Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2102431051', 'doi': 'https://doi.org/10.1161/circresaha.108.179333', 'title': 'Hypoxia-Induced Apelin Expression Regulates Endothelial Cell Proliferation and Regenerative Angiogenesis', 'display_name': 'Hypoxia-Induced Apelin Expression Regulates Endothelial Cell Proliferation and Regenerative Angiogenesis', 'publication_year': 2008, 'publication_date': '2008-07-11', 'ids': {'openalex': 'https://openalex.org/W2102431051', 'doi': 'https://doi.org/10.1161/circresaha.108.179333', 'mag': '2102431051', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18617693'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.108.179333', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.179333', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.179333', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002356299', 'display_name': 'Mélanie Eyries', 'orcid': 'https://orcid.org/0000-0003-1911-6698'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mélanie Eyries', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034988767', 'display_name': 'Géraldine Siegfried', 'orcid': 'https://orcid.org/0000-0002-6346-5206'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Géraldine Siegfried', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063615941', 'display_name': 'Mariana Ciumas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mariana Ciumas', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075726758', 'display_name': 'Kévin Montagne', 'orcid': 'https://orcid.org/0000-0002-9551-0593'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Kevin Montagne', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025610388', 'display_name': 'Monique Agrapart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Monique Agrapart', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051185238', 'display_name': 'Franck Lebrin', 'orcid': 'https://orcid.org/0000-0002-1650-6757'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Franck Lebrin', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028678474', 'display_name': 'Florent Soubrier', 'orcid': 'https://orcid.org/0000-0003-2571-7932'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Florent Soubrier', 'raw_affiliation_strings': ['From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).'], 'affiliations': [{'raw_affiliation_string': 'From INSERM UMRS 525, Université Pierre et Marie Curie, Paris (M.E., M.C., K.M., M.A., F.L., F.S.); and INSERM U770, Université Paris-sud, Le Kremlin-Bicêtre, France (G.S.).', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.766, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 246, 'citation_normalized_percentile': {'value': 0.999903, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '103', 'issue': '4', 'first_page': '432', 'last_page': '440'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13505', 'display_name': 'Apelin Signaling and Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13505', 'display_name': 'Apelin Signaling and Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14486', 'display_name': 'Role of Urotensin II in Cardiovascular Physiology and Disease', 'score': 0.9778, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13430', 'display_name': 'Lipid Metabolism and Cardiovascular Disease', 'score': 0.9711, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia (environmental)', 'score': 0.75713265}, {'id': 'https://openalex.org/keywords/apelin', 'display_name': 'Apelin', 'score': 0.508339}, {'id': 'https://openalex.org/keywords/regenerative-medicine', 'display_name': 'Regenerative medicine', 'score': 0.49348748}], 'concepts': [{'id': 'https://openalex.org/C2779546753', 'wikidata': 'https://www.wikidata.org/wiki/Q2386988', 'display_name': 'Apelin', 'level': 3, 'score': 0.8712324}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8578595}, {'id': 'https://openalex.org/C7836513', 'wikidata': 'https://www.wikidata.org/wiki/Q1641506', 'display_name': 'Hypoxia (environmental)', 'level': 3, 'score': 0.75713265}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.62964606}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.53507614}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.50694036}, {'id': 'https://openalex.org/C10854531', 'wikidata': 'https://www.wikidata.org/wiki/Q1061415', 'display_name': 'Regenerative medicine', 'level': 3, 'score': 0.49348748}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41543144}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3045898}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.24540117}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.16655236}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08374503}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054392', 'descriptor_name': 'Adipokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073861', 'descriptor_name': 'Apelin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018925', 'descriptor_name': 'Chemokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018925', 'descriptor_name': 