Publication Information

{'id': 'https://openalex.org/W2088572699', 'doi': 'https://doi.org/10.1016/j.jbiotec.2011.08.021', 'title': 'Inhibition effect of isopropanol on acetyl-CoA synthetase expression level of acetoclastic methanogen, Methanosaeta concilii', 'display_name': 'Inhibition effect of isopropanol on acetyl-CoA synthetase expression level of acetoclastic methanogen, Methanosaeta concilii', 'publication_year': 2011, 'publication_date': '2011-08-23', 'ids': {'openalex': 'https://openalex.org/W2088572699', 'doi': 'https://doi.org/10.1016/j.jbiotec.2011.08.021', 'mag': '2088572699', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21884734'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jbiotec.2011.08.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S182099265', 'display_name': 'Journal of Biotechnology', 'issn_l': '0168-1656', 'issn': ['0168-1656', '1873-4863'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056196601', 'display_name': 'Bahar İnce', 'orcid': 'https://orcid.org/0000-0001-6205-2074'}, 'institutions': [{'id': 'https://openalex.org/I4405392', 'display_name': 'Boğaziçi University', 'ror': 'https://ror.org/03z9tma90', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I4405392']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Bahar Ince', 'raw_affiliation_strings': ['Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.'], 'affiliations': [{'raw_affiliation_string': 'Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.', 'institution_ids': ['https://openalex.org/I4405392']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011209944', 'display_name': 'Gozde Aydin', 'orcid': 'https://orcid.org/0000-0001-5535-6053'}, 'institutions': [{'id': 'https://openalex.org/I4405392', 'display_name': 'Boğaziçi University', 'ror': 'https://ror.org/03z9tma90', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I4405392']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Gozde Koksel', 'raw_affiliation_strings': ['Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.'], 'affiliations': [{'raw_affiliation_string': 'Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.', 'institution_ids': ['https://openalex.org/I4405392']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049480220', 'display_name': 'Zeynep Çetecioğlu', 'orcid': 'https://orcid.org/0000-0002-8170-379X'}, 'institutions': [{'id': 'https://openalex.org/I48912391', 'display_name': 'Istanbul Technical University', 'ror': 'https://ror.org/059636586', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I48912391']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Zeynep Cetecioglu', 'raw_affiliation_strings': ['Istanbul Technical University, Department of Environmental Eng., Maslak, 34469 Istanbul, Turkey'], 'affiliations': [{'raw_affiliation_string': 'Istanbul Technical University, Department of Environmental Eng., Maslak, 34469 Istanbul, Turkey', 'institution_ids': ['https://openalex.org/I48912391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066218191', 'display_name': 'Nilgün Ayman Öz', 'orcid': 'https://orcid.org/0000-0002-6309-0547'}, 'institutions': [{'id': 'https://openalex.org/I115953327', 'display_name': 'Çanakkale Onsekiz Mart Üniversitesi', 'ror': 'https://ror.org/05rsv8p09', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I115953327']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Nilgun Ayman Oz', 'raw_affiliation_strings': ['Canakkale Onsekiz Mart University, Faculty of Engineering and Architecture, Department of Environmental Engineering, Canakkale, Turkey;'], 'affiliations': [{'raw_affiliation_string': 'Canakkale Onsekiz Mart University, Faculty of Engineering and Architecture, Department of Environmental Engineering, Canakkale, Turkey;', 'institution_ids': ['https://openalex.org/I115953327']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004241422', 'display_name': 'Halil Coban', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4405392', 'display_name': 'Boğaziçi University', 'ror': 'https://ror.org/03z9tma90', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I4405392']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Halil Coban', 'raw_affiliation_strings': ['Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.'], 'affiliations': [{'raw_affiliation_string': 'Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul, Turkey.', 'institution_ids': ['https://openalex.org/I4405392']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048164286', 'display_name': 'Orhan İnce', 'orcid': 'https://orcid.org/0000-0001-5028-8872'}, 