Publication Information

{'id': 'https://openalex.org/W2036973193', 'doi': 'https://doi.org/10.2133/dmpk.20.177', 'title': 'Evaluation of Dextromethorphan Metabolism Using Hepatocytes from CYP2D6 Poor and Extensive Metabolizers', 'display_name': 'Evaluation of Dextromethorphan Metabolism Using Hepatocytes from CYP2D6 Poor and Extensive Metabolizers', 'publication_year': 2005, 'publication_date': '2005-01-01', 'ids': {'openalex': 'https://openalex.org/W2036973193', 'doi': 'https://doi.org/10.2133/dmpk.20.177', 'mag': '2036973193', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15988119'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2133/dmpk.20.177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185835163', 'display_name': 'Drug Metabolism and Pharmacokinetics', 'issn_l': '1347-4367', 'issn': ['1347-4367', '1880-0920'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076494492', 'display_name': 'Tadayuki Takashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tadayuki Takashima', 'raw_affiliation_strings': ['Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035850862', 'display_name': 'Shigeo Murase', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigeo Murase', 'raw_affiliation_strings': ['Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056491345', 'display_name': 'Katsunori Iwasaki', 'orcid': 'https://orcid.org/0000-0002-3808-8904'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuhide Iwasaki', 'raw_affiliation_strings': ['Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100774583', 'display_name': 'Kaoru Shimada', 'orcid': 'https://orcid.org/0000-0002-4747-9595'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kaoru Shimada', 'raw_affiliation_strings': ['Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics Dynamics and Metabolism, Nagoya Laboratories, Pfizer Inc., Aichi, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5056491345'], 'corresponding_institution_ids': ['https://openalex.org/I4210148786'], 'apc_list': {'value': 3580, 'currency': 'USD', 'value_usd': 3580, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.383, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.910003, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '20', 'issue': '3', 'first_page': '177', 'last_page': '182'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9777, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dextrorphan', 'display_name': 'Dextrorphan', 'score': 0.93181014}, {'id': 'https://openalex.org/keywords/glucuronide', 'display_name': 'Glucuronide', 'score': 0.6328502}, {'id': 'https://openalex.org/keywords/drug-metabolism', 'display_name': 'Drug Metabolism', 'score': 0.529492}, {'id': 'https://openalex.org/keywords/metabolic-regulation', 'display_name': 'Metabolic Regulation', 'score': 0.515963}, {'id': 'https://openalex.org/keywords/beagle', 'display_name': 'Beagle', 'score': 0.45016345}, {'id': 'https://openalex.org/keywords/debrisoquine', 'display_name': 'Debrisoquine', 'score': 0.43841535}], 'concepts': [{'id': 'https://openalex.org/C2781245242', 'wikidata': 'https://www.wikidata.org/wiki/Q407781', 'display_name': 'Dextromethorphan', 'level': 2, 'score': 0.97690225}, {'id': 'https://openalex.org/C2779591118', 'wikidata': 'https://www.wikidata.org/wiki/Q659468', 'display_name': 'Dextrorphan', 'level': 3, 'score': 0.93181014}, {'id': 'https://openalex.org/C33664856', 'wikidata': 'https://www.wikidata.org/wiki/Q3271142', 'display_name': 'CYP2D6', 'level': 4, 'score': 0.83354914}, {'id': 'https://openalex.org/C2779186261', 'wikidata': 'https://www.wikidata.org/wiki/Q137786', 'display_name': 'Glucuronide', 'level': 3, 'score': 0.6328502}, {'id': 'https://openalex.org/C89311334', 'wikidata': 'https://www.wikidata.org/wiki/Q1124842', 'display_name': 'Drug metabolism', 'level': 3, 'score': 0.6176732}, {'id': 'https://openalex.org/C109650736', 'wikidata': 'https://www.wikidata.org/wiki/Q424440', 'display_name': 'CYP3A4', 'level': 4, 'score': 0.5899353}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.565523}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.5395415}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5290576}, {'id': 'https://openalex.org/C2779907587', 'wikidata': 'https://www.wikidata.org/wiki/Q14901439', 'display_name': 'Glucuronidation', 'level': 4, 'score': 0.46804807}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.46706754}, {'id': 'https://openalex.org/C2776820430', 'wikidata': 'https://www.wikidata.org/wiki/Q21102', 'display_name': 'Beagle', 'level': 2, 'score': 0.45016345}, {'id': 'https://openalex.org/C2777600422', 'wikidata': 'https://www.wikidata.org/wiki/Q3704421', 'display_name': 'Debrisoquine', 'level': 5, 'score': 