Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2058953699', 'doi': 'https://doi.org/10.1093/nar/gkr805', 'title': 'Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex', 'display_name': 'Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex', 'publication_year': 2011, 'publication_date': '2011-10-03', 'ids': {'openalex': 'https://openalex.org/W2058953699', 'doi': 'https://doi.org/10.1093/nar/gkr805', 'mag': '2058953699', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21967848', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3273806'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/nar/gkr805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3273806?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040871390', 'display_name': 'Yuji Masuda', 'orcid': 'https://orcid.org/0000-0002-6229-1988'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Masuda', 'raw_affiliation_strings': ['Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Minami-ku, Hiroshima, 734–8553, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Minami-ku, Hiroshima, 734–8553, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109285110', 'display_name': 'Miki Suzuki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Miki Suzuki', 'raw_affiliation_strings': ['Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050848335', 'display_name': 'Hidehiko Kawai', 'orcid': 'https://orcid.org/0000-0003-2213-7166'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidehiko Kawai', 'raw_affiliation_strings': ['Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103073760', 'display_name': 'Fumio Suzuki', 'orcid': 'https://orcid.org/0000-0003-4072-732X'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumio Suzuki', 'raw_affiliation_strings': ['Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001973313', 'display_name': 'Kenji Kamiya', 'orcid': 'https://orcid.org/0000-0001-9449-5910'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Kamiya', 'raw_affiliation_strings': ['Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.907, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.903491, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '40', 'issue': '3', 'first_page': '1065', 'last_page': '1076'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ubiquitin-protein-ligases', 'display_name': 'Ubiquitin-Protein Ligases', 'score': 0.7854065}, {'id': 'https://openalex.org/keywords/ternary-complex', 'display_name': 'Ternary complex', 'score': 0.63290274}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.88966}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.8136468}, {'id': 'https://openalex.org/C2908868211', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin-Protein Ligases', 'level': 5, 'score': 0.7854065}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.6361174}, {'id': 'https://openalex.org/C86756495', 'wikidata': 'https://www.wikidata.org/wiki/Q7702931', 'display_name': 'Ternary complex', 'level': 3, 'score': 0.63290274}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.5748174}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.56448585}, {'id': 'https://openalex.org/C2780378348', 'wikidata': 'https://www.wikidata.org/wiki/Q25351438', 'display_name': 'Ring (chemistry)', 'level': 2, 'score': 0.4642542}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35662544}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34572995}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33648092}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.32379925}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.13311777}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0741967}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/nar/gkr805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3273806', 'pdf_url': 'https://europepmc.org/articles/pmc3273806?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://ir.lib.hiroshima-u.ac.jp/00033900', 'pdf_url': 'https://ir.lib.hiroshima-u.ac.jp/33900/files/30722', 'source': {'id': 'https://openalex.org/S4377196292', 'display_name': 'Hiroshima University Acedemic Information Repository (Hiroshima University)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I113306721', 'host_organization_name': 'Hiroshima University', 'host_organization_lineage': ['https://openalex.org/I113306721'], 'host_organization_lineage_names': ['Hiroshima University'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273806', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21967848', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3273806', 'pdf_url': 'https://europepmc.org/articles/pmc3273806?