Publication Information

{'id': 'https://openalex.org/W2012191233', 'doi': 'https://doi.org/10.1080/10715769900301161', 'title': 'Endogenous nitric oxide synthesis: Biological functions and pathophysiology', 'display_name': 'Endogenous nitric oxide synthesis: Biological functions and pathophysiology', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W2012191233', 'doi': 'https://doi.org/10.1080/10715769900301161', 'mag': '2012191233', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10630682'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10715769900301161', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23349031', 'display_name': 'Free Radical Research', 'issn_l': '1029-2470', 'issn': ['1029-2470', '1071-5762'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109042512', 'display_name': 'David S. Bredt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'David S. Bredt', 'raw_affiliation_strings': ['Department of Physiology, University of California at San Francisco School of Medicine 94143-0444, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, University of California at San Francisco School of Medicine 94143-0444, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5109042512'], 'corresponding_institution_ids': ['https://openalex.org/I180670191'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.667, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 796, 'citation_normalized_percentile': {'value': 0.888092, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '577', 'last_page': '596'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endothelial-nos', 'display_name': 'Endothelial NOS', 'score': 0.62442994}], 'concepts': [{'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.6860027}, {'id': 'https://openalex.org/C2779698670', 'wikidata': 'https://www.wikidata.org/wiki/Q408853', 'display_name': 'Endothelial NOS', 'level': 5, 'score': 0.62442994}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.58598965}, {'id': 'https://openalex.org/C22885893', 'wikidata': 'https://www.wikidata.org/wiki/Q4862743', 'display_name': 'Cholinergic', 'level': 2, 'score': 0.5602463}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49288678}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.46571043}, {'id': 'https://openalex.org/C2776219046', 'wikidata': 'https://www.wikidata.org/wiki/Q162657', 'display_name': 'Neurotransmitter', 'level': 3, 'score': 0.43115258}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42309463}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42123303}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.41625845}, {'id': 'https://openalex.org/C2778326061', 'wikidata': 'https://www.wikidata.org/wiki/Q1761022', 'display_name': 'Enos', 'level': 4, 'score': 0.3836677}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.35050625}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34437603}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.30256897}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12840873}], 'mesh': [{'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10715769900301161', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23349031', 'display_name': 'Free Radical Research', 'issn_l': '1029-2470', 'issn': ['1029-2470', '1071-5762'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10630682', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 169, 'referenced_works': ['https://openalex.org/W133907179', 'https://openalex.org/W1483990664', 'https://openalex.org/W1487416252', 'https://openalex.org/W1496457337', 'https://openalex.org/W1511098597', 'https://openalex.org/W1511156825', 'https://openalex.org/W1519096444', 'https://openalex.org/W1541963905', 'https://openalex.org/W1544473077', 'https://openalex.org/W1580354352', 'https://openalex.org/W1594268419', 'https://openalex.org/W1605080122', 'https://openalex.org/W1635837931', 'https://openalex.org/W179619917', 'https://openalex.org/W1821918060', 'https://openalex.org/W1907994445', 'https://openalex.org/W1908877967', 'https://openalex.org/W1926494419', 'https://openalex.org/W1929009802', 'https://openalex.org/W1943358986', 