Publication Information

{'id': 'https://openalex.org/W2013402390', 'doi': 'https://doi.org/10.1093/infdis/167.5.1224', 'title': 'In Vivo Development of Teicoplanin Resistance in a VanB Enterococcus faecium Isolate', 'display_name': 'In Vivo Development of Teicoplanin Resistance in a VanB Enterococcus faecium Isolate', 'publication_year': 1993, 'publication_date': '1993-05-01', 'ids': {'openalex': 'https://openalex.org/W2013402390', 'doi': 'https://doi.org/10.1093/infdis/167.5.1224', 'mag': '2013402390', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8486959'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/infdis/167.5.1224', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/167/5/1224/2461340/167-5-1224.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jid/article-pdf/167/5/1224/2461340/167-5-1224.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056420672', 'display_name': 'Mary K. Hayden', 'orcid': 'https://orcid.org/0000-0002-4603-8501'}, 'institutions': [{'id': 'https://openalex.org/I2800861319', 'display_name': 'Texas Health Dallas', 'ror': 'https://ror.org/05k07p323', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800861319', 'https://openalex.org/I4210163017', 'https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1285301757', 'display_name': 'Rush University Medical Center', 'ror': 'https://ror.org/01j7c0b24', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285301757']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. K. Hayden', 'raw_affiliation_strings': ["Section of Infectious Diseases, Rush-Presbyterian-St. Luke's Medcal Center, Chicago, IL 60612."], 'affiliations': [{'raw_affiliation_string': "Section of Infectious Diseases, Rush-Presbyterian-St. Luke's Medcal Center, Chicago, IL 60612.", 'institution_ids': ['https://openalex.org/I2800861319', 'https://openalex.org/I1285301757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035181444', 'display_name': 'Gordon M. Trenholme', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G. M. Trenholme', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034303304', 'display_name': 'J. E. Schultz', 'orcid': 'https://orcid.org/0000-0001-9174-3528'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J. E. Schultz', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109135830', 'display_name': 'D.F. Sahm', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D. F. Sahm', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4320, 'currency': 'USD', 'value_usd': 4320, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.843, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 171, 'citation_normalized_percentile': {'value': 0.978882, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '167', 'issue': '5', 'first_page': '1224', 'last_page': '1227'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/teicoplanin', 'display_name': 'Teicoplanin', 'score': 0.93257606}, {'id': 'https://openalex.org/keywords/enterococcus-faecium', 'display_name': 'Enterococcus faecium', 'score': 0.7987158}], 'concepts': [{'id': 'https://openalex.org/C2776703206', 'wikidata': 'https://www.wikidata.org/wiki/Q2731762', 'display_name': 'Teicoplanin', 'level': 5, 'score': 0.93257606}, {'id': 'https://openalex.org/C2777677444', 'wikidata': 'https://www.wikidata.org/wiki/Q140010', 'display_name': 'Enterococcus faecium', 'level': 3, 'score': 0.7987158}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7643813}, {'id': 'https://openalex.org/C2780585763', 'wikidata': 'https://www.wikidata.org/wiki/Q517258', 'display_name': 'Enterococcus', 'level': 3, 'score': 0.66439974}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.61429006}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5158719}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.42196256}, {'id': 'https://openalex.org/C2778980435', 'wikidata': 'https://www.wikidata.org/wiki/Q424027', 'display_name': 'Vancomycin', 'level': 4, 'score': 0.28613925}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.27693588}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.17614508}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.090997905}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06910893}], 'mesh': [{'descriptor_ui': 'D016984', 'descriptor_name': 'Enterococcus faecium', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016908', 'descriptor_name': 'Gram-Positive Bacterial