0.43841535}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43537584}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42126116}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.40004554}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.36990038}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.3406465}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3190325}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.11933288}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.062966436}], 'mesh': [{'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003915', 'descriptor_name': 'Dextromethorphan', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015925', 'descriptor_name': 'Cryopreservation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065690', 'descriptor_name': 'Cytochrome P-450 CYP2D6 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003915', 'descriptor_name': 'Dextromethorphan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011802', 'descriptor_name': 'Quinidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011802', 'descriptor_name': 'Quinidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2133/dmpk.20.177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185835163', 'display_name': 'Drug Metabolism and Pharmacokinetics', 'issn_l': '1347-4367', 'issn': ['1347-4367', '1880-0920'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15988119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1496043358', 'https://openalex.org/W1934006338', 'https://openalex.org/W1969639825', 'https://openalex.org/W1971559706', 'https://openalex.org/W1979259734', 'https://openalex.org/W1993020095', 'https://openalex.org/W1993047099', 'https://openalex.org/W2002945788', 'https://openalex.org/W2005037385', 'https://openalex.org/W2010606080', 'https://openalex.org/W2023736833', 'https://openalex.org/W2033564508', 'https://openalex.org/W2044002533', 'https://openalex.org/W2053041537', 'https://openalex.org/W2055605433', 'https://openalex.org/W2071332031', 'https://openalex.org/W2072332155', 'https://openalex.org/W2084686194', 'https://openalex.org/W2089085494', 'https://openalex.org/W2089231631', 'https://openalex.org/W2096465105', 'https://openalex.org/W2115111647', 'https://openalex.org/W2133986791', 'https://openalex.org/W2268360283', 'https://openalex.org/W2401633376'], 'related_works': ['https://openalex.org/W3189811395', 'https://openalex.org/W2601342532', 'https://openalex.org/W2508975215', 'https://openalex.org/W2137652189', 'https://openalex.org/W2075704939', 'https://openalex.org/W2042632717', 'https://openalex.org/W2024243546', 'https://openalex.org/W1984782105', 'https://openalex.org/W1980999891', 'https://openalex.org/W1967102127'], 'abstract_inverted_index': {'It': [0], 'is': [1], 'important': [2], 'to': [3], 'estimate': [4], 'the': [5, 17, 22, 34, 37, 45, 70, 82, 100, 115, 118, 121, 127, 139, 146, 154], 'defective': [6], 'metabolism': [7, 38], 'caused': [8], 'by': [9, 78, 107], 'genetic': [10], 'polymorphism': [11], 'of': [12, 24, 28, 36, 53, 56, 74, 104, 120, 129, 143, 163], 'drug': [13, 47], 'metabolizing': [14], 'enzymes': [15], 'before': [16], 'clinical': [18, 71, 112, 161], 'stage.': [19], 'We': [20], 'evaluated': [21], 'utility': [23], 'cryopreserved': [25], 'human': [26], 'hepatocytes': [27, 65, 84, 123, 148, 174], 'CYP2D6': [29, 49, 63, 92, 108, 125, 172, 184], 'poor': [30], 'metabolizer': [31, 94], '(PM)': [32], 'for': [33, 48, 182], 'estimation': [35], 'in': [39, 62, 81, 91, 111, 117, 145, 153, 179], 'PM': [40, 64, 83, 147, 173, 185], 'using': [41], 'dextromethorphan': [42, 68], '(DEX)': [43], 'as': [44, 109], 'probe': [46], 'substrate.': [50], 'The': [51], 'results': [52, 168], 'low': [54], 'formations': [55], 'dextrorphan': [57], '(DXO)': [58], 'and': [59], '3-hydroxymorphinan': [60], '(3-HM)': [61], 'incubated': [66], 'with': [67, 124, 160], 'reflected': [69], 'data.': [72], 'Formation': [73], '3-methoxymorphinan': [75], '(3-MEM)': [76], 'normalized': [77], 'CYP3A4/5': [79], 'activity': [80], 'reached': [85], 'about': [86], '2.8-fold': [87], 'higher': [88], 'than': [89, 151], 'that': [90, 152, 171], 'extensive': [93], '(EM)': [95], 'hepatocytes,': [96, 156], 'which': [97, 157], 'clearly': [98], 'showed': [99], 'compensatory': [101], 'metabolic': [102], 'pathway': [103], 'O-demethylation': [105], 'catalyzed': [106], 'seen': [110], 'study.': [113], 'On': [114], 'contrary,': [116], 'condition': [119], 'EM': [122, 155], 'inhibitors,': [126], 'enhancement': [128], '3-MEM': [130], 'formation': [131, 141], 'was': [132, 149, 158], 'not': [133], 'observed.': [134], 'In': [135], 'phase': [136], 'II': [137], 'reaction,': [138], 'glucuronide': [140], 'rate': [142], 'DXO': [144], 'lower': [150], 'consistent': [159], 'data': [162], 'DXO-glucuronide': [164], '(DXO-glu)': [165], 'concentration.': [166], 'These': [167], 'would': [169], 'suggest': [170], 'could': [175], 'be': [176], 'a': [177], 'good': [178], 'vitro': [180], 'tool': [181], 'estimating': [183], 'pharmacokinetics.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2036973193', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-25T17:35:18.073057', 'created_date': '2016-06-24'}