Publication Information

{'id': 'https://openalex.org/W1989283249', 'doi': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'title': 'MOLECULAR MECHANISM OF THE DEVELOPMENT AND DETERIORATION OF ACUTE PANCREATITIS', 'display_name': 'MOLECULAR MECHANISM OF THE DEVELOPMENT AND DETERIORATION OF ACUTE PANCREATITIS', 'publication_year': 2007, 'publication_date': '2007-06-15', 'ids': {'openalex': 'https://openalex.org/W1989283249', 'doi': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'mag': '1989283249'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10058814', 'display_name': 'Pancreas', 'issn_l': '0885-3177', 'issn': ['0885-3177', '1536-4828'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024376962', 'display_name': 'Masahiko Hirota', 'orcid': 'https://orcid.org/0000-0001-7651-5375'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masahiko Hirota', 'raw_affiliation_strings': ['Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'Suizo Vol 21, No 2, pp 47-55.'], 'affiliations': [{'raw_affiliation_string': 'Suizo Vol 21, No 2, pp 47-55.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052144423', 'display_name': 'Masaki Ohmuraya', 'orcid': 'https://orcid.org/0000-0002-8352-6598'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaki Ohmuraya', 'raw_affiliation_strings': ['Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'Suizo Vol 21, No 2, pp 47-55.'], 'affiliations': [{'raw_affiliation_string': 'Suizo Vol 21, No 2, pp 47-55.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070135306', 'display_name': 'Hideo Baba', 'orcid': 'https://orcid.org/0000-0002-2129-9086'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideo Baba', 'raw_affiliation_strings': ['Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'Suizo Vol 21, No 2, pp 47-55.'], 'affiliations': [{'raw_affiliation_string': 'Suizo Vol 21, No 2, pp 47-55.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.', 'institution_ids': ['https://openalex.org/I96036126']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.334, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.533971, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 63, 'max': 70}, 'biblio': {'volume': '35', 'issue': '1', 'first_page': '84', 'last_page': '84'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10760', 'display_name': 'Diagnosis and Management of Pancreatitis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10760', 'display_name': 'Diagnosis and Management of Pancreatitis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11855', 'display_name': "Intussusception and Meckel's Diverticulum", 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.97, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/psti', 'display_name': 'PstI', 'score': 0.85503423}, {'id': 'https://openalex.org/keywords/acute-pancreatitis', 'display_name': 'Acute Pancreatitis', 'score': 0.560303}, {'id': 'https://openalex.org/keywords/pancreatic-disease', 'display_name': 'Pancreatic Disease', 'score': 0.516553}], 'concepts': [{'id': 'https://openalex.org/C2776670229', 'wikidata': 'https://www.wikidata.org/wiki/Q854573', 'display_name': 'Acute pancreatitis', 'level': 2, 'score': 0.86383665}, {'id': 'https://openalex.org/C2780397633', 'wikidata': 'https://www.wikidata.org/wiki/Q6090491', 'display_name': 'PstI', 'level': 4, 'score': 0.85503423}, {'id': 'https://openalex.org/C2780340462', 'wikidata': 'https://www.wikidata.org/wiki/Q127450', 'display_name': 'Trypsin', 'level': 3, 'score': 0.7603022}, {'id': 'https://openalex.org/C2775967933', 'wikidata': 'https://www.wikidata.org/wiki/Q1527888', 'display_name': 'Pancreatitis', 'level': 2, 'score': 0.69464266}, {'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.55053467}, {'id': 'https://openalex.org/C2781286802', 'wikidata': 'https://www.wikidata.org/wiki/Q421373', 'display_name': 'Trypsinogen', 'level': 4, 'score': 0.544277}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.43262982}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.4130073}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3662045}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32661512}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.31533045}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.22067541}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18368354}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C128319531', 