'https://openalex.org/W1964671322', 'https://openalex.org/W1965077361', 'https://openalex.org/W1965341406', 'https://openalex.org/W1965948569', 'https://openalex.org/W1966322594', 'https://openalex.org/W1969725407', 'https://openalex.org/W1970974990', 'https://openalex.org/W1971005608', 'https://openalex.org/W1974049989', 'https://openalex.org/W1975941571', 'https://openalex.org/W1975982125', 'https://openalex.org/W1977394169', 'https://openalex.org/W1978897412', 'https://openalex.org/W1979521526', 'https://openalex.org/W1981046160', 'https://openalex.org/W1983792555', 'https://openalex.org/W1984623813', 'https://openalex.org/W1984997174', 'https://openalex.org/W1986359263', 'https://openalex.org/W1986435945', 'https://openalex.org/W1986967983', 'https://openalex.org/W1988251156', 'https://openalex.org/W1988726352', 'https://openalex.org/W1988951836', 'https://openalex.org/W1990586673', 'https://openalex.org/W1991611562', 'https://openalex.org/W1993113186', 'https://openalex.org/W1995330034', 'https://openalex.org/W2000075945', 'https://openalex.org/W2000220983', 'https://openalex.org/W2001548627', 'https://openalex.org/W2005208897', 'https://openalex.org/W2006705030', 'https://openalex.org/W2007737411', 'https://openalex.org/W2009013636', 'https://openalex.org/W2010469212', 'https://openalex.org/W2010568219', 'https://openalex.org/W2011857875', 'https://openalex.org/W2012038403', 'https://openalex.org/W2013063789', 'https://openalex.org/W2016470389', 'https://openalex.org/W2016687652', 'https://openalex.org/W2018205667', 'https://openalex.org/W2019613587', 'https://openalex.org/W2020045182', 'https://openalex.org/W2020739416', 'https://openalex.org/W2022699060', 'https://openalex.org/W2023170094', 'https://openalex.org/W2024275247', 'https://openalex.org/W2024862570', 'https://openalex.org/W2025185754', 'https://openalex.org/W2026021727', 'https://openalex.org/W2026833472', 'https://openalex.org/W2030529658', 'https://openalex.org/W2034307263', 'https://openalex.org/W2035752728', 'https://openalex.org/W2037854429', 'https://openalex.org/W2038978204', 'https://openalex.org/W2042054187', 'https://openalex.org/W2042716629', 'https://openalex.org/W2042782418', 'https://openalex.org/W2044597829', 'https://openalex.org/W2044869734', 'https://openalex.org/W2044918962', 'https://openalex.org/W2045138089', 'https://openalex.org/W2045639174', 'https://openalex.org/W2045980084', 'https://openalex.org/W2046663117', 'https://openalex.org/W2047035909', 'https://openalex.org/W2048635427', 'https://openalex.org/W2048756826', 'https://openalex.org/W2049161948', 'https://openalex.org/W2049472065', 'https://openalex.org/W2049786479', 'https://openalex.org/W2050255961', 'https://openalex.org/W2051031104', 'https://openalex.org/W2051235004', 'https://openalex.org/W2051890182', 'https://openalex.org/W2055950603', 'https://openalex.org/W2056147576', 'https://openalex.org/W2057025197', 'https://openalex.org/W2057850915', 'https://openalex.org/W2059155059', 'https://openalex.org/W2059379142', 'https://openalex.org/W2059640915', 'https://openalex.org/W2060243949', 'https://openalex.org/W2063764790', 'https://openalex.org/W2064273870', 'https://openalex.org/W2065182000', 'https://openalex.org/W2066168019', 'https://openalex.org/W2067286448', 'https://openalex.org/W2068742980', 'https://openalex.org/W2070870600', 'https://openalex.org/W2071624888', 'https://openalex.org/W2072240979', 'https://openalex.org/W2074187719', 'https://openalex.org/W2077798575', 'https://openalex.org/W2079625010', 'https://openalex.org/W2081228674', 'https://openalex.org/W2083221955', 'https://openalex.org/W2085327871', 'https://openalex.org/W2086652686', 'https://openalex.org/W2086823174', 'https://openalex.org/W2091129183', 'https://openalex.org/W2092145002', 'https://openalex.org/W2092620816', 'https://openalex.org/W2092928881', 'https://openalex.org/W2094931296', 'https://openalex.org/W2095384133', 'https://openalex.org/W2100164481', 'https://openalex.org/W2104380573', 'https://openalex.org/W2107429652', 'https://openalex.org/W2113505793', 'https://openalex.org/W2120533372', 'https://openalex.org/W2128727709', 