Title: Puma, but not noxa is essential for oligodendroglial cell death
Abstract: GliaVolume 61, Issue 10 p. 1712-1723 Original Article Puma, but not noxa is essential for oligodendroglial cell death Karin Hagemeier, Karin Hagemeier Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorAlexander Lürbke, Alexander Lürbke Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorStephanie Hucke, Stephanie Hucke Department of Neurology—Inflammatory Disorders of the Nervous System and Neurooncology, University Hospital Münster, Domagkstr. 13, Münster, GermanySearch for more papers by this authorStefanie Albrecht, Stefanie Albrecht Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorAnna Preisner, Anna Preisner Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorElena Klassen, Elena Klassen Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorElke Hoffmann, Elke Hoffmann Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorQiao-Ling Cui, Qiao-Ling Cui Montreal Neurological Institute, McGill University, Montreal, Québec, CanadaSearch for more papers by this authorJack Antel J, Jack Antel J Montreal Neurological Institute, McGill University, Montreal, Québec, CanadaSearch for more papers by this authorWolfgang Brück, Wolfgang Brück Department of Neuropathology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanySearch for more papers by this authorLuisa Klotz, Luisa Klotz Department of Neurology—Inflammatory Disorders of the Nervous System and Neurooncology, University Hospital Münster, Domagkstr. 13, Münster, GermanySearch for more papers by this authorTanja Kuhlmann, Corresponding Author Tanja Kuhlmann Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanyAddress correspondence to Tanja Kuhlmann; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany. E-mail: [email protected] for more papers by this author Karin Hagemeier, Karin Hagemeier Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorAlexander Lürbke, Alexander Lürbke Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorStephanie Hucke, Stephanie Hucke Department of Neurology—Inflammatory Disorders of the Nervous System and Neurooncology, University Hospital Münster, Domagkstr. 13, Münster, GermanySearch for more papers by this authorStefanie Albrecht, Stefanie Albrecht Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorAnna Preisner, Anna Preisner Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorElena Klassen, Elena Klassen Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorElke Hoffmann, Elke Hoffmann Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanySearch for more papers by this authorQiao-Ling Cui, Qiao-Ling Cui Montreal Neurological Institute, McGill University, Montreal, Québec, CanadaSearch for more papers by this authorJack Antel J, Jack Antel J Montreal Neurological Institute, McGill University, Montreal, Québec, CanadaSearch for more papers by this authorWolfgang Brück, Wolfgang Brück Department of Neuropathology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanySearch for more papers by this authorLuisa Klotz, Luisa Klotz Department of Neurology—Inflammatory Disorders of the Nervous System and Neurooncology, University Hospital Münster, Domagkstr. 13, Münster, GermanySearch for more papers by this authorTanja Kuhlmann, Corresponding Author Tanja Kuhlmann Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, GermanyAddress correspondence to Tanja Kuhlmann; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany. E-mail: [email protected] for more papers by this author First published: 06 August 2013 https://doi.org/10.1002/glia.22552Citations: 14Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The mechanisms involved in oligodendroglial cell death in human demyelinating diseases are only partly understood. Here, we demonstrate that the BH3 only protein Puma, but not Noxa, is essential for oligodendroglial cell death in toxic demyelination induced by the copper chelator cuprizone. Primary oligodendrocytes derived from Noxa- or Puma-deficient mice showed comparable differentiation to wild-type cells, but Puma-deficient oligodendrocytes were less susceptible to spontaneous, staurosporine, or nitric oxide-induced cell death. Furthermore, Puma was expressed in oligodendrocytes in multiple sclerosis (MS) lesions and Puma mRNA levels were upregulated in primary human oligodendrocytes upon cell death induction by staurosporine. Our data demonstrate that Puma is pivotal for oligodendroglial cell death induced by different cell death stimuli and might play a role in oligodendroglial cell death in MS. GLIA 2013;61:1712–1723 Citing Literature Supporting Information Additional Supporting Information may be found in the online version of this article. Filename Description glia22552-sup-0001-suppfig1.tif1.8 MB Supporting Information Figure 1 glia22552-sup-0002-suppfig2.tif1.9 MB Supporting Information Figure 2 glia22552-sup-0003-suppfig3.tif6.2 MB Supporting Information Figure 3 glia22552-sup-0004-suppfig4.tif6.7 MB Supporting Information Figure 4 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume61, Issue10October 2013Pages 1712-1723 RelatedInformation
Publication Year: 2013
Publication Date: 2013-08-06
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 17
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