Title: Plasma Adiponectin Concentrations in Women With Preeclampsia
Abstract: HomeHypertensionVol. 43, No. 4Plasma Adiponectin Concentrations in Women With Preeclampsia Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBPlasma Adiponectin Concentrations in Women With Preeclampsia Koichi Shinohara, Akihiko Wakatsuki, Kazushi Watanabe, Nobuo Ikenoue and Takao Fukaya Koichi ShinoharaKoichi Shinohara Department of Obstetrics and Gynecology Koichi Medical School Koichi, Japan , Akihiko WakatsukiAkihiko Wakatsuki Department of Obstetrics and Gynecology Koichi Medical School Koichi, Japan , Kazushi WatanabeKazushi Watanabe Department of Obstetrics and Gynecology Koichi Medical School Koichi, Japan , Nobuo IkenoueNobuo Ikenoue Department of Obstetrics and Gynecology Koichi Medical School Koichi, Japan and Takao FukayaTakao Fukaya Department of Obstetrics and Gynecology Koichi Medical School Koichi, Japan Originally published2 Feb 2004https://doi.org/10.1161/01.HYP.0000118058.72512.08Hypertension. 2004;43:e17Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: February 2, 2004: Previous Version 1 To the Editor:In their interesting study, Ramsay et al demonstrated that plasma adiponectin concentrations are elevated in women with preeclampsia.1 Adiponectin suppressed tumor necrosis factor (TNF)-α–induced endothelial adhesion molecule expression, macrophage to foam cell transformation, and TNF-α expression in macrophage and adipose tissue. Decreased plasma adiponectin concentrations were observed in subjects with vascular disorders such as obesity, diabetes mellitus, and cardiovascular disease. Thus, adiponectin may have an antiatherogenic effect by reducing vascular damage. Endothelial cell injury and altered endothelial function are important in the pathogenesis of preeclampsia. Ramsay et al speculated that the elevation of adiponectin in preeclamptic women may be secondary to exaggerated nonspecific adipocyte lipolysis or as a physiological response to enhanced fat use. Because adiponectin is an adipocyte-specific plasma protein, plasma adiponectin concentrations are associated with body mass index (BMI). The authors, however, did not indicate the changes in BMI during pregnancy. If the calorie intake was restricted in women with preeclampsia, reduction of body weight may be accompanied by enhanced adiponectin release. Plasma adiponectin concentrations have been reported to correlate negatively with leptin concentrations.2 Although plasma leptin concentrations increased in women with preeclampsia,3 the authors did not measure this parameter. In contrast to their results, our unpublished data showed high leptin and low adiponectin concentrations in preeclamptic women. In addition, C-reactive protein, a systemic marker of inflammation, is elevated in preeclamptic women.4 A recent study demonstrated that adiponectin may inhibit the production of C-reactive protein.5 Based on these findings, it is likely to speculate that decreased adiponectin concentrations may be associated with endothelial dysfunction in women with preeclampsia. Further studies are needed to investigate whether adiponectin is associated with impaired endothelial function in women with preeclampsia.1 Ramsay JE, Jamieson N, Greer IA, Sattar N. Paradoxical Elevation in Adiponectin Concentrations in Women With Preeclampsia. Hypertension. Epub 2003 Sept 29. 2003; 42: 89189–89194.Google Scholar2 Seely EW, Solomon CG. Insulin resistance and its potential role in pregnancy-induced hypertension. J Clin Endocrinol Metab. 2003; 88: 2393–2398.CrossrefMedlineGoogle Scholar3 Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AL, Poston LA. Longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol. 2002; 187: 127–136.CrossrefMedlineGoogle Scholar4 Belo L, Santos-Silva A, Caslake M, Cooney J, Pereira-Leite L, Quintanilha A, Rebelo I. Neutrophil activation and C-reactive protein concentration in preeclampsia. Hypertens Pregnancy. 2003; 22: 129–141.CrossrefMedlineGoogle Scholar5 Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M, Okamoto Y, Ohashi K, Nagaretani H, Kishida K, Nishizawa H, Maeda N, Kobayashi H, Hiraoka H, Matsuzawa Y. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation. 