Publication Information

{'id': 'https://openalex.org/W2091256633', 'doi': 'https://doi.org/10.1371/journal.pone.0119441', 'title': 'Ablation of Tumor Necrosis Factor Is Associated with Decreased Inflammation and Alterations of the Microbiota in a Mouse Model of Inflammatory Bowel Disease', 'display_name': 'Ablation of Tumor Necrosis Factor Is Associated with Decreased Inflammation and Alterations of the Microbiota in a Mouse Model of Inflammatory Bowel Disease', 'publication_year': 2015, 'publication_date': '2015-03-16', 'ids': {'openalex': 'https://openalex.org/W2091256633', 'doi': 'https://doi.org/10.1371/journal.pone.0119441', 'mag': '2091256633', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25860670', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4393316'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0119441', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119441&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119441&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068129740', 'display_name': 'Yava Jones‐Hall', 'orcid': 'https://orcid.org/0000-0003-4030-9830'}, 'institutions': [{'id': 'https://openalex.org/I219193219', 'display_name': 'Purdue University West Lafayette', 'ror': 'https://ror.org/02dqehb95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I219193219']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yava L. Jones-Hall', 'raw_affiliation_strings': ['Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I219193219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015780224', 'display_name': 'Ariangela J. Kozik', 'orcid': 'https://orcid.org/0000-0003-2322-4085'}, 'institutions': [{'id': 'https://openalex.org/I219193219', 'display_name': 'Purdue University West Lafayette', 'ror': 'https://ror.org/02dqehb95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I219193219']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ariangela Kozik', 'raw_affiliation_strings': ['Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America', 'Purdue University Interdisciplinary Life Science Program (PULSe), West Lafayette, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I219193219']}, {'raw_affiliation_string': 'Purdue University Interdisciplinary Life Science Program (PULSe), West Lafayette, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I219193219']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080809237', 'display_name': 'Cindy H. Nakatsu', 'orcid': 'https://orcid.org/0000-0003-0663-180X'}, 'institutions': [{'id': 'https://openalex.org/I219193219', 'display_name': 'Purdue University West Lafayette', 'ror': 'https://ror.org/02dqehb95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I219193219']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cindy Nakatsu', 'raw_affiliation_strings': ['Department of Agronomy, Purdue University, West Lafayette, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Agronomy, Purdue University, West Lafayette, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I219193219']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5068129740'], 'corresponding_institution_ids': ['https://openalex.org/I219193219'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 4.537, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '10', 'issue': '3', 'first_page': 'e0119441', 'last_page': 'e0119441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10134', 'display_name': 'Genetics and Treatment of Inflammatory Bowel Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10134', 'display_name': 'Genetics and Treatment of Inflammatory Bowel Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13569', 'display_name': 'Epidemiology and Treatment of Microscopic Colitis', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10276', 'display_name': 'Helicobacter pylori Infection and Gastric Cancer', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/inflammation', 'display_name': 'Inflammation', 'score': 0.512383}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.419174}], 'concepts': [{'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.8741703}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.7965797}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.70235264}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6089009}, {'id': 'https://openalex.org/C2775862500', 'wikidata': 'https://www.wikidata.org/wiki/Q2453464', 'display_name': 'Colitis', 'level': 2, 'score': 0.59374225}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.53506595}, {'id': 'https://openalex.org/C143121216', 'wikidata': 'https://www.wikidata.org/wiki/Q1330402', 'display_name': 'Microbiome', 'level': 2, 'score': 0.5292874}, {'id': 'https://openalex.org/C2780479503', 'wikidata': 'https://www.wikidata.org/wiki/Q1477', 'display_name': 'Ulcerative colitis', 'level': 3, 'score': 0.5282582}, {'id': 'https://openalex.org/C539455810', 'wikidata': 'https://www.wikidata.org/wiki/Q739734', 'display_name': 'Gut flora', 'level': 2, 'score': 0.5251557}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5045079}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.419174}, {'id': 'https://openalex.org/C2779280984', 'wikidata': 'https://www.wikidata.org/wiki/Q1472', 'display_name': "Crohn's disease", 'level': 3, 'score': 0.41529387}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3782994}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.35917056}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.21990746}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18089747}], 'mesh': [{'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': True}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005243', 'descriptor_name': 'Feces', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D005243', 'descriptor_name': 'Feces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014302', 'descriptor_name': 'Trinitrobenzenesulfonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0119441', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119441&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/958c58804d544f17a1a61ef92f0ec8ec', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4361568', 'pdf_url': 'https://europepmc.org/articles/pmc4361568?