'institutions': [{'id': 'https://openalex.org/I48912391', 'display_name': 'Istanbul Technical University', 'ror': 'https://ror.org/059636586', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I48912391']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Orhan Ince', 'raw_affiliation_strings': ['Istanbul Technical University, Department of Environmental Eng., Maslak, 34469 Istanbul, Turkey'], 'affiliations': [{'raw_affiliation_string': 'Istanbul Technical University, Department of Environmental Eng., Maslak, 34469 Istanbul, Turkey', 'institution_ids': ['https://openalex.org/I48912391']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3680, 'currency': 'USD', 'value_usd': 3680, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.578, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.929765, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '156', 'issue': '2', 'first_page': '95', 'last_page': '99'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10284', 'display_name': 'Anaerobic Digestion and Biogas Production', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2215', 'display_name': 'Building and Construction'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10284', 'display_name': 'Anaerobic Digestion and Biogas Production', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2215', 'display_name': 'Building and Construction'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10324', 'display_name': 'Microbial Bioremediation of Organic Pollutants', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10564', 'display_name': 'Microbial Nitrogen Cycling in Wastewater Treatment Systems', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/methanosaeta', 'display_name': 'Methanosaeta', 'score': 0.98038626}, {'id': 'https://openalex.org/keywords/methanogen', 'display_name': 'Methanogen', 'score': 0.91348016}, {'id': 'https://openalex.org/keywords/hydrogen-production', 'display_name': 'Hydrogen Production', 'score': 0.437152}], 'concepts': [{'id': 'https://openalex.org/C2777007170', 'wikidata': 'https://www.wikidata.org/wiki/Q1952733', 'display_name': 'Methanosaeta', 'level': 4, 'score': 0.98038626}, {'id': 'https://openalex.org/C2777438225', 'wikidata': 'https://www.wikidata.org/wiki/Q1169785', 'display_name': 'Methanogen', 'level': 3, 'score': 0.91348016}, {'id': 'https://openalex.org/C2778589620', 'wikidata': 'https://www.wikidata.org/wiki/Q22275999', 'display_name': 'Methanogenesis', 'level': 3, 'score': 0.84871525}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5380333}, {'id': 'https://openalex.org/C2778563749', 'wikidata': 'https://www.wikidata.org/wiki/Q1942715', 'display_name': 'Methanosarcina', 'level': 4, 'score': 0.5272077}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.4326146}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3696968}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3449859}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.32732722}, {'id': 'https://openalex.org/C516920438', 'wikidata': 'https://www.wikidata.org/wiki/Q37129', 'display_name': 'Methane', 'level': 2, 'score': 0.28023905}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.068933904}], 'mesh': [{'descriptor_ui': 'D019840', 'descriptor_name': '2-Propanol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D019640', 'descriptor_name': 'Methanosarcinales', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D019840', 'descriptor_name': '2-Propanol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000085', 'descriptor_name': 'Acetates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000085', 'descriptor_name': 'Acetates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000105', 'descriptor_name': 'Acetyl Coenzyme A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000105', 'descriptor_name': 'Acetyl Coenzyme A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D019149', 'descriptor_name': 'Bioreactors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017404', 'descriptor_name': 'In Situ Hybridization, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008697', 'descriptor_name': 'Methane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008697', 'descriptor_name': 'Methane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019640', 'descriptor_name': 'Methanosarcinales', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012997', 'descriptor_name': 'Solvents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012997', 'descriptor_name': 'Solvents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jbiotec.2011.08.