Publication Information

{'id': 'https://openalex.org/W2082992930', 'doi': 'https://doi.org/10.1128/aac.00394-06', 'title': 'Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite <i>Plasmodium falciparum</i>', 'display_name': 'Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite <i>Plasmodium falciparum</i>', 'publication_year': 2006, 'publication_date': '2006-08-28', 'ids': {'openalex': 'https://openalex.org/W2082992930', 'doi': 'https://doi.org/10.1128/aac.00394-06', 'mag': '2082992930', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16940111', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1563505'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00394-06', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/aac.00394-06', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091387119', 'display_name': 'Erica L. Dahl', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Erica L. Dahl', 'raw_affiliation_strings': ['Department of Medicine, Box 0811'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Box 0811', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030057098', 'display_name': 'Jennifer Leigh Shock', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer L. Shock', 'raw_affiliation_strings': ['Department of Biochemistry and Biophysics, Box 2240, University of California—San Francisco, San Francisco, California 94143'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biophysics, Box 2240, University of California—San Francisco, San Francisco, California 94143', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055521023', 'display_name': 'Bhaskar R. Shenai', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bhaskar R. Shenai', 'raw_affiliation_strings': ['Department of Medicine, Box 0811'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Box 0811', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111566126', 'display_name': 'Jiří Gut', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jiri Gut', 'raw_affiliation_strings': ['Department of Medicine, Box 0811'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Box 0811', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039824565', 'display_name': 'Joseph L. DeRisi', 'orcid': 'https://orcid.org/0000-0002-4611-9205'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph L. DeRisi', 'raw_affiliation_strings': ['Department of Biochemistry and Biophysics, Box 2240, University of California—San Francisco, San Francisco, California 94143'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biophysics, Box 2240, University of California—San Francisco, San Francisco, California 94143', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077631479', 'display_name': 'Philip J. Rosenthal', 'orcid': 'https://orcid.org/0000-0002-7953-7622'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Philip J. Rosenthal', 'raw_affiliation_strings': ['Department of Medicine, Box 0811'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Box 0811', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.794, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 258, 'citation_normalized_percentile': {'value': 0.99996, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '50', 'issue': '9', 'first_page': '3124', 'last_page': '3131'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apicoplast', 'display_name': 'Apicoplast', 'score': 0.99681926}, {'id': 'https://openalex.org/keywords/organelle', 'display_name': 'Organelle', 'score': 0.55343693}], 'concepts': [{'id': 'https://openalex.org/C2775855988', 'wikidata': 'https://www.wikidata.org/wiki/Q1825478', 'display_name': 'Apicoplast', 'level': 5, 'score': 0.99681926}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7974689}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.75371224}, {'id': 'https://openalex.org/C2777179404', 'wikidata': 'https://www.wikidata.org/wiki/Q422442', 'display_name': 'Doxycycline', 'level': 3, 'score': 0.69389546}, {'id': 'https://openalex.org/C168240541', 'wikidata': 'https://www.wikidata.org/wiki/Q45948', 'display_name': 'Organelle', 'level': 2, 'score': 0.55343693}, {'id': 'https://openalex.org/C93829228', 'wikidata': 'https://www.wikidata.org/wiki/Q165963', 'display_name': 'Plastid', 'level': 4, 'score': 0.50779897}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.5077337}, {'id': 'https://openalex.org/C2781023229', 'wikidata': 'https://www.wikidata.org/wiki/Q193030', 'display_name': 'Apicomplexa', 'level': 4, 'score': 0.48833796}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.4624159}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4080443}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39886665}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.38856456}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.28327096}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.100951254}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.085902005}, {'id': 'https://openalex.org/C69305403', 'wikidata': 'https://www.wikidata.org/wiki/Q47263', 'display_name': 'Chloroplast', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013754', 'descriptor_name': 'Tetracyclines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016054', 'descriptor_name': 'DNA, Protozoan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016054', 'descriptor_name': 'DNA, Protozoan', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016054', 'descriptor_name': 'DNA, Protozoan', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013754', 'descriptor_name': 'Tetracyclines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00394-06', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1563505', 'pdf_url': 'https://europepmc.org/articles/pmc1563505?