Publication Information

{'id': 'https://openalex.org/W2047436521', 'doi': 'https://doi.org/10.1021/jm00152a009', 'title': 'Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes', 'display_name': 'Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes', 'publication_year': 1986, 'publication_date': '1986-02-01', 'ids': {'openalex': 'https://openalex.org/W2047436521', 'doi': 'https://doi.org/10.1021/jm00152a009', 'mag': '2047436521', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3081721'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00152a009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5098091451', 'display_name': 'Christopher K. Mirabell', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christopher K. Mirabell', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103465098', 'display_name': 'Randall K. Johnson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Randall K. Johnson', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035904705', 'display_name': 'David T. Hill', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David T. Hill', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036331253', 'display_name': 'Leo F. Faucette', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Leo F. Faucette', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031321938', 'display_name': 'Gerald R. Girard', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gerald R. Girard', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014481950', 'display_name': 'George Y. Kuo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'George Y. Kuo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080933041', 'display_name': 'Chiu-Mei Sung', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chiu Mei Sung', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077755519', 'display_name': 'Stanley T. Crooke', 'orcid': 'https://orcid.org/0000-0002-4260-1520'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Stanley T. Crooke', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.891, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 223, 'citation_normalized_percentile': {'value': 0.995169, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '29', 'issue': '2', 'first_page': '218', 'last_page': '223'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10163', 'display_name': 'Platinum-Based Cancer Chemotherapy', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10163', 'display_name': 'Platinum-Based Cancer Chemotherapy', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13833', 'display_name': 'Bioorganometallic Chemistry of Ferrocene Derivatives', 'score': 0.977, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12458', 'display_name': 'Chemistry and Biological Activities of Organotin Compounds', 'score': 0.9604, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/auranofin', 'display_name': 'Auranofin', 'score': 0.7633022}, {'id': 'https://openalex.org/keywords/structure–activity-relationship', 'display_name': 'Structure–activity relationship', 'score': 0.5488801}, {'id': 'https://openalex.org/keywords/antitumor-agents', 'display_name': 'Antitumor Agents', 'score': 0.514185}, {'id': 'https://openalex.org/keywords/cytotoxicity', 'display_name': 'Cytotoxicity', 'score': 0.503305}], 'concepts': [{'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.92382145}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.8194115}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.79060596}, {'id': 'https://openalex.org/C2776243873', 'wikidata': 'https://www.wikidata.org/wiki/Q421230', 'display_name': 'Auranofin', 'level': 3, 'score': 0.7633022}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.6770928}, {'id': 'https://openalex.org/C57992300', 'wikidata': 'https://www.wikidata.org/wiki/Q2066956', 'display_name': 'Potency', 'level': 3, 'score': 0.6749891}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.6620983}, {'id': 'https://openalex.org/C193042331', 'wikidata': 'https://www.wikidata.org/wiki/Q1772003', 'display_name': 'Structure–activity relationship', 'level': 3, 'score': 0.5488801}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4826658}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.43775827}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32773596}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16895708}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.12433547}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006046', 'descriptor_name': 'Gold', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001310', 'descriptor_name': 'Auranofin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006051', 'descriptor_name': 'Aurothioglucose', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006051', 'descriptor_name': 'Aurothioglucose', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D006051', 'descriptor_name': 'Aurothioglucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006046', 'descriptor_name': 'Gold', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007941', 'descriptor_name': 'Leukemia P388', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007941', 'descriptor_name': 'Leukemia P388', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00152a009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3081721', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4298385840', 'https://openalex.org/W4237288519', 'https://openalex.org/W3134440503', 'https://openalex.org/W2920199813', 'https://openalex.org/W2411835336', 'https://openalex.org/W2065982408', 'https://openalex.org/W2063446623', 'https://openalex.org/W2057868515', 'https://openalex.org/W2042698681', 'https://openalex.org/W1986935641'], 'abstract_inverted_index': {'A': [0, 40], 'series': [1], 'of': [2, 8, 42, 77, 103, 111, 122, 135], 'gold(I)': [3, 59], 'coordination': [4], 'complexes': [5, 44, 61, 76], 'including': [6], 'analogues': [7], 'the': [9, 43, 57, 63, 78, 84, 87], 'antiarthritic': [10], 'agent': [11], 'auranofin': [12], '1': [13], 'were': [14], 'evaluated': [15], 'for': [16, 74, 86, 97], 'in': [17, 31, 38, 49, 54, 65, 68, 91, 105, 116, 124, 126], 'vitro': [18, 50, 66, 92, 106, 117], 'cytotoxic': [19, 47, 93], 'potency': [20, 104], 'against': [21, 35], 'both': [22], 'B16': [23], 'melanoma': [24], 'cells': [25, 29], 'and': [26, 30, 51, 67, 141], 'P388': [27, 36], 'leukemia': [28, 37], 'vivo': [32, 69, 127], 'antitumor': [33, 52, 112, 128], 'activity': [34, 48, 53, 94, 123, 129], 'mice.': [39], 'number': [41], 'showed': [45], 'potent': [46, 90, 114], 'vivo,': [55, 125], 'with': [56, 109, 137], 'phosphine-coordinated': [58], 'thiosugar': [60], 'demonstrating': [62], 'greatest': [64], 'activity.': [70], 'The': [71], 'data': [72], 'compiled': [73], '63': [75], 'general': [79], 'structural': [80], 'formula': [81], 'LAuX': [82], 'provide': [83], 'basis': [85], 'following': [88], 'observations:': [89], 'is': [95, 118, 130], 'observed': [96], 'substituted': [98, 139], '(phosphine)': [99], 'gold': [100], 'complexes,': [101], 'lack': [102, 110], 'correlates': [107], 'well': [108], 'activity,': [113], 'cytotoxicity': [115], 'not': [119], 'necessarily': [120], 'predictive': [121], 'generally': [131], 'optimized': [132], 'by': [133], 'ligation': [134], 'Au(I)': [136], 'a': [138, 142], 'phosphine': [140], 'thiosugar.': [143]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047436521', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-25T18:59:20.579767', 'created_date': '2016-06-24'}