Title: Malignant myoepithelioma of the breast: An immunohistochemical study by light and electron microscopy
Abstract: CancerVolume 57, Issue 4 p. 745-750 ArticleFree Access Malignant myoepithelioma of the breast: An immunohistochemical study by light and electron microscopy Paul S. Thorner MD, Corresponding Author Paul S. Thorner MD Department of Pathology, The Hospital for Sick Children, Ontario, CanadaDepartment of Pathology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8===Search for more papers by this authorHarriette J. Kahn MD, Harriette J. Kahn MD Department of Pathology, The Hospital for Sick Children, Ontario, Canada Department of Pathology, Women's College Hospital Departments of Pathology, Ontario, CanadaSearch for more papers by this authorReuben Baumal MD, PhD, Reuben Baumal MD, PhD Department of Pathology, The Hospital for Sick Children, Ontario, CanadaSearch for more papers by this authorKing Lee MD, King Lee MD Surgery, Humber Memorial Hospital Toronto, Ontario, CanadaSearch for more papers by this authorWilliam Moffatt MD, William Moffatt MD Prepared with the assistance of the Medical Publications Department, The Hospital for Sick Children, CanadaSearch for more papers by this author Paul S. Thorner MD, Corresponding Author Paul S. Thorner MD Department of Pathology, The Hospital for Sick Children, Ontario, CanadaDepartment of Pathology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8===Search for more papers by this authorHarriette J. Kahn MD, Harriette J. Kahn MD Department of Pathology, The Hospital for Sick Children, Ontario, Canada Department of Pathology, Women's College Hospital Departments of Pathology, Ontario, CanadaSearch for more papers by this authorReuben Baumal MD, PhD, Reuben Baumal MD, PhD Department of Pathology, The Hospital for Sick Children, Ontario, CanadaSearch for more papers by this authorKing Lee MD, King Lee MD Surgery, Humber Memorial Hospital Toronto, Ontario, CanadaSearch for more papers by this authorWilliam Moffatt MD, William Moffatt MD Prepared with the assistance of the Medical Publications Department, The Hospital for Sick Children, CanadaSearch for more papers by this author First published: 15 February 1986 https://doi.org/10.1002/1097-0142(19860215)57:4<745::AID-CNCR2820570411>3.0.CO;2-8Citations: 72AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Myoepitheliomas of the breast are extremely rare; only four cases have been reported to date. It is not clear whether these tumors behave in a benign or malignant fashion, and no metastatic spread has been documented. We report a myoepithelioma of the breast with metastatic spread to an axillary lymph node. Myoepithelial cell (MEC) differentiation in the tumor was characterized using electron microscopic (EM) criteria. Immunologic investigations at the LM and EM levels showed that the tumor cells were positive for S100 protein, actin, and epidermal cytokeratin; these findings are indicative of MEC differentiation. By immuno-EM, cytokeratin filaments were present in a perinuclear location, while actin filaments were concentrated along the cell periphery. To the authors' knowledge, this is the first report of a breast myoepithelioma that has metastasized and also the first report of the immunologic characterization of a myoepithelioma at the light and electron microscopic levels. References 1 Chaudhry AP, Satchidanand S, Peer R, Cutler DDS. Myoepithelial cell adenoma of the parotid gland: A light and ultrastructural study. Cancer 1982; 49: 288– 293. 2 Crissman JD, Wirman JA, Harris A. Malignant myoepithelioma of the parotid gland. Cancer 1977; 40: 3042– 3049. 3 Sciubba JJ, Brannon RB. Myoepithelioma of salivary glands: Report of 23 cases. Cancer 1982; 49: 562– 572. 4 Cameron HM, Hamperl H, Warambo W. Leiomyosarcoma of the breast originating from myothelium (Myoepithelium). J Pathol 1974; 114: 89– 92. 5 Erlandson RA, Rosen PP. Infiltrating myoepithelioma of the breast. Am J Surg Pathol 1982; 6: 785– 793. 6 Toth J: Benign human mammary myoepithelioma. Virchows Arch [Path Anat] 1977; 374: 263– 269. 7 Zarbo RJ, Oberman HA. Cellular adenomyoepithelioma of the breast. Am J Surg Pathol 1983; 7: 863– 870. 8 Franke WW, Schmid E, Freudenstein C et al. Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J Cell Biol 1980; 84: 633– 654. 9 Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 1970; 18: 315– 333. 10 Labourdette G, Marks A. Synthesis of S-100 protein in monolayer cultures of rat-glial cells. Eur J Biochem 1975; 58: 73– 79. 11 Huiatt TW, Robson RM, Arakawa N, Stromer MH. Desmin from avian smooth muscle: purification and partial characterization. J Biol Chem 1980; 255: 6981– 6989. 12 Horisberger M. Evaluation of colloidal gold as a cytochemical marker for transmission and scanning electron microscopy. Biol Cell 1979; 36: 253– 258. 13 McDivitt RS, Stewart FW, Berg JW. Tumors of the breast. In: Atlas of Tumor Pathology, Series 2, Fasc. 2. Washington, DC: Armed Forces Institute of Pathology, 1968; 94– 100, 123–125. 14 Bogomoletz WV, Boulenger E, Simatos A. Infiltrating fibromatosis of the breast. J Clin Pathol 1981; 34: 30– 34. 15 Berg JW, DeCrosse JJ, Fracchia AA, Farrow J. Stromal sarcomas of the breast: A unified approach to connective tissue sarcomas other than cystosarcoma phyllodes. Cancer 1962; 15: 418– 424. 16 Tang PH, Petrelli M, Robechek PJ. Stromal sarcoma of the breast: A light and electron microscopic study. Cancer 1979; 43: 209– 217. 17 Toker C, Tang CK, White JF, Berkheiser SW, Rachman R. Benign spindle cell breast tumor. Cancer 1981; 48: 1615– 1622. 18 Mukai K, Schollmeyer JV, Rosai J. Immunohistochemical localization of actin: Applications in surgical pathology. Am J Surg Pathol 1981; 5: 91– 97. 19 Kahn HJ, Marks A, Thom H, Baumal R. Role of antibody to S100 protein in diagnostic pathology. Am J Clin Pathol 1983; 79: 341– 347. 20 Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y. An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol 1982; 6: 715– 727. Citing Literature Volume57, Issue415 February 1986Pages 745-750 ReferencesRelatedInformation