Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1998220846', 'doi': 'https://doi.org/10.1016/j.critrevonc.2003.10.004', 'title': 'Matrix metalloproteinases and matrikines in angiogenesis', 'display_name': 'Matrix metalloproteinases and matrikines in angiogenesis', 'publication_year': 2004, 'publication_date': '2004-02-07', 'ids': {'openalex': 'https://openalex.org/W1998220846', 'doi': 'https://doi.org/10.1016/j.critrevonc.2003.10.004', 'mag': '1998220846', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15036261'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.critrevonc.2003.10.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185233701', 'display_name': 'Critical Reviews in Oncology/Hematology', 'issn_l': '1040-8428', 'issn': ['1040-8428', '1879-0461'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049635748', 'display_name': 'Georges Bellon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96226040', 'display_name': 'Université de Reims Champagne-Ardenne', 'ror': 'https://ror.org/03hypw319', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I96226040']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Georges Bellon', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Molecular Biology, FRE 2534 CNRS, Faculty of Medicine, IFR-53 “Biomolécules”, University of Reims Champagne-Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Molecular Biology, FRE 2534 CNRS, Faculty of Medicine, IFR-53 “Biomolécules”, University of Reims Champagne-Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France', 'institution_ids': ['https://openalex.org/I96226040', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041446063', 'display_name': 'Laurent Martiny', 'orcid': 'https://orcid.org/0000-0002-4667-2860'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I96226040', 'display_name': 'Université de Reims Champagne-Ardenne', 'ror': 'https://ror.org/03hypw319', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I96226040']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Laurent Martiny', 'raw_affiliation_strings': ['Laboratory of Biochemistry, FRE 2534 CNRS, Faculty of Sciences, University of Reims Champagne-Ardenne, Moulin de la Housse, 51095 Reims Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry, FRE 2534 CNRS, Faculty of Sciences, University of Reims Champagne-Ardenne, Moulin de la Housse, 51095 Reims Cedex, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I96226040']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052550907', 'display_name': 'Arnaud Robinet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96226040', 'display_name': 'Université de Reims Champagne-Ardenne', 'ror': 'https://ror.org/03hypw319', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I96226040']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Arnaud Robinet', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Molecular Biology, FRE 2534 CNRS, Faculty of Medicine, IFR-53 “Biomolécules”, University of Reims Champagne-Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Molecular Biology, FRE 2534 CNRS, Faculty of Medicine, IFR-53 “Biomolécules”, University of Reims Champagne-Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France', 'institution_ids': ['https://openalex.org/I96226040', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.729, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 105, 'citation_normalized_percentile': {'value': 0.725664, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '49', 'issue': '3', 'first_page': '203', 'last_page': '220'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.65697336}, {'id': 'https://openalex.org/keywords/tumor-angiogenesis', 'display_name': 'tumor angiogenesis', 'score': 0.584387}, {'id': 'https://openalex.org/keywords/extracellular-matrix', 'display_name': 'Extracellular Matrix', 'score': 0.563995}, {'id': 'https://openalex.org/keywords/extracellular-matrix-remodeling', 'display_name': 'Extracellular Matrix Remodeling', 'score': 0.548394}, {'id': 'https://openalex.org/keywords/angiogenesis', 'display_name': 'Angiogenesis', 'score': 0.539628}, {'id': 'https://openalex.org/keywords/angiogenic-signaling', 'display_name': 'angiogenic signaling', 'score': 0.537998}, {'id': 'https://openalex.org/keywords/proteolytic-enzymes', 'display_name': 'Proteolytic enzymes', 'score': 