facilitates': [350], 'invasion': [351], 'ceacam5.': [357], '[abstract].': [358], 'In:': [359], 'Proceedings': [360], '105th': [363], 'Annual': [364], 'Meeting': [365], 'American': [368], 'Association': [369], 'for': [370], 'Cancer': [371, 382], 'Research;': [372], '2014': [373], 'Apr': [374], '5-9;': [375], 'San': [376], 'Diego,': [377], 'CA.': [378], 'Philadelphia': [379], '(PA):': [380], 'AACR;': [381], 'Res': [383], '2014;74(19': [384], 'Suppl):Abstract': [385], 'nr': [386], '4992.': [387], 'doi:10.1158/1538-7445.AM2014-4992': [388]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155045091', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-08T15:20:47.445605', 'created_date': '2016-06-24'}