Infections', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D017334', 'descriptor_name': 'Teicoplanin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016521', 'descriptor_name': 'Electrophoresis, Gel, Pulsed-Field', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016984', 'descriptor_name': 'Enterococcus faecium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016984', 'descriptor_name': 'Enterococcus faecium', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016908', 'descriptor_name': 'Gram-Positive Bacterial Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016908', 'descriptor_name': 'Gram-Positive Bacterial Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017334', 'descriptor_name': 'Teicoplanin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/infdis/167.5.1224', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/167/5/1224/2461340/167-5-1224.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8486959', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/infdis/167.5.1224', 'pdf_url': 'https://academic.oup.com/jid/article-pdf/167/5/1224/2461340/167-5-1224.pdf', 'source': {'id': 'https://openalex.org/S54542293', 'display_name': 'The Journal of Infectious Diseases', 'issn_l': '0022-1899', 'issn': ['0022-1899', '1537-6613'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.47, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1581962345', 'https://openalex.org/W1862053853', 'https://openalex.org/W1904634031', 'https://openalex.org/W1928483520', 'https://openalex.org/W1953580681', 'https://openalex.org/W1985725647', 'https://openalex.org/W1989870283', 'https://openalex.org/W1999006894', 'https://openalex.org/W2058215092', 'https://openalex.org/W2074092417', 'https://openalex.org/W2076067310', 'https://openalex.org/W2085676950', 'https://openalex.org/W2111027368'], 'related_works': ['https://openalex.org/W4388214266', 'https://openalex.org/W3037538436', 'https://openalex.org/W2893946236', 'https://openalex.org/W2412226067', 'https://openalex.org/W2392063640', 'https://openalex.org/W2370281319', 'https://openalex.org/W2350174808', 'https://openalex.org/W2345752776', 'https://openalex.org/W2146775196', 'https://openalex.org/W1986215468'], 'abstract_inverted_index': {'Acquired': [0], 'vancomycin': [1, 91], 'resistance': [2, 14, 28, 92], 'in': [3, 23, 29], 'enterococci': [4], 'may': [5], 'be': [6, 84], 'associated': [7], 'with': [8, 101, 114], 'teicoplanin': [9, 13, 27, 57, 141], 'susceptibility': [10], '(VanB)': [11], 'or': [12], '(VanA).': [15], 'This': [16], 'paper': [17], 'characterizes': [18], 'the': [19, 59, 71, 81, 137], 'first': [20, 60], 'instance': [21], 'of': [22, 26, 34, 56, 75, 85, 90, 118, 128, 140, 144], 'vivo': [24], 'emergence': [25], 'an': [30], 'Enterococcus': [31], 'faecium': [32, 43], 'strain': [33], 'VanB': [35], 'phenotype.': [36], 'Vancomvcin-': [37], 'resistant': [38, 105], '(MIC.': [39], '2563512': [40], 'µg/mL)': [41], 'E.': [42], 'was': [44, 63, 67, 93], 'isolated': [45], 'intermittently': [46], 'from': [47, 121], 'a': [48, 108, 122, 129], "patient's": [49], 'blood': [50], 'over': [51], '4': [52], 'months.': [53], 'The': [54], 'MIC': [55], 'for': [58, 70, 142], '5': [61], 'isolates': [62, 82], '1.0': [64], 'µ/mL;': [65], 'it': [66], '64': [68], 'µg/mL': [69], 'final': [72], '2.': [73], 'Analysis': [74], 'plasmid': [76], 'and': [77, 104], 'chromosomal': [78], 'DNA': [79, 98], 'revealed': [80, 125], 'to': [83, 112], 'clonal': [86], 'origin.': [87], 'Conjugal': [88], 'transfer': [89], 'not': [94], 'obtained.': [95], 'A': [96], 'vanB': [97], 'probe': [99, 110], 'hybridized': [100], 'both': [102], 'teicoplanin-susceptible': [103], 'isolates,': [106], 'but': [107], 'vanA': [109], 'failed': [111], 'hybridize': [113], 'any': [115], 'isolate.': [116], 'SDS-PAGE': [117], 'membrane': [119], 'proteins': [120], 'teicoplanin-resistant': [123], 'isolate': [124], 'constitutive': [126], 'production': [127], 'normally': [130], 'inducible': [131], '41-kDa': [132], 'protein.': [133], 'These': [134], 'findings': [135], 'challenge': [136], 'ultimate': [138], 'utility': [139], 'treatment': [143], 'infections': [145], 'caused': [146], 'by': [147], 'vancomycin-resistant': [148], 'enterococci.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013402390', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-12T18:55:42.897158', 'created_date': '2016-06-24'}