Title: Novel polymer system for molecular imprinting polymer against amino acid derivatives
Abstract: Abstract Molecular imprinting polymers (MIPs) against N‐Cbz‐L‐ Tyr were prepared utilizing different polymer systems and evaluated in HPLC mode. It was found that MIP utilizing cocktail functional monomers, acrylamide + 2‐vinylpyridine showed better molecular recognition and better separation ability for the template molecule than those utilizing other functional monomers. MIP utilizing trimethylolpropane trimethacrylate as cross‐linker showed higher load capacity and separation factor than those utilizing ethylene glycol dimethacrylate as cross‐linker. Increasing the concentration of competing solvent, acetic acid weakened me ionic interaction and hydrogen bonding between the analyte and the functional monomers, 2‐vinylpyridine and acrylamide, when me template enantiomer was separated by HPLC. Therefore increasing of the concentration of acetic acid leads to decreasing of capacity factor, separation factor and resolution.
Publication Year: 2000
Publication Date: 2000-07-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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