Title: Coupling Gating with Ion Permeation in ClC Channels
Abstract: In ClC chloride (Cl – ) channels, unlike cation-selective ion channels, ion permeation is intimately coupled to fast gating. Recent research comparing the crystallographic structure of a bacterial ClC channel with functional studies of a Torpedo ClC channel suggests that gating depends on the negatively charged carboxyl group on a glutamate residue, which blocks the channel pore. In this model, the permeating Cl – competes with the carboxyl group for an anion-binding site in the channel pore. This model of Cl – competition with a glutamate gate helps explain the effect of intracellular Cl – on channel gating; the mechanism underlying the effects of extracellular Cl – , however, remains to be determined, as does the nature of the Cl – channel slow gate.
Publication Year: 2003
Publication Date: 2003-06-24
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 42
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