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1491876634', 'https://openalex.org/W1873199501', 'https://openalex.org/W1902704112', 'https://openalex.org/W1967531650', 'https://openalex.org/W1980578402', 'https://openalex.org/W1982782744', 'https://openalex.org/W1982914598', 'https://openalex.org/W1986293877', 'https://openalex.org/W1989054182', 'https://openalex.org/W1996462501', 'https://openalex.org/W1997220554', 'https://openalex.org/W2003245647', 'https://openalex.org/W2003928652', 'https://openalex.org/W2010516573', 'https://openalex.org/W2011580988', 'https://openalex.org/W2015291446', 'https://openalex.org/W2019683899', 'https://openalex.org/W2020136215', 'https://openalex.org/W2021110075', 'https://openalex.org/W2022787288', 'https://openalex.org/W2029084823', 'https://openalex.org/W2029709752', 'https://openalex.org/W2037909746', 'https://openalex.org/W2039931633', 'https://openalex.org/W2046135777', 'https://openalex.org/W2047063821', 'https://openalex.org/W2047368106', 'https://openalex.org/W2048162805', 'https://openalex.org/W2048712749', 'https://openalex.org/W2049717891', 'https://openalex.org/W2054918042', 'https://openalex.org/W2059164909', 'https://openalex.org/W2068638854', 'https://openalex.org/W2072286806', 'https://openalex.org/W2073294832', 'https://openalex.org/W2078411081', 'https://openalex.org/W2093984973', 'https://openalex.org/W2096787803', 'https://openalex.org/W2100443229', 'https://openalex.org/W2101101375', 'https://openalex.org/W2103678021', 'https://openalex.org/W2104061629', 'https://openalex.org/W2108490141', 'https://openalex.org/W2119301405', 'https://openalex.org/W2131510695', 'https://openalex.org/W2141115493', 'https://openalex.org/W2144114582', 'https://openalex.org/W2146149989', 'https://openalex.org/W2146497742', 'https://openalex.org/W2154773687', 'https://openalex.org/W2157237244', 'https://openalex.org/W2158330526', 'https://openalex.org/W2161828378', 'https://openalex.org/W2169950973', 'https://openalex.org/W2170517581'], 'related_works': ['https://openalex.org/W4323034334', 'https://openalex.org/W4214895574', 'https://openalex.org/W3212514911', 'https://openalex.org/W295190513', 'https://openalex.org/W2797773019', 'https://openalex.org/W2558779466', 'https://openalex.org/W2149470445', 'https://openalex.org/W2054919679', 'https://openalex.org/W1998829023', 'https://openalex.org/W1970861248'], 'abstract_inverted_index': {'RAD18,': [0], 'a': [1, 28, 48, 76, 106, 125], 'RING-type': [2], 'ubiquitin': [3], 'ligase': [4, 100, 103, 152], '(E3)': [5], 'that': [6, 71, 137], 'plays': [7], 'an': [8, 31, 168], 'essential': [9], 'role': [10], 'in': [11, 39, 87, 122, 139, 156, 176], 'post-replication': [12], 'repair,': [13], 'possesses': [14], 'distinct': [15], 'domains': [16], 'named': [17], 'RING,': [18], 'UBZ,': [19, 149], 'SAP': [20], 'and': [21, 26, 63, 73, 80, 98], 'the': [22, 40, 53, 81, 88, 99, 172, 177], 'RAD6-binding': [23], 'domain': [24], '(R6BD)': [25], 'forms': [27], 'dimer.': [29], 'RAD6,': [30], 'ubiquitin-conjugating': [32], 'enzyme': [33], '(E2),': [34], 'stably': [35], 'associates': [36], 'with': [37, 116, 132], 'R6BD': [38, 86], 'C-terminal': [41], 'portion.': [42], 'In': [43], 'this': [44], 'study,': [45], 'we': [46], 'established': [47], 'method': [49], 'to': [50], 'distinguish': [51], 'between': [52], 'two': [54, 89, 160, 173], 'subunits': [55, 91, 141, 161, 175], 'of': [56, 60, 83, 105, 119, 142, 159, 171], 'RAD18': [57, 74, 90, 174], 'by': [58], 'introduction': [59], 'different': [61], 'tags,': [62], 'analyzed': [64], 'mutant': [65, 107], 'complexes.': [66], 'Our': [67], 'results,': [68], 'surprisingly,': [69], 'demonstrate': [70], 'RAD6A': [72, 120], 'form': [75], 'ternary': [77, 95], 'complex,': [78], 'RAD6A–(RAD18)2': [79], 'presence': [82], 'only': [84, 157], 'one': [85, 158], 'is': [92, 112, 162], 'sufficient': [93], 'for': [94, 127], 'complex': [96], 'formation': [97], 'activity.': [101], 'Interestingly,': [102], 'activity': [104], 'dimer': [108], 'lacking': [109], 'both': [110, 140], 'R6BDs': [111], 'not': [113, 148], 'restored': [114], 'even': [115], 'large': [117], 'amounts': [118], 'added': [121], 'solution,': [123], 'suggesting': [124], 'requirement': [126], 'precise': [128], 'juxtaposition': [129], 'via': [130], 'interaction': [131], 'R6BD.': [133], 'We': [134], 'further': [135], 'show': [136], 'mutations': [138], 'either': [143], 'RING': [144], 'or': [145], 'SAP,': [146], 'but': [147], 'strongly': [150], 'reduce': [151], 'activity,': [153], 'although': [154], 'inactivation': [155], 'without': [163], 'effect.': [164], 'These': [165], 'results': [166], 'suggest': [167], 'asymmetric': [169], 'nature': [170], 'complex.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058953699', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-12T13:58:24.229112', 'created_date': '2016-06-24'}