Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1844107241', 'doi': 'https://doi.org/10.18632/oncotarget.6169', 'title': 'Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR', 'display_name': 'Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR', 'publication_year': 2015, 'publication_date': '2015-10-19', 'ids': {'openalex': 'https://openalex.org/W1844107241', 'doi': 'https://doi.org/10.18632/oncotarget.6169', 'mag': '1844107241', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26496029', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4868683'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6169', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6169&path%5B%5D=15419', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6169&path%5B%5D=15419', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017991794', 'display_name': 'Sue Ellen Verbrugge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['NL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sue Ellen Verbrugge', 'raw_affiliation_strings': ['Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.', 'Present address: Department of Clinical Chemistry, UMCU, Utrecht, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Present address: Department of Clinical Chemistry, UMCU, Utrecht, The Netherlands.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049992488', 'display_name': 'Marjon Al', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marjon Al', 'raw_affiliation_strings': ['Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013852274', 'display_name': 'Yehuda G. Assaraf', 'orcid': 'https://orcid.org/0000-0001-6692-8221'}, 'institutions': [{'id': 'https://openalex.org/I174306211', 'display_name': 'Technion – Israel Institute of Technology', 'ror': 'https://ror.org/03qryx823', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I174306211']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Yehuda G. Assaraf', 'raw_affiliation_strings': ['The Fred Wyszkowsky Cancer Research Laboratory, Faculty of Biology, The Technion-Israel Institute of Technology, Haifa, Israel.'], 'affiliations': [{'raw_affiliation_string': 'The Fred Wyszkowsky Cancer Research Laboratory, Faculty of Biology, The Technion-Israel Institute of Technology, Haifa, Israel.', 'institution_ids': ['https://openalex.org/I174306211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031445293', 'display_name': 'Sarah Kammerer', 'orcid': 'https://orcid.org/0000-0002-9284-2242'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Sarah Kammerer', 'raw_affiliation_strings': ['Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands', 'Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.', 'Present address: Institute of Biophysics, Medical University of Graz, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Present address: Institute of Biophysics, Medical University of Graz, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063387835', 'display_name': 'Durga M. S. H. Chandrupatla', 'orcid': 'https://orcid.org/0000-0003-2911-3917'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Durga M.S.H. Chandrupatla', 'raw_affiliation_strings': ['Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands', 'Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020883449', 'display_name': 'Richard J. Honeywell', 'orcid': 'https://orcid.org/0000-0001-9415-5959'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Richard Honeywell', 'raw_affiliation_strings': ['Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084411642', 'display_name': 'Rene P.J. Musters', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Rene P.J. Musters', 'raw_affiliation_strings': ['Department of Physiology, VU University, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, VU University, Amsterdam, The Netherlands.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041229832', 'display_name': 'Elisa Giovannetti', 'orcid': 'https://orcid.org/0000-0002-7565-7504'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Elisa Giovannetti', 'raw_affiliation_strings': ['Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051015262', 'display_name': 'Tom O’Toole', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tom O’Toole', 'raw_affiliation_strings': ['Department of Molecular Cell Biology, VU University Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Cell Biology, VU University Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049292621', 'display_name': 'George L. Scheffer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'George L. Scheffer', 'raw_affiliation_strings': ['Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047201420', 'display_name': 'David Krige', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104024', 'display_name': 'Immunocore (United Kingdom)', 'ror': 'https://ror.org/014xzez86', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210104024']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Krige', 'raw_affiliation_strings': ['Chroma Therapeutics Ltd, Abingdon, United Kingdom.', 'Present address: Immunocore Ltd, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Present address: Immunocore Ltd, Oxford, UK', 'institution_ids': ['https://openalex.org/I4210104024']}, {'raw_affiliation_string': 'Chroma Therapeutics Ltd, Abingdon, United Kingdom.