'https://openalex.org/W2132666492', 'https://openalex.org/W2140936548', 'https://openalex.org/W2142575579', 'https://openalex.org/W2144744298', 'https://openalex.org/W2150656456', 'https://openalex.org/W2153889396', 'https://openalex.org/W2157281419', 'https://openalex.org/W2162455056', 'https://openalex.org/W2169182236', 'https://openalex.org/W2169280213', 'https://openalex.org/W2173833672', 'https://openalex.org/W2214599147', 'https://openalex.org/W2277288131', 'https://openalex.org/W2283802759', 'https://openalex.org/W22857079', 'https://openalex.org/W2304131176', 'https://openalex.org/W2324927661', 'https://openalex.org/W2329765567', 'https://openalex.org/W2398807704', 'https://openalex.org/W2402399220', 'https://openalex.org/W2406062456', 'https://openalex.org/W2412298660', 'https://openalex.org/W2412377394', 'https://openalex.org/W2469424319', 'https://openalex.org/W263340198', 'https://openalex.org/W4205205604', 'https://openalex.org/W4235019056', 'https://openalex.org/W4239545644', 'https://openalex.org/W4242134579', 'https://openalex.org/W4250156130', 'https://openalex.org/W4253873282', 'https://openalex.org/W4255564469', 'https://openalex.org/W4285719527', 'https://openalex.org/W46142867'], 'related_works': ['https://openalex.org/W3150803062', 'https://openalex.org/W3030505798', 'https://openalex.org/W3026529892', 'https://openalex.org/W2284947444', 'https://openalex.org/W2249728733', 'https://openalex.org/W2139541900', 'https://openalex.org/W2126050374', 'https://openalex.org/W2074042972', 'https://openalex.org/W2066360730', 'https://openalex.org/W2019650760'], 'abstract_inverted_index': {'Modern': [0], 'molecular': [1], 'biology': [2], 'has': [3], 'revealed': [4], 'vast': [5], 'numbers': [6], 'of': [7, 30, 58, 102, 114, 135, 142, 147, 191, 206, 242, 255, 285, 291, 318, 331, 340, 349, 354, 370, 405, 411, 426, 471], 'large': [8], 'and': [9, 12, 36, 72, 125, 198, 202, 226, 237, 244, 275, 310, 328, 366, 385, 418, 436, 445, 477], 'complex': [10, 306], 'proteins': [11], 'genes': [13], 'that': [14, 27], 'regulate': [15, 297], 'body': [16, 151], 'function.': [17], 'By': [18], 'contrast,': [19], 'discoveries': [20], 'over': [21], 'the': [22, 150, 165, 195, 199, 230, 282, 294, 304, 316, 347, 371, 469], 'past': [23], 'ten': [24], 'years': [25], 'indicate': [26], 'crucial': [28], 'features': [29], 'neuronal': [31, 401], 'communication,': [32], 'blood': [33], 'vessel': [34], 'modulation': [35], 'immune': [37], 'response': [38], 'are': [39, 75, 82, 93, 152, 376], 'mediated': [40, 94, 110, 358], 'by': [41, 55, 84, 95, 111, 359, 363, 367, 380, 440, 446], 'a': [42, 56, 96, 132, 160, 174, 184, 213, 235, 253, 262, 399, 429, 465], 'remarkably': [43], 'simple': [44], 'chemical,': [45], 'nitric': [46], 'oxide': [47], '(NO).': [48], 'Endogenous': [49], 'NO': [50, 63, 92, 138, 148, 157, 169, 171, 232, 248, 259, 270, 292, 311, 321, 332, 341, 350, 392, 395, 406, 432, 461], 'is': [51, 109, 343, 357, 433], 'generated': [52], 'from': [53, 68], 'arginine': [54, 136], 'family': [57], 'three': [59, 117], 'distinct': [60], 'calmodulin-': [61], 'dependent': [62], 'synthase': [64], '(NOS)': [65], 'enzymes.': [66], 'NOS': [67, 99, 118, 207], 'endothelial': [69], 'cells': [70], '(eNOS)': [71], 'neurons': [73], '(nNOS)': [74], 'both': [76], 'constitutively': [77], 'expressed': [78], 'enzymes,': [79], 'whose': [80], 'activities': [81], 'stimulated': [83], 'increases': [85], 'in': [86, 154, 188, 194, 209, 216, 265, 303, 307, 315, 323, 382, 390, 423, 468], 'intracellular': [87], 'calcium.': [88], 'Immune': [89], 'functions': [90, 158, 170, 172, 233, 397], 'for': [91], 'calcium-independent': [97], 'inducible': [98], '(iNOS).': [100], 'Expression': [101], 'iNOS': [103], 'protein': [104, 301, 374], 'requires': [105, 326], 'transcriptional': [106], 'activation,': [107], 'which': [108, 288], 'specific': [112, 334], 'combinations': [113], 'cytokines.': [115], 'All': [116], 'use': [119], 'NADPH': [120], 'as': [121, 159, 173, 234, 252, 398], 'an': [122, 452], 'electron': [123], 'donor': [124], 'employ': [126], 'five': [127], 'enzyme': [128, 361], 'cofactors': [129], 'to': [130, 