Title: Colony-forming units and survival of irradiated mice treated with AET or endotoxin.
Abstract: When mice are given radiation exposures producing the hematopoietic syndrome, it is assumed that it is the killing of hematopoietic stem cells and the leuko- and thrombocytopenias which ultimately develop that predispose the animals to infection, hemorrhage and death. The colony-forming unit (CFU) has many attributes of a (the) hematopoietic stem cell, and it might be expected that a high correlation should exist between CFU survival and survival of the animal. Some earlier studies have supported this correlation, whereas, others have not. In the present experiments three CFU methods (endogenous, recipient, and donor) have been used to evaluate this correlation in mice in which survival has been increased with AET or bacterial endotoxin. The results show that the different CFU procedures yield somewhat different results, yet under certain conditions the LD50's for AET- or endotoxin-treated mice may be predicted within 2-10% from CFU survival curves. In spite of the good correlation between CFU survival an...
Publication Year: 1969
Publication Date: 1969-10-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 22
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot