Title: Response to X-irradiation of mouse embryonic lung cultured in vitro
Abstract: The radiation response of mouse embryonic lung rudiments cultured in vitro was studied using as a criterion for a quantitative evaluation of the radiation effect the relative size increment of the epithelial tree as a function of dose. It was shown that the rate of growth of the bronchial tree as a whole appears to be highly radiation-sensitive and that the radiation-induced growth depression effect is dependent on X-ray exposure dose. The dose-effect curves show that an attempt to overcome the radiation growth inhibiting effect is made after 30 hr from irradiation when exposure doses are of 175 R or smaller. A cytological basis for the interpretation of this radiation effect is proposed as a consequence of a selective depletion of the mesenchymal cell population.
Publication Year: 1966
Publication Date: 1966-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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