Publication Information

{'id': 'https://openalex.org/W1999220169', 'doi': 'https://doi.org/10.1002/jez.b.21302', 'title': 'Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells', 'display_name': 'Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells', 'publication_year': 2009, 'publication_date': '2009-06-23', 'ids': {'openalex': 'https://openalex.org/W1999220169', 'doi': 'https://doi.org/10.1002/jez.b.21302', 'mag': '1999220169', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19551764'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jez.b.21302', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222104', 'display_name': 'Journal of Experimental Zoology Part B Molecular and Developmental Evolution', 'issn_l': '1552-5007', 'issn': ['1552-5007', '1552-5015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101585453', 'display_name': 'Yulin Xu', 'orcid': 'https://orcid.org/0000-0002-2736-6075'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yulin Xu', 'raw_affiliation_strings': ['Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China.', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031979262', 'display_name': 'Minli Yu', 'orcid': 'https://orcid.org/0000-0002-9902-6985'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Minli Yu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068845676', 'display_name': 'Fabai Wu', 'orcid': 'https://orcid.org/0000-0001-5812-5621'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fabai Wu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024278695', 'display_name': 'Jianguo Sun', 'orcid': 'https://orcid.org/0000-0003-4417-7644'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jianguo Sun', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022169566', 'display_name': 'Chris Wood', 'orcid': 'https://orcid.org/0000-0002-5517-9496'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chris Wood', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053530353', 'display_name': 'Masa‐aki Hattori', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masa-Aki Hattori', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101748821', 'display_name': 'Jinfu Wang', 'orcid': 'https://orcid.org/0000-0002-8476-1901'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jinfu Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082264501', 'display_name': 'Yongmei Xi', 'orcid': 'https://orcid.org/0000-0001-7374-2564'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yongmei Xi', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3140, 'currency': 'USD', 'value_usd': 3140, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.2, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.645948, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '312B', 'issue': '8', 'first_page': '872', 'last_page': '884'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12929', 'display_name': 'Transgenic Animal Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12929', 'display_name': 'Transgenic Animal Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10937', 'display_name': 'Cellular Senescence and Aging-Related Diseases', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10753', 'display_name': 'Microplastic Pollution in Marine and Terrestrial Environments', 'score': 0.98, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ectopic-expression', 'display_name': 'Ectopic expression', 'score': 0.58981186}, {'id': 'https://openalex.org/keywords/telomerase', 'display_name': 'Telomerase', 'score': 0.508669}], 'concepts': [{'id': 'https://openalex.org/C125593758', 'wikidata': 'https://www.wikidata.org/wiki/Q15315135', 'display_name': 'Telomerase reverse transcriptase', 'level': 4, 'score': 0.9582199}, {'id': 'https://openalex.org/C94581717', 'wikidata': 'https://www.wikidata.org/wiki/Q331839', 'display_name': 'Telomerase', 'level': 3, 'score': 0.91828585}, {'id': 'https://openalex.org/C177336024', 'wikidata': 'https://www.wikidata.org/wiki/Q14872779', 'display_name': 'Telomere', 'level': 3, 'score': 0.6251713}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6134272}, {'id': 'https://openalex.org/C97037327', 'wikidata': 'https://www.wikidata.org/wiki/Q5334291', 'display_name': 'Ectopic expression', 'level': 3, 'score': 0.58981186}, {'id': 'https://openalex.org/C2777074287', 'wikidata': 'https://www.wikidata.org/wiki/Q1473931', 'display_name': 'Keratinocyte', 'level': 3, 'score': 0.56107765}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.54922605}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.48500177}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.4167649}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.40309983}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39458227}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37106118}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09435731}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.085403115}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08428353}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005241', 'descriptor_name': 'Feathers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015603', 'descriptor_name': 'Keratinocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002461', 'descriptor_name': 'Cell Line, Transformed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017403', 'descriptor_name': 'In Situ Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015603', 'descriptor_name': 'Keratinocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015603', 'descriptor_name': 'Keratinocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jez.b.21302', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222104', 'display_name': 'Journal of Experimental Zoology Part B Molecular and Developmental Evolution', 