0.519503}], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.9098749}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.8844341}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.80119044}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.65697336}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.64135545}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5966257}, {'id': 'https://openalex.org/C3019223276', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Proteolytic enzymes', 'level': 3, 'score': 0.519503}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4972277}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.43365845}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42606062}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.41589656}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37123883}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.35498208}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30995554}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.28253284}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.21964157}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.17233148}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.085549414}], 'mesh': [{'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.critrevonc.2003.10.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185233701', 'display_name': 'Critical Reviews in Oncology/Hematology', 'issn_l': '1040-8428', 'issn': ['1040-8428', '1879-0461'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15036261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 232, 'referenced_works': ['https://openalex.org/W1042093625', 'https://openalex.org/W1121473917', 'https://openalex.org/W138257409', 'https://openalex.org/W140040682', 'https://openalex.org/W1487159685', 'https://openalex.org/W1495287184', 'https://openalex.org/W1499321737', 'https://openalex.org/W1501495997', 'https://openalex.org/W1515455066', 'https://openalex.org/W1516230454', 'https://openalex.org/W1523823034', 'https://openalex.org/W1549631663', 'https://openalex.org/W1554387494', 'https://openalex.org/W1555806697', 'https://openalex.org/W1565818905', 'https://openalex.org/W1567730256', 'https://openalex.org/W1568679764', 'https://openalex.org/W1569373357', 'https://openalex.org/W1574172480', 'https://openalex.org/W1585873539', 'https://openalex.org/W1604907834', 'https://openalex.org/W1619234695', 'https://openalex.org/W1655051481', 'https://openalex.org/W1658047882', 'https://openalex.org/W1679229092', 'https://openalex.org/W168519241', 'https://openalex.org/W1727370327', 'https://openalex.org/W1740440689', 'https://openalex.org/W1785416487', 'https://openalex.org/W1830089244', 'https://openalex.org/W1832925227', 'https://openalex.org/W1862033296', 'https://openalex.org/W1885134561', 'https://openalex.org/W1886431664', 'https://openalex.org/W1922516116', 'https://openalex.org/W1941829554', 'https://openalex.org/W1947027968', 'https://openalex.org/W1963530773', 'https://openalex.org/W1963776052', 'https://openalex.org/W1964632069', 'https://openalex.org/W1967197264', 'https://openalex.org/W1968084778', 'https://openalex.org/W1968114204', 'https://openalex.org/W1968431199', 'https://openalex.org/W1969262936', 'https://openalex.org/W1969467769', 'https://openalex.org/W1970141188', 'https://openalex.org/W1970246132', 'https://openalex.org/W1971100023', 'https://openalex.org/W1971720270', 'https://openalex.org/W1972325477', 'https://openalex.org/W1973189198', 'https://openalex.org/W1974651994', 'https://openalex.org/W1975224878', 'https://openalex.org/W1976435333', 'https://openalex.org/W1976451311', 'https://openalex.org/W1977366543', 'https://openalex.org/W1978769760', 'https://openalex.org/W1980915493', 'https://openalex.org/W1985804036', 'https://openalex.org/W1986221079', 'https://openalex.org/W1986286728', 'https://openalex.org/W1987059068', 'https://openalex.org/W1988367469', 'https://openalex.org/W1991472045', 'https://openalex.org/W1993272437', 'https://openalex.org/W1993360635', 'https://openalex.org/W1995033273', 'https://openalex.org/W1998225655', 'https://openalex.org/W1998909889', 'https://openalex.org/W2000000541', 'https://openalex.org/W2003500892', 'https://openalex.org/W2003659983', 'https://openalex.org/W2003775813', 'https://openalex.org/W2005294501', 'https://openalex.org/W2006812885', 