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25775453', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0119441', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119441&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W156088739', 'https://openalex.org/W1876104850', 'https://openalex.org/W1964815186', 'https://openalex.org/W1965383388', 'https://openalex.org/W1988105075', 'https://openalex.org/W1989838453', 'https://openalex.org/W1996632586', 'https://openalex.org/W2004177186', 'https://openalex.org/W2008647124', 'https://openalex.org/W2009170813', 'https://openalex.org/W2016471908', 'https://openalex.org/W2016537283', 'https://openalex.org/W2017447237', 'https://openalex.org/W2028547258', 'https://openalex.org/W2030364983', 'https://openalex.org/W2033239478', 'https://openalex.org/W2035187012', 'https://openalex.org/W2038838030', 'https://openalex.org/W2047208232', 'https://openalex.org/W2047398409', 'https://openalex.org/W2058250733', 'https://openalex.org/W2062041228', 'https://openalex.org/W2063053479', 'https://openalex.org/W2063731747', 'https://openalex.org/W2064385743', 'https://openalex.org/W2066203385', 'https://openalex.org/W2071833233', 'https://openalex.org/W2072523194', 'https://openalex.org/W2072970694', 'https://openalex.org/W20761558', 'https://openalex.org/W2078621117', 'https://openalex.org/W2081683081', 'https://openalex.org/W2082471133', 'https://openalex.org/W2088170171', 'https://openalex.org/W2099376515', 'https://openalex.org/W2102859444', 'https://openalex.org/W2105274559', 'https://openalex.org/W2118327902', 'https://openalex.org/W2121079175', 'https://openalex.org/W2122292170', 'https://openalex.org/W2123655574', 'https://openalex.org/W2123914286', 'https://openalex.org/W2127693350', 'https://openalex.org/W2131458843', 'https://openalex.org/W2132548846', 'https://openalex.org/W2135233223', 'https://openalex.org/W2137529401', 'https://openalex.org/W2143326552', 'https://openalex.org/W2143777796', 'https://openalex.org/W2144152742', 'https://openalex.org/W2145416697', 'https://openalex.org/W2146503791', 'https://openalex.org/W2152751713', 'https://openalex.org/W2154026962', 'https://openalex.org/W2154276474', 'https://openalex.org/W2158795865', 'https://openalex.org/W2161163382', 'https://openalex.org/W2164232580', 'https://openalex.org/W2165122599', 'https://openalex.org/W2167637859', 'https://openalex.org/W2167941657', 'https://openalex.org/W2168834895', 'https://openalex.org/W2169584514', 'https://openalex.org/W2169910756', 'https://openalex.org/W2412378934', 'https://openalex.org/W4241582805', 'https://openalex.org/W4242702784', 'https://openalex.org/W4249181320', 'https://openalex.org/W4292198229'], 'related_works': ['https://openalex.org/W4385147599', 'https://openalex.org/W4224234790', 'https://openalex.org/W3151390891', 'https://openalex.org/W2964993277', 'https://openalex.org/W2944370844', 'https://openalex.org/W2393318770', 'https://openalex.org/W2391150797', 'https://openalex.org/W2381376498', 'https://openalex.org/W2378399001', 'https://openalex.org/W2369056725'], 'abstract_inverted_index': {'Inflammatory': [0], 'bowel': [1], 'disease': [2], '(IBD)': [3], 'is': [4], 'associated': [5, 51], 'with': [6, 17, 52], 'prolonged,': [7], 'excess': [8], 'secretions': [9], 'of': [10, 22, 55, 62, 90], 'Tumor': [11], 'Necrosis': [12], 'Factor': [13], '(TNF).': [14], 'Many': [15], 'patients': [16, 33], 'IBD': [18, 23], 'have': [19], 'successful': [20], 'management': [21], 'symptoms': [24], 'by': [25], 'blocking': [26], 'TNF': [27, 56, 91, 145], 'secretion': [28], 'or': [29, 44, 98], 'signaling.': [30], 'However,': [31], 'some': [32, 68], 'are': [34, 50], 'non-responsive': [35], 'to': [36, 42, 86, 148], 'this': [37, 63], 'therapy,': [38, 43], 'eventually': [39], 'become': [40], 'refractory': [41], 'Alterations': [45], 'in': [46, 67, 80, 92, 120, 130, 154, 157], 'the': [47, 53, 88, 101, 149], 'microbiota': [48], 'that': [49, 133, 144, 155], 'lack': [54], 'could': [57], 'be': [58], 'a': [59], 'contributing': [60], 'cause': [61], 'therapeutic': [64], 'insufficiency': [65], 'seen': [66], 'patients.': [69], 'Here': [70], 'we': [71], 'use': [72], 'wildtype': [73], '(WT)': [74], 'and': [75, 94, 122, 151], 'mice': [76], 'lacking': [77], 'Tnf': [78, 118, 137], '(Tnf-/-)': [79], 'an': [81], 'acute': [82], 'TNBS': [83], 'colitis': [84, 93], 'model': [85], 'investigate': [87], 'role': [89], 'how': [95], 'its': [96], 'presence': [97], 'absence': [99], 'affects': [100], 'colonic': [102], 'microbiota.': [103], 'As': [104], 'expected,': [105], 'Tnf-/-': [106], 'had': [107], 'less': [108], 'severe': [109], 'inflammation': [110, 150], 'than': [111], 'WT': [112], 'mice.': [113], 'Microbiome': [114], 'analysis': [115], 'revealed': [116], 'significant': [117], 'dependent-differences': [119], 'alpha': [121], 'beta': [123], 'diversity.': [124], 'There': [125], 'were': [126, 134], 'also': [127, 135], 'notable': [128], 'differences': [129], 'many': [131], 'species': [132], 'primarily': [136], 'dependent.': [138], 'Taken': [139], 'together,': [140], 'our': [141], 'data': [142], 'indicates': [143], 'contributes': [146], 'significantly': [147], 'microbiotal': [152], 'alterations': [153], 'occur': [156], 'IBD.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091256633', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-26T02:10:35.856613', 'created_date': '2016-06-24'}