'Chemokines', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018925', 'descriptor_name': 'Chemokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.108.179333', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.179333', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18617693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.108.179333', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.179333', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1483762900', 'https://openalex.org/W1497027525', 'https://openalex.org/W1990991922', 'https://openalex.org/W2012471255', 'https://openalex.org/W2019759067', 'https://openalex.org/W2030445959', 'https://openalex.org/W2048326563', 'https://openalex.org/W2050869563', 'https://openalex.org/W2052769848', 'https://openalex.org/W2057556321', 'https://openalex.org/W2058135511', 'https://openalex.org/W2063507448', 'https://openalex.org/W2064295299', 'https://openalex.org/W2066199622', 'https://openalex.org/W2067874044', 'https://openalex.org/W2081184877', 'https://openalex.org/W2082034988', 'https://openalex.org/W2087867260', 'https://openalex.org/W2091760375', 'https://openalex.org/W2095336765', 'https://openalex.org/W2098382903', 'https://openalex.org/W2098905900', 'https://openalex.org/W2107422953', 'https://openalex.org/W2115957483', 'https://openalex.org/W2118803031', 'https://openalex.org/W2127087522', 'https://openalex.org/W2127776747', 'https://openalex.org/W2129224037', 'https://openalex.org/W2131422219', 'https://openalex.org/W2139032664', 'https://openalex.org/W2145826667', 'https://openalex.org/W2145865644', 'https://openalex.org/W2147581368', 'https://openalex.org/W4244190676'], 'related_works': ['https://openalex.org/W67696469', 'https://openalex.org/W3109172733', 'https://openalex.org/W3035527255', 'https://openalex.org/W3021516290', 'https://openalex.org/W2970846649', 'https://openalex.org/W2548162453', 'https://openalex.org/W2401854918', 'https://openalex.org/W2364551211', 'https://openalex.org/W2083248611', 'https://openalex.org/W2044092797'], 'abstract_inverted_index': {'Apelin': [0], 'has': [1, 34], 'been': [2, 35], 'identified': [3], 'as': [4, 27, 82, 84], 'the': [5, 9, 42, 50, 53, 57, 111, 115, 128, 134, 143, 186], 'endogenous': [6, 129], 'ligand': [7], 'of': [8, 21, 30, 56, 101, 114, 133, 139, 146, 190, 211], 'human': [10, 116], 'orphan': [11], 'G': [12], 'protein–coupled': [13], 'receptor': [14, 171], 'APJ.': [15], 'This': [16], 'peptide': [17], 'exerts': [18], 'a': [19, 147, 201], 'variety': [20], 'cardiovascular': [22], 'effects': [23], 'and': [24, 49, 77, 181, 208], 'particularly': [25], 'acts': [26], 'an': [28, 104], 'activator': [29], 'angiogenesis.': [31], 'Importantly,': [32], 'hypoxia': [33, 73], 'reported': [36], 'to': [37, 90, 127, 214], 'regulate': [38], 'apelin': [39, 47, 68, 102, 117, 135, 163, 168, 196], 'expression': [40, 48, 69, 197], 'but': [41], 'molecular': [43], 'mechanism': [44, 203], 'underlying': [45], 'hypoxia-induced': [46, 162, 175, 182, 195], 'relationship': [51], 'with': [52], 'physiological': [54, 207], 'response': [55, 210], 'apelin/APJ': [58], 'system': [59], 'are': [60], 'still': [61], 'not': [62], 'established.': [63], 'Here,': [64], 'we': [65], 'demonstrate': [66], 'that': [67, 97, 123], 'is': [70], 'induced': [71], 'by': [72], 'in': [74, 85, 179, 185, 205], 'cultured': [75], 'endothelial': [76, 176], 'vascular': [78, 212], 'smooth': [79], 'muscle': [80], 'cells': [81, 213], 'well': [83], 'lung': [86], 'from': [87], 'mice': [88], 'exposed': [89], 'acute': [91], 'hypoxia.': [92], 'Transient': [93], 'transfection': [94], 'experiments': [95], 'show': [96], 'hypoxia-inducible': [98, 124, 140, 158], 'transcriptional': [99, 144], 'activation': [100], 'requires': [103], 'intact': [105], 'hypoxia-responsive': [106, 130, 152], 'element': [107, 131], '(+813/+826)': [108], 'located': [109], 'within': [110], 'first': [112], 'intron': [113], 'gene.': [118, 136], 'Chromatin': [119], 'immunoprecipitation': [120], 'assay': [121], 'reveals': [122], 'factor-1α': [125, 141, 159], 'binds': [126], 'site': [132], 'Moreover,': [137], 'overexpression': [138], 'increases': [142], 'activity': [145], 'reporter': [148], 'construct': [149], 'containing': [150], 'this': [151], 'element,': [153], 'whereas': [154], 'small': [155], 'interfering': [156], 'RNA–mediated': [157], 'knockdown': [160, 172], 'abolishes': [161], 'expression.': [164], 'Finally,': [165], 'microinterfering': [166], 'RNA-mediated': [167], 'or': [169], 'APJ': [170], 'inhibits': [173], 'both': [174], 'cell': [177], 'proliferation': [178], 'vitro': [180], 'vessel': [183], 'regeneration': [184, 189], 'caudal': [187], 'fin': [188], 'Fli-1': [191], 'transgenic': [192], 'zebrafish.': [193], 'The': [194], 'may,': [198], 'thus,': [199], 'provide': [200], 'new': [202], 'involved': [204], 'adaptive': [206], 'pathophysiological': [209], 'low': [215], 'oxygen': [216], 'level.': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102431051', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-26T23:28:57.113514', 'created_date': '2016-06-24'}