Title: Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit.
Abstract: Research Article1 September 1990free access Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit. E. Sawruk E. Sawruk ZMBH, Universität Heidelberg, FRG. Search for more papers by this author P. Schloss P. Schloss ZMBH, Universität Heidelberg, FRG. Search for more papers by this author H. Betz H. Betz ZMBH, Universität Heidelberg, FRG. Search for more papers by this author B. Schmitt B. Schmitt ZMBH, Universität Heidelberg, FRG. Search for more papers by this author E. Sawruk E. Sawruk ZMBH, Universität Heidelberg, FRG. Search for more papers by this author P. Schloss P. Schloss ZMBH, Universität Heidelberg, FRG. Search for more papers by this author H. Betz H. Betz ZMBH, Universität Heidelberg, FRG. Search for more papers by this author B. Schmitt B. Schmitt ZMBH, Universität Heidelberg, FRG. Search for more papers by this author Author Information E. Sawruk1, P. Schloss1, H. Betz1 and B. Schmitt1 1ZMBH, Universität Heidelberg, FRG. The EMBO Journal (1990)9:2671-2677https://doi.org/10.1002/j.1460-2075.1990.tb07452.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Two genes, ard and als, are known to encode subunits of the nicotinic acetylcholine receptor (nAChR) in Drosophila. Here we describe the isolation of cDNA clones encoding a novel member (SAD, or alpha 2) of this receptor protein family. The deduced amino acid sequence displays high homology to the ALS protein and shares structural features with ligand binding nAChR alpha-subunits. Sad transcripts accumulate during major periods of neuronal differentiation and, in embryos, are localized in the central nervous system. Expression of SAD cRNA in Xenopus oocytes generates cation channels that are gated by nicotine. These data indicate heterogeneity of nAChRs in Drosophila. Previous ArticleNext Article Volume 9Issue 91 September 1990In this issue RelatedDetailsLoading ...