Title: Intraerythrocytic Regulatory Mechanisms for Control of Glycolysis, DPT Levels and pH
Abstract: The patterns of erythrocyte glycolytic intermediates in freshly drawn blood from patients with hypoxic disease can be used to evaluate the in vivo control of glycolysis and of DPG levels in these diseases. In studies of anemia due to bone marrow replacement from leukemia all of the red cell intermediates, beginning with glucose-6-phosphate (G6P) are increased. These data, together with evidence indicating increased glucose consumption in anemia, indicate an activation of hexokinase, the first step of glycolysis, as a part of the mechanism whereby erythrocyte glycolytic levels are increased in anemia. A further observation in anemia is that the level of fructose diphosphate (FDP), the third intermediate of the pathway, is increased out of proportion to the other intermediates. This finding suggests an activation of the enzyme preceding FDP, namely phosphofructokinase (PFK), as well as hexokinase.
Publication Year: 1972
Publication Date: 1972-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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