2003; 107: 671–674.LinkGoogle ScholarhypertensionahaHypertensionHypertensionHypertension0194-911X1524-4563Lippincott Williams & WilkinsResponse: Adiponectin Concentrations in PreeclampsiaSattar Naveed, Ramsey Jane, Jamieson Nigel, and Greer Ian A.01042004We thank Shinohara et al for their interest in our article. We recognize that adiponectin has antiinflammatory effects in addition to its insulin-sensitizing actions and that obesity is a major determinant. Indeed, as reported in our article,1 we noted inverse associations of adiponectin concentration with early pregnancy BMI (r=−0.47, P=0.01) and fasting insulin concentrations (r=−0.58, P=0.001) in the control group but not in women with preeclampsia. We were careful to match cases and controls for BMI because pre-pregnancy or early pregnancy BMI, but not weight gain or change during pregnancy, is a recognized risk factor for preeclampsia.2 Thus, we do not feel that baseline adiposity or differential weight change during pregnancy were major confounders in our study.Nevertheless, we were surprised to note "paradoxical" higher adiponectin concentration in women with preeclampsia because we recognize insulin resistance and inflammation are recognized features in such women.3,4 We are therefore in the process of validating our results in other cohorts of women with preeclampsia. In the meantime, we await with interest the full publication by Shinohara et al on this subject. eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Rojas E, Rodríguez-Molina D, Bolli P, Israili Z, Faría J, Fidilio E, Bermúdez V and Velasco M (2014) The Role of Adiponectin in Endothelial Dysfunction and Hypertension, Current Hypertension Reports, 10.1007/s11906-014-0463-7, 16:8, Online publication date: 1-Aug-2014. Liu Y, Zhu L, Pan Y, Sun L, Chen D and Li X (2010) Adiponectin Levels in Circulation and Breast Milk and mRNA Expression in Adipose Tissue of Preeclampsia Women, Hypertension in Pregnancy, 10.3109/10641955.2010.525273, 31:1, (40-49), Online publication date: 1-Feb-2012. Mori T, Shinohara K, Wakatsuki A, Watanabe K and Fujimaki A (2010) Adipocytokines and endothelial function in preeclamptic women, Hypertension Research, 10.1038/hr.2009.222, 33:3, (250-254), Online publication date: 1-Mar-2010. Weiwei T, Haiyan Y, Juan C, Xiaodong W, Weibo C and Rong Z (2009) Expressions of Adiponectin Receptors in Placenta and Their Correlation With Preeclampsia, Reproductive Sciences, 10.1177/1933719109334258, 16:7, (676-684), Online publication date: 1-Jul-2009. Herse F, Youpeng B, Staff A, Yong-Meid J, Dechend R and Rong Z (2009) Circulating and Uteroplacental Adipocytokine Concentrations in Preeclampsia, Reproductive Sciences, 10.1177/1933719109332828, 16:6, (584-590), Online publication date: 1-Jun-2009. Reyna-Villasmil E, Mejia-Montilla J, Reyna-Villasmil N, Santos-Bolívar J, Torres-Cepeda D and Peña-Paredes E (2009) Adiponectina sérica y presión arterial en preeclámpticas y eclámpticas, Clínica e Investigación en Ginecología y Obstetricia, 10.1016/j.gine.2008.09.002, 36:1, (13-18), Online publication date: 1-Jan-2009. Ouyang Y, Chen H and Chen H (2007) Reduced plasma adiponectin and elevated leptin in pre-eclampsia, International Journal of Gynecology & Obstetrics, 10.1016/j.ijgo.2007.04.021, 98:2, (110-114), Online publication date: 1-Aug-2007. Davis G, Mackenzie C, Brown M, Homer C, Holt J, McHugh L and Mangos G (2009) Predicting Transformation from Gestational Hypertension to Preeclampsia in Clinical Practice: A Possible Role for 24 Hour Ambulatory Blood Pressure Monitoring, Hypertension in Pregnancy, 10.1080/10641950601147952, 26:1, (77-87), Online publication date: 1-Jan-2007. Ichida K, Moriyama T, Morita H, Kondo T, Yoshida S, Ohara N and Maruo T (2009) Plasma adiponectin concentrations and placental adiponectin expression in pre-eclamptic women, Gynecological Endocrinology, 10.1080/09513590701297740, 23:4, (238-243), Online publication date: 1-Jan-2007. Saarela T, Hiltunen M, Helisalmi S, Heinonen S and Laakso M (2006) Adiponectin Gene Haplotype Is Associated with Preeclampsia, Genetic Testing, 10.1089/gte.2006.10.35, 10:1, (35-39), Online publication date: 1-Mar-2006. Mazaki-Tovi S, Kanety H and Sivan E (2005) Adiponectin and human pregnancy, Current Diabetes Reports, 10.1007/s11892-005-0023-2, 5:4, (278-281), Online publication date: 1-Jul-2005. April 2004Vol 43, Issue 4 Advertisement Article InformationMetrics https://doi.org/10.1161/01.HYP.0000118058.72512.08PMID: 14757783 Originally publishedFebruary 2, 2004 PDF download Advertisement