137, 239, 293, 296, 333, 450, 463], 'catalyze': [131], 'five-electron': [133], 'oxidation': [134], 'with': [139, 415, 448], 'stoichiometric': [140], 'formation': [141], 'citrulline.': [143], 'The': [144], 'highest': [145], 'levels': [146, 375], 'throughout': [149], 'found': [153], 'neurons,': [155], 'where': [156], 'unique': [161], 'messenger': [162], 'molecule.': [163], 'In': [164, 229], 'autonomic': [166, 210], 'nervous': [167], 'system': [168], 'major': [175, 214, 263, 466], 'non-adrenergic': [176], 'non-cholinergic': [177], '(NANC)': [178], 'neurotransmitter.': [179], 'This': [180, 337], 'NANC': [181], 'pathway': [182], 'plays': [183, 212, 261], 'particularly': [185], 'important': [186], 'role': [187, 215, 264, 467], 'producing': [189], 'relaxation': [190], 'smooth': [192, 256], 'muscle': [193, 257, 273, 287, 298, 309], 'cerebral': [196, 416], 'circulation': [197], 'gastrointestinal,': [200], 'urogenital': [201], 'respiratory': [203], 'tracts.': [204], 'Dysregulation': [205], 'activity': [208, 356], 'nerves': [211], 'diverse': [217], 'pathophysiological': [218], 'conditions': [219], 'including': [220], 'migraine': [221], 'headache,': [222], 'hypertrophic': [223], 'pyloric': [224], 'stenosis': [225], 'male': [227], 'impotence.': [228], 'brain,': [231], 'neuromodulator': [236], 'appears': [238, 462], 'mediate': [240], 'aspects': [241], 'learning': [243], 'memory.': [245], 'Although': [246], 'endogenous': [247], 'was': [249], 'originally': [250], 'appreciated': [251], 'mediator': [254], 'relaxation,': [258], 'also': [260, 377], 'skeletal': [266, 272, 286, 308], 'muscle.': [267], 'Physiologically': [268], 'muscle-derived': [269], 'regulates': [271], 'contractility': [274], 'exercise-induced': [276], 'glucose': [277], 'uptake.': [278], 'nNOS': [279, 300, 355, 373], 'occurs': [280, 302], 'at': [281, 346], 'plasma': [283], 'membrane': [284], 'facilitates': [289], 'diffusion': [290], 'vasculature': [295], 'perfusion.': [299], 'dystrophin': [305], 'may': [312], 'therefore': [313], 'participate': [314], 'pathophysiology': [317, 470], 'muscular': [319], 'dystrophy.': [320], 'signalling': [322, 342], 'excitable': [324], 'tissues': [325], 'rapid': [327], 'controlled': [329], 'delivery': [330], 'cellular': [335, 438], 'targets.': [336], 'tight': [338], 'control': [339, 353], 'largely': [344], 'regulated': [345, 379], 'level': [348], 'biosynthesis.': [351], 'Acute': [352], 'allosteric': [360], 'regulation,': [362], 'posttranslational': [364], 'modification': [365], 'subcellular': [368], 'targeting': [369], 'enzyme.': [372], 'dynamically': [378], 'changes': [381, 389], 'gene': [383], 'transcription,': [384], 'this': [386], 'affords': [387], 'long-lasting': [388], 'tissue': [391], 'levels.': [393], 'While': [394], 'normally': [396], 'physiological': [400], 'mediator,': [402], 'excess': [403], 'production': [404], 'mediates': [407, 437], 'brain': [408], 'injury.': [409], 'Overactivation': [410], 'glutamate': [412], 'receptors': [413], 'associated': [414], 'ischemia': [417], 'other': [419], 'excitotoxic': [420], 'processes': [421], 'results': [422], 'massive': [424], 'release': [425], 'NO.': [427], 'As': [428], 'free': [430], 'radical,': [431], 'inherently': [434], 'reactive': [435], 'toxicity': [439], 'damaging': [441], 'critical': [442], 'metabolic': [443], 'enzymes': [444], 'reacting': [447], 'superoxide': [449], 'form': [451], 'even': [453], 'more': [454], 'potent': [455], 'oxidant,': [456], 'peroxynitrite.': [457], 'Through': [458], 'these': [459], 'mechanisms,': [460], 'play': [464], 'stroke,': [472], "Parkinson's": [473], 'disease,': [474], "Huntington's": [475], 'disease': [476], 'amyotrophic': [478], 'lateral': [479], 'sclerosis.': [480]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012191233', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 24}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 27}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 31}, {'year': 2014, 'cited_by_count': 33}, {'year': 2013, 'cited_by_count': 30}, {'year': 2012, 'cited_by_count': 38}], 'updated_date': '2024-12-11T11:53:50.354944', 'created_date': '2016-06-24'}