Title: Nucleic acid base complexes with thiotepa as revealed by field ionization mass spectrometry
Abstract: Biomedical & Environmental Mass SpectrometryVolume 13, Issue 4 p. 167-170 Article Nucleic acid base complexes with thiotepa as revealed by field ionization mass spectrometry L. F. Sukhodub, L. F. Sukhodub Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorV. S. Shelkovsky, V. S. Shelkovsky Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorM. V. Kosevich, M. V. Kosevich Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorT. L. Pyatigorskaya, T. L. Pyatigorskaya Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorO. Yu. Zhilkova, O. Yu. Zhilkova Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this author L. F. Sukhodub, L. F. Sukhodub Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorV. S. Shelkovsky, V. S. Shelkovsky Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorM. V. Kosevich, M. V. Kosevich Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorT. L. Pyatigorskaya, T. L. Pyatigorskaya Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this authorO. Yu. Zhilkova, O. Yu. Zhilkova Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSRSearch for more papers by this author First published: April 1986 https://doi.org/10.1002/bms.1200130403Citations: 12 Institute for Low Temperature Physics and Engineering, Ukrainian SSR Academy of Sciences, 47 Lenin Avenue, Kharkov 310164, USSR AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The interaction of nucleic acid bases with the alkylating antitumour drug thiotepa has been studied by field ionization mass spectrometry. The possibility of interaction between all four DNA bases and thiotepa in neutral aqueous solutions was demonstrated. The analysis of the data for different methylated bases made it possible to elucidate some sites of alkylation—N(1)(Cyt), N(3)(Thy), N(9)(Ade)—which are compared with data on other alkylating agents available from the literature. References 1 N. P. Dubinin and E. G. Saprikina, Dokl. Akad. Nauk SSSR 158, 956 (1964). 2 K. Hemminki, S. Kallama and K. Falck, Acta Pharmacol. Toxicol. 53, 421 (1983). 3 T. L. Pyatigorskaya, O. Yu. Zhilkova, N. M. Arkhangelova, V. S. Shelkovsky and L. F. Sukhodub, Himiko-farmatsevticheski Zh. 28, 343 (1984). 4 T. L. Pyatigorskaya, O. Yu. Zhilkova, V. S. Shelkovsky, M. V. Kosevich, A. I. Grizodub, V. N. Troyan and L. F. Sukhodub, Himiko-farmatsevticheski Zh. 29, 1235 (1985). 5 I. K. Yanson, A. B. Teplitsky and L. F. Sukhodub, Biopolymers 18, 1149 (1979). 6 B. Singer, in Progress in Nucleic Acid Research and Molecular Biology, ed. by W. E. Cohen, Vol. 15, p. 219, Academic Press, New York (1975). 7 C. C. Price, G. M. Gaucher, P. Koneru, R. Shibakawa, J. R. Sowa and M. Yanaguchi, Biochim. Biophys. Acta 166, 327 (1968). 8 S. Peng, A. Padva and P. R. Liberton, Proc. Natl. Acad. Sci. USA 73, 2966 (1976). 9 P. D. Lawley and P. Brookes, Nature (London) 192, 1081 (1961). 10 A. Pullman and A. M. Armbruster, Theoret. Chim. Acta 45, 249 (1977). 11 J. E. Del Bene, J. Phys. Chem. 87, 367 (1983). 12 B. N. Sidorov, N. N. Sokolov and V. S. Andreev, Genetica 2, 124 (1966). Citing Literature Volume13, Issue4April 1986Pages 167-170 ReferencesRelatedInformation
Publication Year: 1986
Publication Date: 1986-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 18
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