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563505', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16940111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00394-06', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1494581922', 'https://openalex.org/W1512031035', 'https://openalex.org/W1594700207', 'https://openalex.org/W1617412318', 'https://openalex.org/W162317852', 'https://openalex.org/W175983246', 'https://openalex.org/W1830555632', 'https://openalex.org/W1971594953', 'https://openalex.org/W1991499538', 'https://openalex.org/W1992233431', 'https://openalex.org/W1994196028', 'https://openalex.org/W1998567654', 'https://openalex.org/W2009281834', 'https://openalex.org/W2018940251', 'https://openalex.org/W2019851585', 'https://openalex.org/W2020251171', 'https://openalex.org/W2030773468', 'https://openalex.org/W2048654890', 'https://openalex.org/W2049679577', 'https://openalex.org/W2053326299', 'https://openalex.org/W2060211917', 'https://openalex.org/W2063248255', 'https://openalex.org/W2067428749', 'https://openalex.org/W2069737965', 'https://openalex.org/W2070828985', 'https://openalex.org/W2085326030', 'https://openalex.org/W2085988098', 'https://openalex.org/W2097343186', 'https://openalex.org/W2101847661', 'https://openalex.org/W2102431991', 'https://openalex.org/W2105668259', 'https://openalex.org/W2105801894', 'https://openalex.org/W2107096299', 'https://openalex.org/W2112047656', 'https://openalex.org/W2124397518', 'https://openalex.org/W2132285289', 'https://openalex.org/W2132608735', 'https://openalex.org/W2134213012', 'https://openalex.org/W2144368255', 'https://openalex.org/W2150926065', 'https://openalex.org/W2169812632', 'https://openalex.org/W2171920878', 'https://openalex.org/W2415675882', 'https://openalex.org/W2791114118', 'https://openalex.org/W2799058653', 'https://openalex.org/W281861915', 'https://openalex.org/W4232357596', 'https://openalex.org/W4248713218', 'https://openalex.org/W4294253619'], 'related_works': ['https://openalex.org/W4256246041', 'https://openalex.org/W2845285504', 'https://openalex.org/W2538215728', 'https://openalex.org/W2472737120', 'https://openalex.org/W2412157758', 'https://openalex.org/W2150561065', 'https://openalex.org/W2100109140', 'https://openalex.org/W2009850071', 'https://openalex.org/W1998121672', 'https://openalex.org/W1998059890'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Tetracyclines': [1], 'are': [2], 'effective': [3], 'but': [4, 87, 195], 'slow-acting': [5], 'antimalarial': [6, 17, 197], 'drugs': [7, 64], 'whose': [8], 'mechanism': [9, 18], 'of': [10, 19, 70, 85, 98, 109, 118, 132, 134, 147, 166, 174, 182, 188], 'action': [11], 'remains': [12], 'uncertain.': [13], 'To': [14], 'characterize': [15], 'the': [16, 37, 40, 63, 68, 71, 82, 96, 107, 116, 148, 167, 172, 186], 'tetracyclines,': [20], 'we': [21], 'evaluated': [22], 'their': [23], 'stage-specific': [24], 'activities,': [25], 'impacts': [26], 'on': [27, 32], 'parasite': [28], 'transcription,': [29], 'and': [30, 39, 138, 142, 150, 153], 'effects': [31, 48], 'two': [33, 53], 'predicted': [34], 'organelle': [35], 'targets,': [36], 'apicoplast': [38, 99, 127, 168, 183], 'mitochondrion,': [41], 'in': [42, 81, 106, 115, 126, 171, 185], 'cultured': [43], 'Plasmodium': [44], 'falciparum': [45], '.': [46], 'Antimalarial': [47], 'were': [49, 65, 113], 'much': [50], 'greater': [51], 'after': [52, 58], '48-h': [54], 'life': [55], 'cycles': [56], 'than': [57], 'one': [59], 'cycle,': [60], 'even': [61], 'if': [62], 'removed': [66], 'at': [67], 'end': [69], 'first': [72], 'cycle.': [73], 'Doxycycline-treated': [74], 'parasites': [75, 190], 'appeared': [76, 104, 156], 'morphologically': [77], 'normal': [78, 105], 'until': [79], 'late': [80], 'second': [83], 'cycle': [84], 'treatment': [86], 'failed': [88], 'to': [89, 140, 192], 'develop': [90], 'into': [91, 177], 'merozoites.': [92, 179], 'Doxycycline': [93], 'specifically': [94, 163], 'impaired': [95], 'expression': [97, 165], 'genes.': [100], 'Apicoplast': [101], 'morphology': [102, 155], 'initially': [103], 'presence': [108], 'doxycycline.': [110], 'However,': [111], 'apicoplasts': [112, 176], 'abnormal': [114], 'progeny': [117, 187], 'doxycycline-treated': [119], 'parasites,': [120], 'as': [121], 'evidenced': [122], 'by': [123], 'a': [124, 130, 193], 'block': [125, 164], 'genome': [128], 'replication,': [129], 'lack': [131], 'processing': [133], 'an': [135], 'apicoplast-targeted': [136], 'protein,': [137], 'failure': [139], 'elongate': [141], 'segregate': [143], 'during': [144], 'schizogeny.': [145], 'Replication': [146], 'nuclear': [149], 'mitochondrial': [151, 154], 'genomes': [152], 'normal.': [157], 'Our': [158], 'results': [159], 'demonstrate': [160], 'that': [161], 'tetracyclines': [162], 'genome,': [169], 'resulting': [170], 'distribution': [173], 'nonfunctional': [175], 'daughter': [178], 'The': [180], 'loss': [181], 'function': [184], 'treated': [189], 'leads': [191], 'slow': [194], 'potent': [196], 'effect.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082992930', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-24T14:36:49.348468', 'created_date': '2016-06-24'}