Title: Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men
Abstract: The effect of high-dose atorvastatin treatment in normocholesterolemic patients was studied to answer the following questions: Is there a detectable benefit on endothelial function and inflammation within 24 to 48 hours after initiation of treatment 1 Aronow H.D. Topol E.J. Roe M.T. Houghtaling P.L. Wolski K.E. Lincoff A.M. Harrington R.A. Califf R.M. Ohman E.M. Kleiman N.S. et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes an observational study. Lancet. 2001; 357: 1063-1068 Abstract Full Text Full Text PDF PubMed Scopus (300) Google Scholar , 2 Dupuis J. Tardif J.C. Cernacek P. Theroux P. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial. Circulation. 1999; 99: 3227-3233 Crossref PubMed Scopus (512) Google Scholar , 3 Schwartz G.G. Olsson A.G. Ezekowitz M.D. Ganz P. Oliver M.F. Waters D. Zeiher A. Chaitman B.R. Leslie S. Stern T. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes the MIRACL study: a randomized controlled trial. JAMA. 2001; 285: 1711-1718 Crossref PubMed Google Scholar ? Does atorvastatin alter vascular function independent of serum cholesterol? And finally, is there a deleterious effect of acute statin withdrawal with respect to vascular function and inflammation 4 Thomas M. Mann J. Increased thrombotic vascular events after change of statin. Lancet. 1998; 352: 1830-1831 Abstract Full Text Full Text PDF PubMed Scopus (114) Google Scholar , 5 Laufs U. Endres M. Custodis F. Gertz K. Nickenig G. Liao J.K. Böhm M. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation. 2000; 102: 3104-3110 Crossref PubMed Scopus (255) Google Scholar ?
Publication Year: 2001
Publication Date: 2001-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 182
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