Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2062400828', 'doi': 'https://doi.org/10.1038/nprot.2010.127', 'title': 'Synthesis of peptide macrocycles using unprotected amino aldehydes', 'display_name': 'Synthesis of peptide macrocycles using unprotected amino aldehydes', 'publication_year': 2010, 'publication_date': '2010-10-21', 'ids': {'openalex': 'https://openalex.org/W2062400828', 'doi': 'https://doi.org/10.1038/nprot.2010.127', 'mag': '2062400828', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21030956'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nprot.2010.127', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S109387254', 'display_name': 'Nature Protocols', 'issn_l': '1750-2799', 'issn': ['1750-2799', '1754-2189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007701258', 'display_name': 'Benjamin H. Rotstein', 'orcid': 'https://orcid.org/0000-0001-9707-9357'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Benjamin H Rotstein', 'raw_affiliation_strings': ['Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027004184', 'display_name': 'Vishal Rai', 'orcid': 'https://orcid.org/0000-0002-6078-3516'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Vishal Rai', 'raw_affiliation_strings': ['Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049870216', 'display_name': 'Ryan Hili', 'orcid': 'https://orcid.org/0000-0002-8933-970X'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ryan Hili', 'raw_affiliation_strings': ['Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada', 'Present address: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.,'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Present address: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.,', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081408580', 'display_name': 'Andrei K. Yudin', 'orcid': 'https://orcid.org/0000-0003-3170-9103'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Andrei K Yudin', 'raw_affiliation_strings': ['Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Davenport Research Laboratories, University of Toronto, Toronto, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.955, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.774791, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '5', 'issue': '11', 'first_page': '1813', 'last_page': '1822'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry in Chemical Biology and Drug Development', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12251', 'display_name': 'Catalytic C-H Amination Reactions', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aziridine', 'display_name': 'Aziridine', 'score': 0.958619}, {'id': 'https://openalex.org/keywords/peptide-synthesis', 'display_name': 'Peptide Synthesis', 'score': 0.546323}, {'id': 'https://openalex.org/keywords/macrocycles', 'display_name': 'Macrocycles', 'score': 0.527641}], 'concepts': [{'id': 'https://openalex.org/C2778544067', 'wikidata': 'https://www.wikidata.org/wiki/Q409141', 'display_name': 'Aziridine', 'level': 3, 'score': 0.958619}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.74724996}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.72601527}, {'id': 'https://openalex.org/C178907741', 'wikidata': 'https://www.wikidata.org/wiki/Q745930', 'display_name': 'Nucleophile', 'level': 3, 'score': 0.64430094}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.60553616}, {'id': 'https://openalex.org/C2779825165', 'wikidata': 'https://www.wikidata.org/wiki/Q101497', 'display_name': 'Aldehyde', 'level': 3, 'score': 0.5181397}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.49179652}, {'id': 'https://openalex.org/C40875361', 'wikidata': 'https://www.wikidata.org/wiki/Q2356542', 'display_name': 'Reagent', 'level': 2, 'score': 0.48401162}, {'id': 'https://openalex.org/C2780378348', 'wikidata': 'https://www.wikidata.org/wiki/Q25351438', 'display_name': 'Ring (chemistry)', 'level': 2, 'score': 0.46137393}, {'id': 'https://openalex.org/C2779809887', 'wikidata': 'https://www.wikidata.org/wiki/Q14864278', 'display_name': 'Peptide synthesis', 'level': 3, 'score': 0.44045258}, {'id': 'https://openalex.org/C2777010268', 'wikidata': 'https://www.wikidata.org/wiki/Q421897', 'display_name': 'Isocyanide', 'level': 2, 'score': 0.43029535}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.30261284}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.28613943}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.094213605}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.06119749}], 'mesh': [{'descriptor_ui': 'D047028', 'descriptor_name': 'Macrocyclic Compounds', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000447', 'descriptor_name': 'Aldehydes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000447', 'descriptor_name': 'Aldehydes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001388', 'descriptor_name': 'Aziridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001388', 'descriptor_name': 'Aziridines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003486', 'descriptor_name': 'Cyanides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003486', 'descriptor_name': 'Cyanides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047028', 'descriptor_name': 'Macrocyclic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nprot.2010.127', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S109387254', 'display_name': 'Nature Protocols', 'issn_l': '1750-2799', 'issn': ['1750-2799', '1754-2189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21030956', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.52, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1507863951', 'https://openalex.org/W1590076690', 'https://openalex.org/W1965819962', 'https://openalex.org/W1971652833', 'https://openalex.org/W1973269565', 'https://openalex.org/W1973605798', 'https://openalex.org/W1973713421', 'https://openalex.org/W1974449288', 'https://openalex.org/W1992673544', 'https://openalex.org/W1999253307', 'https://openalex.org/W2000574656', 'https://openalex.org/W2007204368', 'https://openalex.org/W2013525448', 'https://openalex.org/W2016965530', 'https://openalex.org/W2018105404', 'https://openalex.org/W2027289641', 'https://openalex.org/W2028123697', 'https://openalex.org/W2030938199', 'https://openalex.org/W2031261222', 'https://openalex.org/W2033347874', 'https://openalex.org/W2040156588', 'https://openalex.org/W2040576705', 'https://openalex.org/W2045093121', 'https://openalex.org/W2046549433', 'https://openalex.org/W2053698356', 'https://openalex.org/W2062835263', 'https://openalex.org/W2072816179', 'https://openalex.org/W2076876448', 'https://openalex.org/W2078120062', 'https://openalex.org/W2079223134', 'https://openalex.org/W2100516474', 'https://openalex.org/W2107005517', 'https://openalex.org/W2111677437', 'https://openalex.org/W2137932674', 'https://openalex.org/W2140834026', 'https://openalex.org/W2146965998', 'https://openalex.org/W2152153809', 'https://openalex.org/W2153870552', 'https://openalex.org/W2314401973', 'https://openalex.org/W2951274897', 'https://openalex.org/W2951819737', 'https://openalex.org/W53577214', 'https://openalex.org/W592757206'], 'related_works': ['https://openalex.org/W74890541', 'https://openalex.org/W3133767786', 'https://openalex.org/W2951658419', 'https://openalex.org/W2915613132', 'https://openalex.org/W2614576422', 'https://openalex.org/W2345897290', 'https://openalex.org/W2040620122', 'https://openalex.org/W2037963256', 'https://openalex.org/W2029750839', 'https://openalex.org/W2010821211'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062400828', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-09-24T08:32:57.912409', 'created_date': '2016-06-24'}