'https://openalex.org/W2007755400', 'https://openalex.org/W2007799501', 'https://openalex.org/W2010091903', 'https://openalex.org/W2010589579', 'https://openalex.org/W2010977586', 'https://openalex.org/W2011053169', 'https://openalex.org/W2011614963', 'https://openalex.org/W2012413811', 'https://openalex.org/W2013215928', 'https://openalex.org/W2016068460', 'https://openalex.org/W2016411107', 'https://openalex.org/W2017022268', 'https://openalex.org/W2017132462', 'https://openalex.org/W2018096448', 'https://openalex.org/W2018850477', 'https://openalex.org/W2020645507', 'https://openalex.org/W2022065340', 'https://openalex.org/W2022718682', 'https://openalex.org/W2023374250', 'https://openalex.org/W2024088705', 'https://openalex.org/W2024123705', 'https://openalex.org/W2024626734', 'https://openalex.org/W2026463198', 'https://openalex.org/W2026542895', 'https://openalex.org/W2027001421', 'https://openalex.org/W2027329004', 'https://openalex.org/W2027700219', 'https://openalex.org/W2028683460', 'https://openalex.org/W2029176649', 'https://openalex.org/W2031051749', 'https://openalex.org/W2032511198', 'https://openalex.org/W2036443538', 'https://openalex.org/W2037141117', 'https://openalex.org/W2037288057', 'https://openalex.org/W2039210162', 'https://openalex.org/W2039787319', 'https://openalex.org/W2040628388', 'https://openalex.org/W2041148365', 'https://openalex.org/W2041816417', 'https://openalex.org/W2042333083', 'https://openalex.org/W2042419096', 'https://openalex.org/W2045247998', 'https://openalex.org/W2045447884', 'https://openalex.org/W2046553038', 'https://openalex.org/W2047539118', 'https://openalex.org/W2048293656', 'https://openalex.org/W2048441028', 'https://openalex.org/W2049220062', 'https://openalex.org/W2050577046', 'https://openalex.org/W2051096548', 'https://openalex.org/W2052302973', 'https://openalex.org/W2053649115', 'https://openalex.org/W2054118339', 'https://openalex.org/W2054572692', 'https://openalex.org/W2058581224', 'https://openalex.org/W2058873146', 'https://openalex.org/W2059322719', 'https://openalex.org/W2059919196', 'https://openalex.org/W2059983738', 'https://openalex.org/W2060074114', 'https://openalex.org/W2061052708', 'https://openalex.org/W2062574032', 'https://openalex.org/W2063897047', 'https://openalex.org/W2064070322', 'https://openalex.org/W2064644581', 'https://openalex.org/W2065799167', 'https://openalex.org/W2068843202', 'https://openalex.org/W2068932920', 'https://openalex.org/W2070742907', 'https://openalex.org/W2072103796', 'https://openalex.org/W2072320843', 'https://openalex.org/W2072928113', 'https://openalex.org/W2074979117', 'https://openalex.org/W2076040050', 'https://openalex.org/W2078247661', 'https://openalex.org/W2078761996', 'https://openalex.org/W2078868629', 'https://openalex.org/W2080871677', 'https://openalex.org/W2081471836', 'https://openalex.org/W2083252148', 'https://openalex.org/W2083283637', 'https://openalex.org/W2083503468', 'https://openalex.org/W2083535354', 'https://openalex.org/W2084296110', 'https://openalex.org/W2085396553', 'https://openalex.org/W2086011121', 'https://openalex.org/W2086619383', 'https://openalex.org/W2088019834', 'https://openalex.org/W2088726343', 'https://openalex.org/W2088818435', 'https://openalex.org/W2090595109', 'https://openalex.org/W2092902221', 'https://openalex.org/W2093455126', 'https://openalex.org/W2094842696', 'https://openalex.org/W2095724936', 'https://openalex.org/W2096481282', 'https://openalex.org/W2097707959', 'https://openalex.org/W2101564903', 'https://openalex.org/W2102786937', 'https://openalex.org/W2109658199', 'https://openalex.org/W2110310870', 'https://openalex.org/W2114900551', 'https://openalex.org/W2119523001', 'https://openalex.org/W2120429340', 'https://openalex.org/W2122096535', 'https://openalex.org/W2127399993', 'https://openalex.org/W2128049766', 'https://openalex.org/W2128330701', 'https://openalex.org/W2130395392', 'https://openalex.org/W2130453040', 'https://openalex.org/W2131782272', 'https://openalex.org/W2131798870', 'https://openalex.org/W2132883779', 'https://openalex.org/W2138423846', 'https://openalex.org/W2139303048', 'https://openalex.org/W2141836567', 'https://openalex.org/W2142610113', 'https://openalex.org/W2143142038', 'https://openalex.org/W2144328981', 'https://openalex.org/W2146519773', 'https://openalex.org/W2148413520', 