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053105927', 'display_name': 'Tanja D. de Gruijl', 'orcid': 'https://orcid.org/0000-0003-1464-8978'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tanja D. de Gruijl', 'raw_affiliation_strings': ['Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065784242', 'display_name': 'Hans W.M. Niessen', 'orcid': 'https://orcid.org/0000-0001-9404-9822'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hans W.M. Niessen', 'raw_affiliation_strings': ['Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075695885', 'display_name': 'Willem F. Lems', 'orcid': 'https://orcid.org/0000-0002-6885-3953'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Willem F. Lems', 'raw_affiliation_strings': ['Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042938924', 'display_name': 'Pieternella A. Kramer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146510', 'display_name': 'Isala', 'ror': 'https://ror.org/046a2wj10', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146510']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Pieternella A. Kramer', 'raw_affiliation_strings': ['Isala Hospital, Zwolle, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Isala Hospital, Zwolle, The Netherlands.', 'institution_ids': ['https://openalex.org/I4210146510']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085426388', 'display_name': 'Rik J. Scheper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Rik J. Scheper', 'raw_affiliation_strings': ['Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070729528', 'display_name': 'Jacqueline Cloos', 'orcid': 'https://orcid.org/0000-0001-9150-8026'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jacqueline Cloos', 'raw_affiliation_strings': ['Department of Pediatric Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018592613', 'display_name': 'Gert J. Ossenkoppele', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gert J. Ossenkoppele', 'raw_affiliation_strings': ['Department of Hematology, VU University medical center, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, VU University medical center, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035296183', 'display_name': 'Godefridus J. Peters', 'orcid': 'https://orcid.org/0000-0002-5447-2877'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Godefridus J. Peters', 'raw_affiliation_strings': ['Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical oncology, VU university medical center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007946879', 'display_name': 'Gerrit Jansen', 'orcid': 'https://orcid.org/0000-0001-8190-8368'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gerrit Jansen', 'raw_affiliation_strings': ['Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.179, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.780137, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '7', 'issue': '5', 'first_page': '5240', 'last_page': '5257'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Targeted Protein Degradation in Biomedical Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Role of Histone Deacetylases in Cellular Regulation', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acetylation', 'display_name': 'Acetylation', 'score': 0.465635}], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.80112994}, {'id': 'https://openalex.org/C108215921', 'wikidata': 'https://www.wikidata.org/wiki/Q603741', 'display_name': 'Prodrug', 'level': 2, 'score': 0.797573}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.5601979}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.5393337}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.53766185}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.47095165}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.4252325}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40832332}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.404938}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35976803}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.22571182}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22108352}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.12363747}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.0995186}], 'mesh': [{'descriptor_ui': 'D000626', 'descriptor_name': 'Aminopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002265', 'descriptor_name': 'Carboxylic Ester Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000626', 'descriptor_name': 'Aminopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002265', 'descriptor_name': 'Carboxylic Ester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066292', 'descriptor_name': 'Lipid Droplets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011355', 'descriptor_name': 'Prodrugs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011355', 'descriptor_name': 'Prodrugs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6169', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6169&path%5B%5D=15419', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4868683', 'pdf_url': 'https://europepmc.org/articles/pmc4868683?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868683', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26496029', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6169', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6169&path%5B%5D=15419', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W1495123612', 'https://openalex.org/W1523693806', 'https://openalex.org/W1553539229', 'https://openalex.org/W1583557220', 'https://openalex.org/W1691930647', 'https://openalex.org/W1805898977', 'https://openalex.org/W1849728743', 'https://openalex.org/W1862079335', 'https://openalex.org/W1871566045', 'https://openalex.org/W1940068179', 'https://openalex.org/W1969989200', 'https://openalex.org/W1973432561', 'https://openalex.org/W1973470114', 'https://openalex.org/W1974730258', 'https://openalex.org/W1975229775', 'https://openalex.org/W1975286848', 'https://openalex.org/W1983342808', 'https://openalex.org/W1983521336', 'https://openalex.org/W1990854324', 'https://openalex.org/W1998445948', 'https://openalex.org/W2004341894', 'https://openalex.org/W2010163650', 'https://openalex.org/W2015746068', 'https://openalex.org/W2019943090', 'https://openalex.org/W2020780403', 'https://openalex.org/W2022335352', 'https://openalex.org/W2026215813', 'https://openalex.org/W2027976496', 'https://openalex.org/W2029094565', 'https://openalex.org/W2032261812', 'https://openalex.org/W2036299072', 'https://openalex.org/W2038371153', 'https://openalex.org/W2038867755', 'https://openalex.org/W2044191806', 'https://openalex.org/W2048214220', 'https://openalex.org/W2049517768', 'https://openalex.org/W2049843699', 'https://openalex.org/W2059941395', 'https://openalex.org/W2060024988', 'https://openalex.org/W2062646606', 'https://openalex.org/W2071149267', 'https://openalex.org/W2073900832', 'https://openalex.org/W2084162137', 'https://openalex.org/W2087728192', 'https://openalex.org/W2089492300', 'https://openalex.org/W2092628520', 'https://openalex.org/W2094517081', 'https://openalex.org/W2100510340', 'https://openalex.org/W2102561304', 'https://openalex.org/W2103818458', 'https://openalex.org/W2105961905', 'https://openalex.org/W2115603990', 'https://openalex.org/W2122245179', 'https://openalex.org/W2123383613', 'https://openalex.org/W2127063807', 'https://openalex.org/W2128442187', 'https://openalex.org/W2128832687', 'https://openalex.org/W2131536053', 'https://openalex.org/W2134806571', 'https://openalex.org/W2139192127', 'https://openalex.org/W2140737563', 'https://openalex.org/W2140802932', 'https://openalex.org/W2141729412', 'https://openalex.org/W2151049164', 'https://openalex.org/W2151639840', 'https://openalex.org/W2152420092', 'https://openalex.org/W2153497031', 'https://openalex.org/W2153607816', 'https://openalex.org/W2155069742', 'https://openalex.org/W2155711100', 'https://openalex.org/W2156936195', 'https://openalex.org/W2162327900', 'https://openalex.org/W2162657734', 'https://openalex.org/W2171490806', 'https://openalex.org/W3023828467'], 'related_works': ['https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597', 'https://openalex.org/W2019551003'], 'abstract_inverted_index': {'//': [0, 244], 'Sue': [1], 'Ellen': [2], 'Verbrugge': [3], '1,11': [4], ',': [5, 9, 14, 18, 23, 27, 32, 36, 40, 45, 49, 55, 60, 65, 70, 75, 79, 84], 'Marjon': [6], 'Al': [7], '1': [8, 64, 92, 93], 'Yehuda': [10], 'G.': [11], 'Assaraf': [12], '2': [13, 109], 'Sarah': [15], 'Kammerer': [16], '1,3,12': [17], 'Durga': [19], 'M.S.H.': [20], 'Chandrupatla': [21], '1,3': [22], 'Richard': [24], 'Honeywell': [25], '3': [26, 35, 54, 88, 126], 'Rene': [28], 'P.J.': [29], 'Musters': [30], '4': [31, 138], 'Elisa': [33], 'Giovannetti': [34], 'Tom': [37], "O'Toole": [38], '5': [39, 147], 'George': [41], 'L.': [42], 'Scheffer': [43], '6': [44, 59, 74, 158], 'David': [46], 'Krige': [47], '7,13': [48], 'Tanja': [50], 'D.': [51], 'de': [52], 'Gruijl': [53], 'Hans': [56], 'W.M.': [57], 'Niessen': [58], 'Willem': [61], 'F.': [62], 'Lems': [63], 'Pieternella': [66], 'A.': [67], 'Kramer': [68], '8': [69, 180], 'Rik': [71], 'J.': [72, 81, 86], 'Scheper': [73], 'Jacqueline': [76], 'Cloos': [77], '9': [78, 186], 'Gert': [80], 'Ossenkoppele': [82], '10': [83, 198], 'Godefridus': [85], 'Peters': [87], 'and': [89, 99, 162, 325, 369, 374, 399, 415, 449], 'Gerrit': [90, 241], 'Jansen': [91], 'Department': [94, 127, 139, 148, 187, 199, 212], 'of': [95, 117, 122, 128, 140, 149, 160, 188, 200, 213, 224, 228, 281, 300, 389, 396, 404, 420, 433, 446], 'Rheumatology,': [96], 'Amsterdam': [97], 'Rheumatology': [98], 'Immunology': [100], 'Center,': [101, 105, 134, 169, 194, 205], 'VU': [102, 131, 142, 153, 166, 191, 202], 'University': [103, 132, 167, 192, 203, 227], 'Medical': [104, 129, 133, 168, 193, 204, 226], 'Amsterdam,': [106, 135, 144, 155, 170, 195, 206], 'The': [107, 110, 119, 136, 145, 156, 171, 184, 196, 207, 218, 380], 'Netherlands': [108, 137, 146, 157, 172, 185, 197, 208, 219], 'Fred': [111], 'Wyszkowsky': [112], 'Cancer': [113], 'Research': [114], 'Laboratory,': [115], 'Faculty': [116], 'Biology,': [118, 152], 'Technion-Israel': [120], 'Institute': [121, 223], 'Technology,': [123], 'Haifa,': [124], 'Israel': [125], 'Oncology,': [130], 'Physiology,': [141], 'University,': [143, 154], 'Molecular': [150], 'Cell': [151], 'Departments': [159], 'Pathology': [161], 'Cardiac': [163], 'Surgery,': [164], 'ICaR-VU,': [165], '7': [173], 'Chroma': [174], 'Therapeutics': [175], 'Ltd,': [176, 236], 'Abingdon,': [177], 'United': [178], 'Kingdom': [179], 'Isala': [181], 'Hospital,': [182], 'Zwolle,': [183], 'Pediatric': [189], 'Oncology/Hematology,': [190], 'Hematology,': [201], '11': [209], 'Present': [210, 221, 233], 'address:': [211, 222, 234], 'Clinical': [214], 'Chemistry,': [215], 'UMCU,': [216], 'Utrecht,': [217], '12': [220], 'Biophysics,': [225], 'Graz,': [229, 230], 'Austria': [231], '13': [232], 'Immunocore': [235], 'Oxford,': [237], 'UK': [238], 'Correspondence': [239], 'to:': [240], 'Jansen,': [242], 'email:': [243], 'Keywords': [245], ':': [246, 254, 259, 264], 'aminopeptidase,': [247], 'carboxylesterase,': [248], 'lipid': [249, 413], 'droplets,': [250, 414], 'mTOR,': [251], 'rapamycin': [252], 'Received': [253], 'August': [255], '11,': [256], '2015': [257, 262, 267], 'Accepted': [258], 'October': [260, 265], '04,': [261], 'Published': [263], '19,': [266], 'Abstract': [268], 'Aminopeptidase': [269], 'inhibitors': [270], 'are': [271], 'receiving': [272], 'attention': [273], 'as': [274, 348], 'combination': [275], 'chemotherapeutic': [276], 'agents': [277], 'for': [278], 'the': [279, 287, 297, 405, 421, 426, 436, 443], 'treatment': [280], 'refractory': [282], 'acute': [283, 357], 'myeloid': [284, 317, 358, 365, 460], 'leukemia.': [285], 'However,': [286], 'factors': [288], 'determining': [289], 'therapeutic': [290], 'efficacy': [291], 'remain': [292], 'elusive.': [293], 'Here': [294], 'we': [295], 'identified': [296], 'molecular': [298, 444], 'basis': [299, 445], 'acquired': [301], 'resistance': [302, 448, 458], 'to': [303, 333, 435, 454], 'CHR2863,': [304], 'an': [305, 313], 'orally': [306], 'available': [307], 'hydrophobic': [308], 'aminopeptidase': [309], 'inhibitor': [310, 438], 'prodrug': [311, 350], 'with': [312, 371, 394, 430], 'esterase-sensitive': [314], 'motif,': [315], 'in': [316, 356, 411, 459], 'leukemia': [318, 359, 366, 461], 'cells.': [319, 462], 'CHR2863': [320, 378, 447], 'enters': [321], 'cells': [322, 384], 'by': [323], 'diffusion': [324], 'is': [326], 'retained': [327], 'therein': [328], 'upon': [329], 'esterase': [330], 'activity-mediated': [331], 'conversion': [332], 'its': [334], 'hydrophilic': [335], 'active': [336], 'metabolite': [337], 'drug': [338, 382, 391, 457], 'CHR6768,': [339], 'thereby': [340], 'exerting': [341], 'amino': [342], 'acid': [343], 'depletion.': [344], 'Carboxylesterases': [345], '(CES)': [346], 'serve': [347], 'candidate': [349], 'activating': [351], 'enzymes': [352], 'given': [353], 'CES1': [354, 397], 'expression': [355], 'specimens.': [360], 'We': [361], 'established': [362], 'two': [363], 'novel': [364, 452], 'sublines': [367], 'U937/CHR2863(200)': [368], 'U937/CHR2863(5uM),': [370], 'low': [372], '(14-fold)': [373], 'high': [375], 'level': [376], '(270-fold)': [377], 'resistance.': [379], 'latter': [381, 427], 'resistant': [383], 'displayed:': [385], '(i)': [386], 'complete': [387], 'loss': [388], 'CES1-mediated': [390], 'activation': [392, 419], 'associated': [393], 'down-regulation': [395], 'mRNA': [398], 'protein,': [400], '(ii)': [401], 'marked': [402], 'retention/sequestration': [403], 'prodrug,': [406], '(iii)': [407], 'a': [408, 417, 431, 451], 'substantial': [409], 'increase': [410], 'intracellular': [412], '(iv)': [416], 'dominant': [418], 'pro-survival': [422], 'Akt/mTOR': [423], 'pathway.': [424], 'Remarkably,': [425], 'feature': [428], 'coincided': [429], 'gain': [432], 'sensitivity': [434], 'mTOR': [437], 'rapamycin.': [439], 'These': [440], 'finding': [441], 'delineate': [442], 'offer': [450], 'modality': [453], 'overcome': [455], 'this': [456]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1844107241', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-26T00:47:59.220668', 'created_date': '2016-06-24'}