Publication Information

{'id': 'https://openalex.org/W2042880181', 'doi': 'https://doi.org/10.1016/j.ejphar.2013.02.010', 'title': 'Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5', 'display_name': 'Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5', 'publication_year': 2013, 'publication_date': '2013-02-19', 'ids': {'openalex': 'https://openalex.org/W2042880181', 'doi': 'https://doi.org/10.1016/j.ejphar.2013.02.010', 'mag': '2042880181', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23428631'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2013.02.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072354499', 'display_name': 'Tetsuya Tanigawa', 'orcid': 'https://orcid.org/0000-0002-9305-1637'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Tanigawa', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039509783', 'display_name': 'Toshio Watanabe', 'orcid': 'https://orcid.org/0000-0002-8567-0585'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshio Watanabe', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080368045', 'display_name': 'Koji Otani', 'orcid': 'https://orcid.org/0000-0001-9075-6415'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koji Otani', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007739209', 'display_name': 'Yuji Nadatani', 'orcid': 'https://orcid.org/0000-0001-7081-8746'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Nadatani', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068343767', 'display_name': 'Fumikazu Ohkawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25998863', 'display_name': 'Kyoto Pharmaceutical University', 'ror': 'https://ror.org/01ytgve10', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I25998863']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumikazu Ohkawa', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan', 'Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I25998863']}, {'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066635313', 'display_name': 'Mitsue Sogawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mitsue Sogawa', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081019191', 'display_name': 'Hirokazu Yamagami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirokazu Yamagami', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051481629', 'display_name': 'Masatsugu Shiba', 'orcid': 'https://orcid.org/0000-0002-1512-3965'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masatsugu Shiba', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045329864', 'display_name': 'Kenji Watanabe', 'orcid': 'https://orcid.org/0000-0002-3781-4724'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Watanabe', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000201862', 'display_name': 'Kazunari Tominaga', 'orcid': 'https://orcid.org/0000-0002-9874-1928'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazunari Tominaga', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101917968', 'display_name': 'Yasuhiro Fujiwara', 'orcid': 'https://orcid.org/0000-0002-1225-1785'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuhiro Fujiwara', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090713682', 'display_name': 'Koji Takeuchi', 'orcid': 'https://orcid.org/0000-0002-9668-6021'}, 'institutions': [{'id': 'https://openalex.org/I25998863', 'display_name': 'Kyoto Pharmaceutical University', 'ror': 'https://ror.org/01ytgve10', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I25998863']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koji Takeuchi', 'raw_affiliation_strings': ['Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I25998863']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028746378', 'display_name': 'Tetsuo Arakawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuo Arakawa', 'raw_affiliation_strings': ['Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.', 'institution_ids': ['https://openalex.org/I317356780']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.022, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.864953, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '704', 'issue': '1-3', 'first_page': '64', 'last_page': '69'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13770', 'display_name': 'Impact of Child Care on Infectious Diseases', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/3604', 'display_name': 'Emergency Medical Services'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rebamipide', 'display_name': 'Rebamipide', 'score': 0.9718661}, {'id': 'https://openalex.org/keywords/antimicrobial-peptides', 'display_name': 'Antimicrobial Peptides', 'score': 0.499875}, {'id': 'https://openalex.org/keywords/jejunum', 'display_name': 'Jejunum', 'score': 0.4785843}, {'id': 'https://openalex.org/keywords/paneth-cell', 'display_name': 'Paneth cell', 'score': 0.44689685}], 'concepts': [{'id': 'https://openalex.org/C2777367493', 'wikidata': 'https://www.wikidata.org/wiki/Q7301602', 'display_name': 'Rebamipide', 'level': 2, 'score': 0.9718661}, {'id': 'https://openalex.org/C2776498113', 'wikidata': 'https://www.wikidata.org/wiki/Q412820', 'display_name': 'Defensin', 'level': 3, 'score': 0.67899084}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.6323819}, {'id': 'https://openalex.org/C2777882243', 'wikidata': 'https://www.wikidata.org/wiki/Q11090', 'display_name': 'Small intestine', 'level': 2, 'score': 0.604063}, {'id': 'https://openalex.org/C2776366702', 'wikidata': 'https://www.wikidata.org/wiki/Q185765', 'display_name': 'Jejunum', 'level': 2, 'score': 0.4785843}, {'id': 'https://openalex.org/C2776145723', 'wikidata': 'https://www.wikidata.org/wiki/Q2004084', 'display_name': 'Paneth cell', 'level': 3, 'score': 0.44689685}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.43490726}, {'id': 