Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2057598559', 'doi': 'https://doi.org/10.1021/bi00149a022', 'title': 'Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction', 'display_name': 'Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction', 'publication_year': 1992, 'publication_date': '1992-09-01', 'ids': {'openalex': 'https://openalex.org/W2057598559', 'doi': 'https://doi.org/10.1021/bi00149a022', 'mag': '2057598559', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1324722'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi00149a022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035269972', 'display_name': 'Linda C. Kurz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Linda C. Kurz', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078389640', 'display_name': 'Saurabh Shah', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Saurabh Shah', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071526287', 'display_name': 'Brian R. Crane', 'orcid': 'https://orcid.org/0000-0001-8234-9991'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian R. Crane', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088096211', 'display_name': 'Lynda J. Donald', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lynda J. Donald', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003079033', 'display_name': 'Harry W. Duckworth', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Harry W. Duckworth', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031087532', 'display_name': 'George R. Drysdale', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'George R. Drysdale', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.22, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.798258, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '31', 'issue': '34', 'first_page': '7899', 'last_page': '7907'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10932', 'display_name': 'Microbial Metabolic Engineering and Bioproduction', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transition-state-analog', 'display_name': 'Transition state analog', 'score': 0.74869156}, {'id': 'https://openalex.org/keywords/dissociation-constant', 'display_name': 'Dissociation constant', 'score': 0.6832366}, {'id': 'https://openalex.org/keywords/ternary-complex', 'display_name': 'Ternary complex', 'score': 0.55810595}], 'concepts': [{'id': 'https://openalex.org/C13053905', 'wikidata': 'https://www.wikidata.org/wiki/Q17087414', 'display_name': 'Transition state analog', 'level': 4, 'score': 0.74869156}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7407762}, {'id': 'https://openalex.org/C111133373', 'wikidata': 'https://www.wikidata.org/wiki/Q21132608', 'display_name': 'Citrate synthase', 'level': 3, 'score': 0.7243978}, {'id': 'https://openalex.org/C74998103', 'wikidata': 'https://www.wikidata.org/wiki/Q898254', 'display_name': 'Dissociation constant', 'level': 3, 'score': 0.6832366}, {'id': 'https://openalex.org/C30095370', 'wikidata': 'https://www.wikidata.org/wiki/Q899488', 'display_name': 'Protonation', 'level': 3, 'score': 0.60458815}, {'id': 'https://openalex.org/C86756495', 'wikidata': 'https://www.wikidata.org/wiki/Q7702931', 'display_name': 'Ternary complex', 'level': 3, 'score': 0.55810595}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.46311513}, {'id': 'https://openalex.org/C64452783', 'wikidata': 'https://www.wikidata.org/wiki/Q1524945', 'display_name': 'Ternary operation', 'level': 2, 'score': 0.4509423}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.37218916}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.24807566}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22681993}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.14190862}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000105', 'descriptor_name': 'Acetyl Coenzyme A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000214', 'descriptor_name': 'Acyl Coenzyme A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010071', 'descriptor_name': 'Oxaloacetates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011522', 'descriptor_name': 'Protons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000105', 'descriptor_name': 'Acetyl Coenzyme A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000214', 'descriptor_name': 'Acyl Coenzyme A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007526', 'descriptor_name': 'Isoelectric Point', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010071', 'descriptor_name': 'Oxaloacetates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi00149a022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1324722', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1496938093', 'https://openalex.org/W1574451580', 'https://openalex.org/W1589428865', 'https://openalex.org/W1607852746', 'https://openalex.org/W191732914', 'https://openalex.org/W1976424441', 