Title: Evidence against leukotriene-mediation of propranolol-induced airway hyperreactivity to acetylcholine
Abstract: Abstract In unanaesthetized guinea-pigs, propranolol treatment (0.l mg kg−1 i.v.) substantially increased reactivity to intravenous acetylcholine infusion or aerosolized histamine to a comparable degree. Neither BW755c (5 mg kg−1 i.v.), FPL 55712 (1 mg kg−1 i.v.), nor piriprost (5 mg kg−1 i.v.) pretreatment influenced propranolol's effect on muscarinic reactivity although BW755c abolished histaminic hyperreactivity. This suggests that propranolol-induced muscarinic hyperreactivity in the guinea-pig is not mediated by leukotrienes whereas histaminic hyperreactivity may be.
Publication Year: 1986
Publication Date: 1986-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 4
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot