Title: Lipid Peroxidation–Derived DNA Adducts and the Role in Inflammation‐Related Carcinogenesis
Abstract: Chapter 5 Lipid Peroxidation–Derived DNA Adducts and the Role in Inflammation-Related Carcinogenesis Helmut Bartsch, Helmut BartschSearch for more papers by this authorUrmila Jagadeesan Nair, Urmila Jagadeesan NairSearch for more papers by this author Helmut Bartsch, Helmut BartschSearch for more papers by this authorUrmila Jagadeesan Nair, Urmila Jagadeesan NairSearch for more papers by this author Book Editor(s):Yusuke Hiraku, Yusuke Hiraku Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, JapanSearch for more papers by this authorShosuke Kawanishi, Shosuke Kawanishi Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, JapanSearch for more papers by this authorHiroshi Ohshima, Hiroshi Ohshima Department of Nutritional and Environmental Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this author First published: 04 April 2014 https://doi.org/10.1002/9781118826621.ch5Citations: 2 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Chronic infection and persistent inflammation are now recognized as important risk factors in many human cancers. Emerging evidence suggests that cancer-related inflammatory processes cause tissue damage and genetic instability involved in the initiation, promotion, and progression of carcinogenesis. Reactive oxygen (ROS) and nitrogen (RNS) species and lipid peroxidation (LPO)–mediated tissue damage play a major role in inflammation-related malignancies. This chapter provides information on methods for quantifying some representative lipid peroxidation (LPO)-derived DNA adducts in human biomonitoring studies. It summarizes results from biomarker applications that have provided insights intomechanisms of cancer causation and possibilities of preventive measures in human at risk subjects. Data compiled in this chapter provide evidence that persistent oxidative/nitrative stress and excess LPO are induced by chronic inflammatory processes and infections, causing massive DNA damage from endogenous sources. References Coussens LM, Werb Z. Inflammation and cancer. 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Publication Year: 2014
Publication Date: 2014-04-04
Language: en
Type: other
Indexed In: ['crossref']
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