'https://openalex.org/W1977348707', 'https://openalex.org/W1978430480', 'https://openalex.org/W1979650928', 'https://openalex.org/W1982084333', 'https://openalex.org/W1982102396', 'https://openalex.org/W1990491236', 'https://openalex.org/W2011424180', 'https://openalex.org/W2027527603', 'https://openalex.org/W2034889157', 'https://openalex.org/W2037509202', 'https://openalex.org/W2037549407', 'https://openalex.org/W2039989527', 'https://openalex.org/W2042734565', 'https://openalex.org/W2042806005', 'https://openalex.org/W2044571130', 'https://openalex.org/W2049279752', 'https://openalex.org/W2054379970', 'https://openalex.org/W2056698252', 'https://openalex.org/W2059589864', 'https://openalex.org/W2079472772', 'https://openalex.org/W2081328114', 'https://openalex.org/W2083400050', 'https://openalex.org/W2092372554', 'https://openalex.org/W2094357611', 'https://openalex.org/W2104021409', 'https://openalex.org/W2322559777', 'https://openalex.org/W2402871527'], 'related_works': ['https://openalex.org/W945805037', 'https://openalex.org/W2126559590', 'https://openalex.org/W2091247790', 'https://openalex.org/W2090509819', 'https://openalex.org/W2061718200', 'https://openalex.org/W2060044165', 'https://openalex.org/W2048063466', 'https://openalex.org/W2021989727', 'https://openalex.org/W2000394801', 'https://openalex.org/W1973147414'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVArticleNEXTProton': [3], 'uptake': [4], 'accompanies': [5], 'formation': [6], 'of': [7, 11, 30, 85, 120, 146], 'the': [8, 16, 27, 33, 82, 113, 118, 147, 158, 171, 174, 179, 186, 192], 'ternary': [9], 'complex': [10], 'citrate': [12, 34], 'synthase,': [13], 'oxaloacetate,': [14], 'and': [15, 50, 95, 100, 129, 173, 190, 206, 208], 'transition-state': [17], 'analog': [18], 'inhibitor,': [19], 'carboxymethyl-CoA.': [20], 'Evidence': [21], 'that': [22, 149], 'a': [23, 143, 150, 163], 'neutral': [24], 'enol': [25], 'is': [26, 142, 194], 'activated': [28], 'form': [29], 'acetyl-CoA': [31], 'in': [32], 'synthase': [35], 'reactionLinda': [36], 'C.': [37], 'Kurz,': [38], 'Saurabh': [39], 'Shah,': [40], 'Brian': [41], 'R.': [42, 52], 'Crane,': [43], 'Lynda': [44], 'J.': [45], 'Donald,': [46], 'Harry': [47], 'W.': [48], 'Duckworth,': [49], 'George': [51], 'DrysdaleCite': [53], 'this:': [54], 'Biochemistry': [55], '1992,': [56], '31,': [57], '34,': [58], '7899–7907Publication': [59], 'Date': [60], '(Print):September': [61], '1,': [62], '1992Publication': [63], 'History': [64], 'Published': [65], 'online1': [66], 'May': [67], '2002Published': [68], 'inissue': [69], '1': [70], 'September': [71], '1992https://pubs.acs.org/doi/10.1021/bi00149a022https://doi.org/10.1021/bi00149a022research-articleACS': [72], 'PublicationsRequest': [73], 'reuse': [74], 'permissionsArticle': [75], 'Views186Altmetric-Citations17LEARN': [76], 'ABOUT': [77], 'THESE': [78], 'METRICSArticle': [79], 'Views': [80], 'are': [81, 104, 117], 'COUNTER-compliant': [83], 'sum': [84], 'full': [86], 'text': [87], 'article': [88, 152], 'downloads': [89], 'since': [90], 'November': [91], '2008': [92], '(both': [93], 'PDF': [94], 'HTML)': [96], 'across': [97], 'all': [98], 'institutions': [99], 'individuals.': [101], 'These': [102], 'metrics': [103], 'regularly': [105], 'updated': [106, 130], 'to': [107, 112], 'reflect': [108], 'usage': [109], 'leading': [110], 'up': [111], 'last': [114], 'few': [115], 'days.Citations': [116], 'number': [119], 'other': [121], 'articles': [122], 'citing': [123], 'this': [124], 'article,': [125], 'calculated': [126], 'by': [127], 'Crossref': [128, 136], 'daily.': [131], 'Find': [132, 182], 'more': [133, 183], 'information': [134, 184], 'about': [135, 170], 'citation': [137], 'counts.The': [138], 'Altmetric': [139, 187], 'Attention': [140, 188], 'Score': [141, 189], 'quantitative': [144], 'measure': [145], 'attention': [148], 'research': [151], 'has': [153], 'received': [154], 'online.': [155], 'Clicking': [156], 'on': [157, 185], 'donut': [159], 'icon': [160], 'will': [161], 'load': [162], 'page': [164], 'at': [165], 'altmetric.com': [166], 'with': [167, 202], 'additional': [168], 'details': [169], 'score': [172, 193], 'social': [175], 'media': [176], 'presence': [177], 'for': [178], 'given': [180], 'article.': [181], 'how': [191], 'calculated.': [195], 'Share': [196, 211], 'Add': [197], 'toView': [198], 'InAdd': [199], 'Full': [200], 'Text': [201], 'ReferenceAdd': [203], 'Description': [204], 'ExportRISCitationCitation': [205], 'abstractCitation': [207], 'referencesMore': [209], 'Options': [210], 'onFacebookTwitterWechatLinked': [212], 'InRedditEmail': [213], 'Other': [214], 'access': [215], 'optionsGet': [216], 'e-Alertsclose': [217], 'Get': [218], 'e-Alerts': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057598559', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-09T10:08:15.374139', 'created_date': '2016-06-24'}