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S182099265', 'display_name': 'Journal of Biotechnology', 'issn_l': '0168-1656', 'issn': ['0168-1656', '1873-4863'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21884734', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1493599431', 'https://openalex.org/W1494583674', 'https://openalex.org/W1503353321', 'https://openalex.org/W1543436264', 'https://openalex.org/W1561580658', 'https://openalex.org/W1701869895', 'https://openalex.org/W1819951161', 'https://openalex.org/W1856219842', 'https://openalex.org/W1976606391', 'https://openalex.org/W1982088266', 'https://openalex.org/W1993817750', 'https://openalex.org/W2002310397', 'https://openalex.org/W2027127704', 'https://openalex.org/W2035775871', 'https://openalex.org/W2069858894', 'https://openalex.org/W2084725505', 'https://openalex.org/W2089848749', 'https://openalex.org/W2103051521', 'https://openalex.org/W2117058964', 'https://openalex.org/W2123013990', 'https://openalex.org/W2135898016', 'https://openalex.org/W2162512008', 'https://openalex.org/W2173924792', 'https://openalex.org/W2330259888', 'https://openalex.org/W2470186410', 'https://openalex.org/W26720159', 'https://openalex.org/W3101280595', 'https://openalex.org/W346827628', 'https://openalex.org/W4249456122'], 'related_works': ['https://openalex.org/W4232710487', 'https://openalex.org/W3176439267', 'https://openalex.org/W2905146560', 'https://openalex.org/W2554142222', 'https://openalex.org/W240577217', 'https://openalex.org/W2135040820', 'https://openalex.org/W2083897791', 'https://openalex.org/W2069858894', 'https://openalex.org/W2009049643', 'https://openalex.org/W1484221008'], 'abstract_inverted_index': {'Isopropanol': [0], 'is': [1], 'a': [2, 64], 'widely': [3], 'found': [4], 'solvent': [5], 'in': [6, 29, 38, 67, 85, 101, 116, 123, 133, 153], 'industrial': [7], 'wastewaters,': [8], 'which': [9], 'have': [10], 'commonly': [11], 'been': [12], 'treated': [13], 'using': [14, 83], 'anaerobic': [15, 30], 'systems.': [16], 'In': [17], 'this': [18], 'study,': [19], 'inhibitory': [20, 182], 'effect': [21, 56, 183], 'of': [22, 57, 63, 73, 91, 139, 160, 164, 196], 'isopropanol': [23, 58, 114, 137, 179], 'on': [24, 59, 184], 'the': [25, 60, 102, 158, 188], 'key': [26, 65], 'microbial': [27], 'group': [28], 'bioreactors,': [31], 'acetoclastic': [32, 68, 185], 'methanogens,': [33], 'was': [34, 52, 94], 'investigated.': [35], 'Anaerobic': [36], 'sludges': [37], 'serum': [39], 'bottles': [40], 'were': [41, 80, 168], 'repeatedly': [42], 'fed': [43], 'with': [44, 105], 'acetate': [45], 'and': [46, 48, 120, 126, 130, 146, 156, 187, 199], 'isopropanol;': [47], 'quantitative': [49], 'real-time': [50], 'PCR': [51], 'used': [53], 'for': [54, 136], 'determining': [55], 'expression': [61], 'level': [62, 125, 195], 'enzyme': [66], 'methane': [69, 109, 134], 'production,': [70], 'acetyl-CoA': [71, 92, 197], 'synthetase': [72, 93], 'Methanosaeta': [74, 77, 166], 'concilii.': [75], 'Active': [76], 'spp.': [78], 'cells': [79, 167], 'also': [81], 'quantified': [82], 'Fluorescent': [84], 'situ': [86], 'hybridization': [87], '(FISH).': [88], 'Transcript': [89], 'abundance': [90], '1.23': [95], '±': [96], '0.62': [97], '×': [98], '106': [99], 'mRNAs/mL': [100], 'uninhibited': [103], 'reactors': [104], '222': [106], 'mL': [107], 'cumulative': [108], 'production.': [110], 'First': [111], 'exposure': [112], 'to': [113, 172], 'resulted': [115, 152], '71.2%,': [117], '84.7%,': [118], '89.2%': [119], '94.6%': [121], 'decrease': [122], 'mRNA': [124], '35.0%,': [127], '65.0%,': [128], '91.5%': [129], '100.0%': [131], 'reduction': [132], 'production': [135], 'concentrations': [138], '0.1': [140], 'M,': [141, 143, 148], '0.5': [142], '1.0': [144], 'M': [145], '2.0': [147], 'respectively.': [149], 'Repeated': [150], 'exposures': [151], 'higher': [154], 'inhibitions;': [155], 'at': [157], 'end': [159], 'test,': [161], 'fluorescent': [162], 'intensities': [163], 'active': [165], 'significantly': [169], 'decreased': [170], 'due': [171], 'isopropanol.': [173], 'The': [174], 'overall': [175], 'results': [176], 'indicated': [177], 'that': [178], 'has': [180], 'an': [181], 'methanogenesis;': [186], 'inhibition': [189], 'can': [190], 'be': [191], 'detected': [192], 'by': [193], 'monitoring': [194], 'transcripts': [198], 'rRNA': [200], 'level.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2088572699', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-09-17T16:07:38.789190', 'created_date': '2016-06-24'}