Title: Influence of Growth Hormone, Fasting and Alloxan Diabetes on Pituitary, Tibia and Adrenal Glycogen Levels in the Rat
Abstract: The effects of fasting and growth hormone (GH) injections on pituitary, adrenal and tibial glycogen levels were studied in normal and alloxan diabetic rats. Fasting caused an initial decrease followed by a progressive rise in pituitary and tibial glycogen in nondiabetic rats. GH decreased all tissue glycogen levels 24 hr after the first injection but only pituitary and tibial glycogen levels remained depressed with additional GH injections in nondiabetic rats. GH decreased the supranormal adrenal and pituitary glycogen levels of diabetic rats as well as furthering the decrement in hypophyseal tissue glycogen if fasting also were induced. Diabetic rats had subnormal tibial glycogen levels. The possibility is discussed that hypophyseal glycogen levels may assist in regulating GH secretion and that plasma GH and/or glucose exerts a negative feedback via altering hypophyseal carbohydrate metabolism.
Publication Year: 1970
Publication Date: 1970-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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