Title: Respiratory response to hypoxia with hypocapnia or normocapnia and to CO2 in hypothermic dogs
Abstract: The effects of hypothermia on the ventilatory response to hypoxia and hypercapnia were studied in anesthetized dogs by a rebreathing method. The ventilatory response to hypoxia was determined at two levels of PACO2: with CO2 kept at control level and with CO2 allowed to decrease. Experiments in hypothermia were conducted at about 10 °C below normothermia (mean body temperature: 27.9 °C), a temperature selected to give an air-breathing ventilation equal to that found in normothermia. At this temperature, gentle shivering occurred. The sensitivity to CO2 without hypoxia was remarkably depressed in hypothermia. The ventilatory response to hypoxia with CO2 kept at control level was also depressed and essentially the same as that with CO2 allowed to decrease during normothermia or hypothermia. It is concluded that 1) the sensitivity of the central chemoreceptors to CO2 is mainly depressed during hypothermia; 2) hypothermia does not have much effect on the function of the peripheral chemoreceptors.
Publication Year: 1969
Publication Date: 1969-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 22
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