Publication Information

{'id': 'https://openalex.org/W2153588135', 'doi': 'https://doi.org/10.1073/pnas.160258197', 'title': 'Engineering blood meal-activated systemic immunity in the yellow fever mosquito, <i>Aedes aegypti</i>', 'display_name': 'Engineering blood meal-activated systemic immunity in the yellow fever mosquito, <i>Aedes aegypti</i>', 'publication_year': 2000, 'publication_date': '2000-07-25', 'ids': {'openalex': 'https://openalex.org/W2153588135', 'doi': 'https://doi.org/10.1073/pnas.160258197', 'mag': '2153588135', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10908672', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/16836'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.160258197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.160258197', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018952470', 'display_name': 'Vladimir Kokoza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Vladimir Kokoza', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038402409', 'display_name': 'Abduelaziz Ahmed', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Abduelaziz Ahmed', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021884175', 'display_name': 'Wen-Long Cho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Wen-Long Cho', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060540391', 'display_name': 'Nijole Jasinskiene', 'orcid': 'https://orcid.org/0000-0002-0862-0349'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Nijole Jasinskiene', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039756363', 'display_name': 'Anthony A. James', 'orcid': 'https://orcid.org/0000-0001-5577-3308'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Anthony A. James', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015114019', 'display_name': 'Alexander S. Raikhel', 'orcid': 'https://orcid.org/0000-0001-6361-813X'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW', 'US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Raikhel', 'raw_affiliation_strings': ['Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824; Department of Parasitology, National Yang-Ming University, 112 Taipei, Taiwan; and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697', 'institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I204250578', 'https://openalex.org/I148366613']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.393, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 183, 'citation_normalized_percentile': {'value': 0.99986, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '97', 'issue': '16', 'first_page': '9144', 'last_page': '9149'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11403', 'display_name': 'Invertebrate Immune Response Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11403', 'display_name': 'Invertebrate Immune Response Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12134', 'display_name': 'Insect symbiosis and bacterial influences', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cecropin', 'display_name': 'Cecropin', 'score': 0.7343272}, {'id': 'https://openalex.org/keywords/hemolymph', 'display_name': 'Hemolymph', 'score': 0.54064775}, {'id': 'https://openalex.org/keywords/blood-meal', 'display_name': 'Blood meal', 'score': 0.5140656}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.83436817}, {'id': 'https://openalex.org/C2777775583', 'wikidata': 'https://www.wikidata.org/wiki/Q1148004', 'display_name': 'Aedes aegypti', 'level': 3, 'score': 0.82421446}, {'id': 'https://openalex.org/C2777366737', 'wikidata': 'https://www.wikidata.org/wiki/Q24784723', 'display_name': 'Cecropin', 'level': 4, 'score': 0.7343272}, {'id': 'https://openalex.org/C2776498113', 'wikidata': 'https://www.wikidata.org/wiki/Q412820', 'display_name': 'Defensin', 'level': 3, 'score': 0.6685593}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.65800166}, {'id': 'https://openalex.org/C100068826', 'wikidata': 'https://www.wikidata.org/wiki/Q485675', 'display_name': 'Hemolymph', 'level': 2, 'score': 0.54064775}, {'id': 'https://openalex.org/C2777923404', 'wikidata': 'https://www.wikidata.org/wiki/Q886705', 'display_name': 'Blood meal', 'level': 2, 'score': 0.5140656}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.44419956}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.4306685}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37563378}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.3672406}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3252863}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25374055}, {'id': 'https://openalex.org/C540938839', 'wikidata': 'https://www.wikidata.org/wiki/Q1201508', 'display_name': 'Antimicrobial peptides', 'level': 3, 'score': 0.17935646}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.10886127}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.060682565}, {'id': 'https://openalex.org/C90856448', 'wikidata': 'https://www.wikidata.org/wiki/Q431', 'display_name': 'Zoology', 'level': 1, 'score': 0.059230506}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030801', 'descriptor_name': 'Animals, Genetically Modified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001769', 'descriptor_name': 'Blood', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004199', 'descriptor_name': 'Disease Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014819', 'descriptor_name': 'Vitellogenins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014819', 'descriptor_name': 'Vitellogenins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015005', 'descriptor_name': 'Yellow fever virus', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D015005', 'descriptor_name': 'Yellow fever virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.160258197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc16836', 'pdf_url': 'https://europepmc.org/articles/pmc16836?