'wikidata': 'https://www.wikidata.org/wiki/Q219715', 'display_name': 'Restriction enzyme', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10058814', 'display_name': 'Pancreas', 'issn_l': '0885-3177', 'issn': ['0885-3177', '1536-4828'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://journals.lww.com/pancreasjournal/Fulltext/2007/07000/MOLECULAR_MECHANISM_OF_THE_DEVELOPMENT_AND.18.aspx', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.mpa.0000278659.59384.20', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10058814', 'display_name': 'Pancreas', 'issn_l': '0885-3177', 'issn': ['0885-3177', '1536-4828'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1563800735', 'https://openalex.org/W1843267607', 'https://openalex.org/W1971032058', 'https://openalex.org/W1973778543', 'https://openalex.org/W1985110968', 'https://openalex.org/W1987165822', 'https://openalex.org/W1989769122', 'https://openalex.org/W1989821468', 'https://openalex.org/W1992509386', 'https://openalex.org/W1995347602', 'https://openalex.org/W1997718215', 'https://openalex.org/W1998750651', 'https://openalex.org/W2007211714', 'https://openalex.org/W2015152562', 'https://openalex.org/W2015969360', 'https://openalex.org/W2020202884', 'https://openalex.org/W2020259164', 'https://openalex.org/W2023243075', 'https://openalex.org/W2033780498', 'https://openalex.org/W2041258477', 'https://openalex.org/W2044427614', 'https://openalex.org/W2045436965', 'https://openalex.org/W2050164769', 'https://openalex.org/W2058052082', 'https://openalex.org/W2059699095', 'https://openalex.org/W2069370434', 'https://openalex.org/W2073024525', 'https://openalex.org/W2080097016', 'https://openalex.org/W2086741871', 'https://openalex.org/W2093142281', 'https://openalex.org/W2093587531', 'https://openalex.org/W2094669359', 'https://openalex.org/W2094873369', 'https://openalex.org/W2104661464', 'https://openalex.org/W2138405547', 'https://openalex.org/W2151505671', 'https://openalex.org/W2157783962', 'https://openalex.org/W2162100863', 'https://openalex.org/W2183482681', 'https://openalex.org/W2184904249', 'https://openalex.org/W2273171223', 'https://openalex.org/W2489502796'], 'related_works': ['https://openalex.org/W2168597484', 'https://openalex.org/W2138695913', 'https://openalex.org/W2088680591', 'https://openalex.org/W2078663102', 'https://openalex.org/W2071117056', 'https://openalex.org/W2055577277', 'https://openalex.org/W2037773161', 'https://openalex.org/W2033622898', 'https://openalex.org/W202519896', 'https://openalex.org/W2010433360'], 'abstract_inverted_index': {':': [0], 'Under': [1], 'normal': [2], 'conditions,': [3], 'trypsin': [4, 17, 24, 42, 96], 'activity': [5], 'is': [6], 'properly': [7], 'suppressed': [8], 'in': [9], 'the': [10, 45, 56, 69, 85, 108, 112], 'pancreatic': [11, 22, 31], 'acinar': [12, 32], 'cells.': [13, 63], 'Small': [14], 'amount': [15], 'of': [16, 38, 47, 52, 58, 73, 89, 94, 114], 'can': [18, 65], 'be': [19, 66], 'inactivated': [20], 'by': [21], 'secretory': [23], 'inhibitor': [25], '(PSTI)': [26], 'thereby': [27], 'preventing': [28], 'damage': [29, 62], 'to': [30, 55], 'cells': [33], 'as': [34, 68, 107], 'a': [35, 49], 'first': [36], 'line': [37], 'defense.': [39], 'However,': [40], 'if': [41], 'activation': [43, 57], 'exceeds': [44], 'capacity': [46], 'PSTI,': [48], 'subsequent': [50], 'cascade': [51], 'events': [53], 'leads': [54], 'various': [59], 'proteases': [60], 'that': [61], 'This': [64], 'interpreted': [67], 'main': [70], 'causative': [71], 'agent': [72], 'pancreatitis': [74], 'onset.': [75], 'Ischemia,': [76], 'autodigestion,': [77], 'and': [78, 103], 'systemic': [79], 'inflammatory': [80], 'response': [81], 'syndrome': [82], '(SIRS)/sepsis': [83], 'are': [84, 105], 'major': [86], 'aggravation': [87, 113], 'mechanisms': [88], 'acute': [90, 115], 'pancreatitis.': [91, 116], 'The': [92], 'role': [93], 'trypsin,': [95], 'receptor': [97], '(protease-activated': [98], 'receptor-2:': [99], 'PAR-2),': [100], 'pro-inflammatory': [101], 'cytokines,': [102], 'endothelins': [104], 'described': [106], 'key': [109], 'molecules': [110], 'for': [111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989283249', 'counts_by_year': [], 'updated_date': '2024-09-19T03:18:22.511527', 'created_date': '2016-06-24'}