Abstract: E-cadherin-based adherens junctions are required for proper adhesion and orientation of epithelial cells within a sheet, as well as playing a role in asymmetric cell division. Although a lot is known – about how E-cadherin-based junctions link to the cytoskeleton, much less is known – about how their localization in the cell is controlled. Recent work by Knox and Brown in Drosophila highlights the importance of the small GTPase Rap1 in maintaining the even distribution of adherens junctions around the cell [ 1. Knox A. Brown N. Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science. 2002; 295: 1285-1288 Crossref PubMed Scopus (201) Google Scholar ].
Publication Year: 2002
Publication Date: 2002-06-01
Language: en
Type: article
Indexed In: ['crossref']
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