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16836', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10908672', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.160258197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W148629624', 'https://openalex.org/W1515263459', 'https://openalex.org/W1587430592', 'https://openalex.org/W1969163610', 'https://openalex.org/W1969584390', 'https://openalex.org/W1970087350', 'https://openalex.org/W1976627008', 'https://openalex.org/W1993097572', 'https://openalex.org/W1995362867', 'https://openalex.org/W2005863717', 'https://openalex.org/W2007397252', 'https://openalex.org/W2017339210', 'https://openalex.org/W2018624477', 'https://openalex.org/W2021554028', 'https://openalex.org/W2024367691', 'https://openalex.org/W2036117834', 'https://openalex.org/W2053350421', 'https://openalex.org/W2064041379', 'https://openalex.org/W2065613928', 'https://openalex.org/W2075787303', 'https://openalex.org/W2080199931', 'https://openalex.org/W2082816655', 'https://openalex.org/W2144634347', 'https://openalex.org/W2144721986', 'https://openalex.org/W2154337154', 'https://openalex.org/W2314225431', 'https://openalex.org/W2535533', 'https://openalex.org/W36862394', 'https://openalex.org/W39988843'], 'related_works': ['https://openalex.org/W4221027515', 'https://openalex.org/W2639201079', 'https://openalex.org/W2575974099', 'https://openalex.org/W2320081908', 'https://openalex.org/W2071730056', 'https://openalex.org/W2066395430', 'https://openalex.org/W1997081253', 'https://openalex.org/W1982037500', 'https://openalex.org/W1972130812', 'https://openalex.org/W1045998074'], 'abstract_inverted_index': {'Progress': [0], 'in': [1, 45, 108, 144, 226], 'molecular': [2, 217], 'genetics': [3], 'makes': [4], 'possible': [5], 'the': [6, 15, 24, 28, 61, 64, 74, 91, 96, 109, 128, 133, 145, 184, 199, 214, 221], 'development': [7, 215], 'of': [8, 17, 27, 34, 63, 73, 81, 132, 139, 147, 169, 192, 216, 223], 'alternative': [9], 'disease': [10], 'control': [11, 175, 222], 'strategies': [12], 'that': [13, 95, 168], 'target': [14], 'competence': [16, 225], 'mosquitoes': [18], 'to': [19, 40, 53, 127, 167, 182, 220], 'transmit': [20], 'pathogens.': [21], 'We': [22], 'tested': [23], 'regulatory': [25], 'region': [26], 'vitellogenin': [29], '(': [30, 67], 'Vg': [31, 57, 135], ')': [32, 69], 'gene': [33], 'Aedes': [35], 'aegypti': [36], 'for': [37, 152], 'its': [38], 'ability': [39], 'express': [41], 'potential': [42], 'antipathogen': [43], 'factors': [44], 'transgenic': [46, 140, 161, 187], 'mosquitoes.': [47, 176], 'Hermes': [48], '-mediated': [49], 'transformation': [50], 'was': [51, 100, 105], 'used': [52], 'integrate': [54], 'a': [55, 113, 120, 156, 210], '2.1-kb': [56], '-promoter': [58], 'fragment': [59], 'driving': [60], 'expression': [62, 130], 'Defensin': [65], 'A': [66], 'DefA': [68], 'coding': [70], 'region,': [71], 'one': [72], 'major': [75], 'insect': [76], 'immune': [77], 'factors.': [78], 'PCR': [79], 'amplification': [80], 'genomic': [82], 'DNA': [83], 'and': [84], 'Southern': [85], 'blot': [86], 'analyses,': [87], 'carried': [88], 'out': [89], 'through': [90, 198], 'ninth': [92], 'generation,': [93], 'showed': [94, 163], 'Vg-DefA': [97, 103], 'transgene': [98, 104], 'insertion': [99], 'stable.': [101], 'The': [102, 116], 'strongly': [106], 'activated': [107, 197], 'fat': [110], 'body': [111], 'by': [112, 205], 'blood': [114, 158, 200], 'meal.': [115], 'mRNA': [117], 'levels': [118, 138], 'reached': [119], 'maximum': [121], 'at': [122], '24-h': [123], 'postblood': [124], 'meal,': [125], 'corresponding': [126], 'peak': [129], 'time': [131], 'endogenous': [134], 'gene.': [136], 'High': [137], 'defensin': [141, 162, 170], 'were': [142], 'accumulated': [143], 'hemolymph': [146], 'bloodfed': [148], 'female': [149], 'mosquitoes,': [150], 'persisting': [151], '20–22': [153], 'days': [154], 'after': [155], 'single': [157], 'feeding.': [159], 'Purified': [160], 'antibacterial': [164], 'activity': [165], 'comparable': [166], 'isolated': [171], 'from': [172], 'bacterially': [173], 'challenged': [174], 'Thus,': [177], 'we': [178], 'have': [179], 'been': [180], 'able': [181], 'engineer': [183], 'genetically': [185], 'stable': [186], 'mosquito': [188], 'with': [189], 'an': [190], 'element': [191], 'systemic': [193], 'immunity,': [194], 'which': [195], 'is': [196], 'meal-triggered': [201], 'cascade': [202], 'rather': [203], 'than': [204], 'infection.': [206], 'This': [207], 'work': [208], 'represents': [209], 'significant': [211], 'step': [212], 'toward': [213], 'genetic': [218], 'approaches': [219], 'vector': [224], 'pathogen': [227], 'transmission.': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153588135', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-13T16:12:28.359649', 'created_date': '2016-06-24'}