Title: Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers.
Abstract: The comparative effect of famotidine or cimetidine on theophylline disposition was determined in healthy volunteers. Cimetidine, but not famotidine, caused a reduction in the rate of elimination of theophylline. The mean total body clearance of theophylline was reduced from 57.6 ml min‐1 before cimetidine to 39.5 ml min‐1 during cimetidine; and the half‐life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine. The volume of distribution and renal excretion of theophylline were not affected by either famotidine or cimetidine.