'https://openalex.org/W2149360108', 'https://openalex.org/W2150552267', 'https://openalex.org/W2151619744', 'https://openalex.org/W2152954189', 'https://openalex.org/W2153093234', 'https://openalex.org/W2154061285', 'https://openalex.org/W2154086195', 'https://openalex.org/W2155699260', 'https://openalex.org/W2158965678', 'https://openalex.org/W2161457594', 'https://openalex.org/W2161659842', 'https://openalex.org/W2162639406', 'https://openalex.org/W2164809985', 'https://openalex.org/W2165482404', 'https://openalex.org/W2166084156', 'https://openalex.org/W2169970968', 'https://openalex.org/W2170830743', 'https://openalex.org/W2171998177', 'https://openalex.org/W2172114097', 'https://openalex.org/W2172240949', 'https://openalex.org/W2218570030', 'https://openalex.org/W2223292', 'https://openalex.org/W2276184075', 'https://openalex.org/W2325441863', 'https://openalex.org/W2397741974', 'https://openalex.org/W2400559282', 'https://openalex.org/W2418200037', 'https://openalex.org/W29711487', 'https://openalex.org/W311788996', 'https://openalex.org/W4232261933', 'https://openalex.org/W4248515563', 'https://openalex.org/W4249031617', 'https://openalex.org/W4250428608', 'https://openalex.org/W4250908540', 'https://openalex.org/W4294352168'], 'related_works': ['https://openalex.org/W2519820356', 'https://openalex.org/W251682942', 'https://openalex.org/W2470284246', 'https://openalex.org/W2367939396', 'https://openalex.org/W2363211455', 'https://openalex.org/W2166581295', 'https://openalex.org/W2158732939', 'https://openalex.org/W2102688698', 'https://openalex.org/W2010141405', 'https://openalex.org/W1795654691'], 'abstract_inverted_index': {'Neoangiogenesis,': [0], 'the': [1, 60, 105, 132, 156], 'formation': [2], 'of': [3, 17, 56, 83, 107, 131, 137, 158, 170], 'new': [4, 150], 'blood': [5], 'capillaries': [6], 'from': [7], 'pre-existing': [8, 50], 'vessels,': [9], 'plays': [10], 'an': [11, 38], 'important': [12, 81], 'role': [13], 'in': [14, 23, 116, 126, 176], 'a': [15, 149], 'number': [16, 136], 'physiological': [18], 'and': [19, 26, 45, 92, 100, 109, 114, 167], 'pathological': [20], 'processes,': [21], 'particularly': [22], 'tumor': [24, 43, 165], 'growth': [25, 166], 'metastasis.': [27, 168], 'Extracellular': [28], 'proteolysis': [29], 'by': [30, 66, 71, 97], 'matrix': [31], 'metalloproteinases': [32, 113], 'or': [33, 49, 78, 121], 'other': [34, 119], 'neutral': [35], 'proteinases': [36], 'is': [37], 'absolute': [39], 'requirement': [40], 'for': [41, 155], 'initiating': [42], 'invasion': [44], 'angiogenesis.': [46], 'Cryptic': [47], 'segments': [48, 99], 'domains': [51], 'within': [52], 'larger': [53], 'proteins,': [54], 'most': [55], 'them': [57, 171], 'belonging': [58], 'to': [59, 104, 152], 'extracellular': [61], 'matrix,': [62], 'can': [63, 76], 'be': [64], 'exposed': [65], 'conformational': [67], 'changes': [68], 'and/or': [69], 'generated': [70], 'partial': [72], 'enzymatic': [73], 'hydrolysis.': [74], 'They': [75], 'positively': [77], 'negatively': [79], 'regulate': [80], 'functions': [82], 'endothelial': [84], 'cells': [85], 'including': [86], 'adhesion,': [87], 'migration,': [88], 'proliferation,': [89], 'cell': [90], 'survival': [91], 'cell–cell': [93], 'interactions.': [94], 'Such': [95], 'regulations': [96], 'cryptic': [98], 'proteolytic': [101], 'fragments': [102], 'led': [103], 'concept': [106], 'matricryptins': [108], 'matrikines,': [110], 'respectively.': [111], 'Matrix': [112], 'matrikines': [115, 138], 'conjunction': [117], 'with': [118], 'pro-': [120], 'anti-angiogenic': [122, 144, 159], 'factors': [123], 'might': [124], 'act': [125], 'concert': [127], 'at': [128, 163], 'any': [129], 'step': [130], 'angiogenesis': [133], 'process.': [134], 'A': [135], 'have': [139], 'been': [140], 'identified': [141], 'as': [142], 'potent': [143], 'factors,': [145], 'which': [146], 'could': [147], 'provide': [148], 'alternative': [151], 'anti-proteolytic': [153], 'strategies': [154], 'development': [157], 'therapeutic': [160], 'molecules': [161], 'aimed': [162], 'inhibiting': [164], 'Some': [169], 'are': [172], 'currently': [173], 'being': [174], 'investigated': [175], 'clinical': [177], 'trials.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1998220846', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-27T01:04:40.750047', 'created_date': '2016-06-24'}