'https://openalex.org/C539455810', 'wikidata': 'https://www.wikidata.org/wiki/Q739734', 'display_name': 'Gut flora', 'level': 2, 'score': 0.41846484}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40612388}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.39399898}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33149034}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32988214}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32162604}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31657308}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25217575}, {'id': 'https://openalex.org/C4937899', 'wikidata': 'https://www.wikidata.org/wiki/Q68541106', 'display_name': 'Antimicrobial', 'level': 2, 'score': 0.21262869}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21081772}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08036935}], 'mesh': [{'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D023084', 'descriptor_name': 'alpha-Defensins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007213', 'descriptor_name': 'Indomethacin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007213', 'descriptor_name': 'Indomethacin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': False}, {'descriptor_ui': 'D054892', 'descriptor_name': 'Metagenome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023084', 'descriptor_name': 'alpha-Defensins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2013.02.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23428631', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1970396767', 'https://openalex.org/W1970430697', 'https://openalex.org/W1979887480', 'https://openalex.org/W1988082133', 'https://openalex.org/W1990120663', 'https://openalex.org/W2002924275', 'https://openalex.org/W2015341180', 'https://openalex.org/W201850683', 'https://openalex.org/W2036112383', 'https://openalex.org/W2036389069', 'https://openalex.org/W2050501343', 'https://openalex.org/W2052727848', 'https://openalex.org/W2054305086', 'https://openalex.org/W2054646626', 'https://openalex.org/W2068338895', 'https://openalex.org/W2082950723', 'https://openalex.org/W2117130914', 'https://openalex.org/W2122447338', 'https://openalex.org/W2142487570', 'https://openalex.org/W2147378425', 'https://openalex.org/W2162421881', 'https://openalex.org/W2169330513'], 'related_works': ['https://openalex.org/W2626079707', 'https://openalex.org/W2368268786', 'https://openalex.org/W2335396893', 'https://openalex.org/W2260138465', 'https://openalex.org/W2121376495', 'https://openalex.org/W2110521139', 'https://openalex.org/W2109399348', 'https://openalex.org/W2102764783', 'https://openalex.org/W2076916880', 'https://openalex.org/W2015838969'], 'abstract_inverted_index': {'Enterobacteria': [0], 'play': [1], 'important': [2, 49], 'roles': [3], 'in': [4, 121, 165, 178, 186, 202, 230], 'the': [5, 19, 51, 79, 90, 106, 111, 122, 151, 157, 187, 231], 'pathophysiology': [6], 'of': [7, 21, 37, 53, 67, 88, 114, 153, 159, 198, 209, 236], 'small': [8, 29, 80, 91, 141, 223, 232], 'intestinal': [9, 30, 32, 54, 81, 92, 107, 142, 224], 'injuries': [10, 82, 143], 'induced': [11], 'by': [12, 127, 227, 234], 'nonsteroidal': [13], 'anti-inflammatory': [14], 'drugs': [15], '(NSAIDs).': [16], 'We': [17], 'investigated': [18], 'effects': [20], 'rebamipide,': [22, 89], 'a': [23, 42], 'gastrointestinal': [24], 'mucoprotective': [25], 'drug,': [26], 'on': [27], 'indomethacin-induced': [28, 140, 222], 'injuries,': [31, 225], 'microbiota,': [33], 'and': [34, 47, 78, 116, 133, 144, 155, 161, 183], 'expression': [35, 112, 182, 197, 208], 'levels': [36, 113, 185], 'α-defensin': [38, 119, 179, 199, 210, 237], '5,': [39], 'which': [40], 'is': [41, 48], 'Paneth': [43], 'cell-specific': [44], 'antimicrobial': [45], 'peptide': [46], 'for': [50, 75, 118], 'regulation': [52], 'microbiota.': [55], 'Indomethacin': [56, 195], '(10': [57], 'mg/kg)': [58, 72], 'was': [59], 'orally': [60], 'administered': [61], 'to': [62, 96, 104, 191], 'mice': [63, 169], 'after': [64], 'oral': [65, 86], 'administration': [66, 87], 'rebamipide': [68, 149, 174, 206, 220], '(100': [69], 'or': [70, 73], '300': [71], 'vehicle': [74], '1': [76], 'week,': [77], 'were': [83, 94, 125, 171], 'assessed.': [84], 'After': [85], 'contents': [93], 'subjected': [95], 'terminal': [97], 'restriction': [98], 'fragment': [99], 'length': [100], 'polymorphism': [101], '(T-RFLP)': [102], 'analysis': [103, 146], 'assess': [105], 'microbiota': [108, 229], 'composition.': [109], 'Further,': [110], 'mRNA': [115, 181, 201], 'protein': [117, 184], '5': [120, 180, 200, 211], 'ileal': [123, 188, 203], 'tissue': [124, 189], 'determined': [126], 'real-time': [128], 'reverse': [129], 'transcription–polymerase': [130], 'chain': [131], 'reaction': [132], 'western': [134], 'blotting': [135], 'analysis,': [136], 'respectively.': [137], 'Rebamipide': [138], 'inhibited': [139], 'T-RFLP': [145], 'showed': [147, 175], 'that': [148, 164, 170, 219], 'increased': [150], 'percentage': [152, 158], 'Lactobacillales': [154], 'decreased': [156], 'Bacteroides': [160], 'Clostridium': [162], 'than': [163], 'vehicle-treated': [166, 192], 'controls.': [167], 'The': [168], 'treated': [172], 'with': [173], 'an': [176], 'increase': [177], 'compared': [190], 'control': [193], 'mice.': [194], 'reduced': [196], 'tissue,': [204], 'while': [205], 'reversed': [207], 'mRNA.': [212], 'In': [213], 'conclusion,': [214], 'our': [215], 'study': [216], 'results': [217], 'suggest': [218], 'inhibits': [221], 'possibly': [226], 'modulating': [228], 'intestine': [233], 'upregulation': [235], '5.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042880181', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-09-19T12:26:02.471723', 'created_date': '2016-06-24'}