'issn_l': '1552-5007', 'issn': ['1552-5007', '1552-5015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19551764', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1543500873', 'https://openalex.org/W1632349675', 'https://openalex.org/W1942686027', 'https://openalex.org/W1968325292', 'https://openalex.org/W1970291858', 'https://openalex.org/W1977279007', 'https://openalex.org/W1984374449', 'https://openalex.org/W1985623818', 'https://openalex.org/W1985880165', 'https://openalex.org/W1995205742', 'https://openalex.org/W2003409493', 'https://openalex.org/W2004247546', 'https://openalex.org/W2004249786', 'https://openalex.org/W2004745607', 'https://openalex.org/W2010019056', 'https://openalex.org/W2021336778', 'https://openalex.org/W2027240315', 'https://openalex.org/W2033011717', 'https://openalex.org/W2035423713', 'https://openalex.org/W2038507177', 'https://openalex.org/W2042377388', 'https://openalex.org/W2053620236', 'https://openalex.org/W2059295946', 'https://openalex.org/W2062628055', 'https://openalex.org/W2068409711', 'https://openalex.org/W2070153141', 'https://openalex.org/W2076277214', 'https://openalex.org/W2079378073', 'https://openalex.org/W2085786821', 'https://openalex.org/W2104908670', 'https://openalex.org/W2105513775', 'https://openalex.org/W2108482850', 'https://openalex.org/W2110419228', 'https://openalex.org/W2112698595', 'https://openalex.org/W2119999468', 'https://openalex.org/W2130815575', 'https://openalex.org/W2136017046', 'https://openalex.org/W2154938844', 'https://openalex.org/W2157784982', 'https://openalex.org/W2161861717', 'https://openalex.org/W2167646349', 'https://openalex.org/W2393490659', 'https://openalex.org/W3028308266'], 'related_works': ['https://openalex.org/W60632522', 'https://openalex.org/W4241189537', 'https://openalex.org/W2417511905', 'https://openalex.org/W2400859286', 'https://openalex.org/W2127443475', 'https://openalex.org/W2103156000', 'https://openalex.org/W2090447055', 'https://openalex.org/W2073119209', 'https://openalex.org/W2050296416', 'https://openalex.org/W2005903392'], 'abstract_inverted_index': {'Abstract': [0], 'Normal': [1], 'somatic': [2], 'cells': [3, 60], 'possess': [4], 'a': [5, 16, 199, 212], 'finite': [6], 'life': [7], 'span': [8], 'owing': [9], 'to': [10], 'replicative': [11], 'senescence.': [12], 'Telomerase': [13], 'functions': [14], 'as': [15, 100], 'potential': [17, 54, 80], 'regulator': [18], 'of': [19, 26, 47, 50, 55, 81, 111, 139, 145, 148, 169, 181], 'senescence': [20], 'in': [21, 83, 106, 125, 143, 192, 207, 221], 'various': [22], 'cells.': [23], 'Expression': [24], 'level': [25], 'human': [27, 204], 'telomerase': [28, 35, 123, 132, 205], 'reverse': [29], 'transcriptase': [30], '(hTERT)': [31], 'is': [32], 'correlated': [33], 'with': [34, 66, 71, 127], 'activity': [36, 206], 'and': [37, 85, 93, 97, 116, 156, 172, 191, 210, 225, 254], 'cellular': [38, 167], 'immortalization.': [39], 'In': [40, 177], 'this': [41], 'study,': [42], 'we': [43], 'investigated': [44], 'the': [45, 78, 109, 166, 255], 'effects': [46], 'ectopic': [48, 137], 'expression': [49, 138], 'hTERT': [51, 67, 140, 217], 'on': [52, 245, 259], 'proliferation': [53, 82], 'chicken': [56, 189], 'feather': [57], 'keratinocyte': [58], 'stem': [59, 88], '(FKSCs).': [61], 'We': [62, 134], 'established': [63], 'FKSCs': [64, 129, 171], 'transduced': [65], 'catalytic': [68], 'subunit': [69], 'fused': [70], 'EGFP': [72], 'marker': [73], 'gene': [74], '(hTERT‐EGFP‐FKSCs).': [75], 'hTERT‐EGFP‐FKSCs': [76, 119, 149, 164, 182], 'had': [77, 173], 'great': [79], 'vitro': [84], 'expressed': [86], 'kerainocyte': [87], 'cell': [89], 'markers': [90], 'integrin': [91], 'β1': [92], 'CD49c.': [94], 'Keratin': [95], '15': [96], 'keratin': [98], '19,': [99], 'native': [101, 128, 170], 'FKSCs,': [102], 'were': [103, 120, 150, 183], 'also': [104], 'detected': [105], 'hTERT‐EGFP‐FKSCs.': [107], 'By': [108], 'analysis': [110], 'fluorescent': [112], 'RT‐PCR,': [113], 'western': [114], 'blotting': [115], 'TRAP': [117], 'assay,': [118], 'positive': [121], 'for': [122, 202, 215, 218], 'activity,': [124], 'comparison': [126], 'showing': [130], 'no': [131, 174], 'activity.': [133, 176], 'demonstrated': [135], 'that': [136, 163], 'could': [141], 'result': [142], 'immortalization': [144], 'FKSCs.': [146], 'Tumorigenecity': [147], 'examined': [151], 'by': [152, 185], 'soft': [153], 'agar': [154], 'assay': [155], 'transplantation': [157, 186], 'into': [158, 187], 'NOD‐SCID': [159], 'mice.': [160], 'Results': [161], 'showed': [162], 'sustained': [165], 'characteristics': [168], 'transforming': [175], 'vivo': [178], 'differentiation': [179], 'multipotentials': [180], 'confirmed': [184], 'developing': [188], 'embryos': [190], 'situ': [193], 'hybridization': [194], 'analysis.': [195], 'These': [196], 'data': [197], 'provide': [198], 'novel': [200], 'framework': [201], 'understanding': [203], 'different': [208], 'species': [209], 'suggest': [211], 'new': [213], 'insight': [214], 'manipulating': [216], 'therapeutic': [219], 'purposes': [220], 'treating': [222], 'tissue': [223], 'injury': [224], 'aging.': [226], 'J.': [227], 'Exp.': [228], 'Zool.': [229], '(Mol.': [230], 'Dev.': [231], 'Evol.)': [232], '312B:872–884,': [233], '2009': [234, 237], '.': [235], '©': [236], 'Wiley‐Liss,': [238], 'Inc.': [239], '[This': [240], 'article': [241, 256], 'was': [242, 251, 257], 'published': [243], 'online': [244], '23': [246], 'June': [247], '2009.': [248], 'An': [249], 'error': [250], 'subsequently': [252], 'identified': [253], 'corrected': [258], '8': [260], 'September': [261], '2009.]': [262]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1999220169', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T19:03:36.513169', 'created_date': '2016-06-24'}