Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1511563935', 'doi': 'https://doi.org/10.1016/s0014-4827(03)00129-0', 'title': 'Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression ☆ ☆This article contains data from the theses of A.W. and Y.Y.', 'display_name': 'Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression ☆ ☆This article contains data from the theses of A.W. and Y.Y.', 'publication_year': 2003, 'publication_date': '2003-04-25', 'ids': {'openalex': 'https://openalex.org/W1511563935', 'doi': 'https://doi.org/10.1016/s0014-4827(03)00129-0', 'mag': '1511563935', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12799187'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-4827(03)00129-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132505712', 'display_name': 'Experimental Cell Research', 'issn_l': '0014-4827', 'issn': ['0014-4827', '1090-2422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053323108', 'display_name': 'Andrea Witteck', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andrea Witteck', 'raw_affiliation_strings': ['‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,'], 'affiliations': [{'raw_affiliation_string': '‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033056656', 'display_name': 'Ying Yao', 'orcid': 'https://orcid.org/0000-0003-0697-1820'}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ying Yao', 'raw_affiliation_strings': ['‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,'], 'affiliations': [{'raw_affiliation_string': '‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082766981', 'display_name': 'M. Féchir', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Marcel Fechir', 'raw_affiliation_strings': ['‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,'], 'affiliations': [{'raw_affiliation_string': '‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064206049', 'display_name': 'Huige Li', 'orcid': 'https://orcid.org/0000-0003-3458-7391'}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Förstermann', 'raw_affiliation_strings': ['‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,'], 'affiliations': [{'raw_affiliation_string': '‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047521943', 'display_name': 'Hartmut Kleinert', 'orcid': 'https://orcid.org/0000-0003-2202-3548'}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hartmut Kleinert', 'raw_affiliation_strings': ['‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,'], 'affiliations': [{'raw_affiliation_string': '‡Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany,', 'institution_ids': ['https://openalex.org/I197323543']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2910, 'currency': 'USD', 'value_usd': 2910, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.224, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.748647, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '287', 'issue': '1', 'first_page': '106', 'last_page': '115'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13483', 'display_name': 'Medicinal Properties of Echinacea Species', 'score': 0.9618, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11204', 'display_name': 'Calcium Signaling and Ion Channels in Sensation', 'score': 0.9499, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cytochalasin-d', 'display_name': 'Cytochalasin D', 'score': 0.5537603}, {'id': 'https://openalex.org/keywords/profilin', 'display_name': 'Profilin', 'score': 0.53730714}, {'id': 'https://openalex.org/keywords/antioxidant-activity', 'display_name': 'Antioxidant Activity', 'score': 0.451457}, {'id': 'https://openalex.org/keywords/ap-1-transcription-factor', 'display_name': 'AP-1 transcription factor', 'score': 0.43155026}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.77074546}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.7502073}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.7221483}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6500126}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.579528}, {'id': 'https://openalex.org/C2776041460', 'wikidata': 'https://www.wikidata.org/wiki/Q5201339', 'display_name': 'Cytochalasin D', 'level': 4, 'score': 0.5537603}, {'id': 'https://openalex.org/C203253989', 'wikidata': 'https://www.wikidata.org/wiki/Q419052', 'display_name': 'Profilin', 'level': 5, 'score': 0.53730714}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.47038427}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4317882}, {'id': 'https://openalex.org/C102280478', 'wikidata': 'https://www.wikidata.org/wiki/Q3270441', 'display_name': 'AP-1 transcription factor', 'level': 4, 'score': 0.43155026}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17287862}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16378203}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.14797625}], 'mesh': [{'descriptor_ui': 'D008841', 'descriptor_name': 'Actin Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D047630', 'descriptor_name': 'Depsipeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008841', 'descriptor_name': 'Actin Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008841', 'descriptor_name': 'Actin Cytoskeleton', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015638', 'descriptor_name': 'Cytochalasin D', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015638', 'descriptor_name': 'Cytochalasin D', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026362', 'descriptor_name': 'Serum Response Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D026362', 'descriptor_name': 'Serum Response Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026362', 'descriptor_name': 'Serum Response Factor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D026362', 'descriptor_name': 'Serum Response Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053778', 'descriptor_name': 'Thiazolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-4827(03)00129-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132505712', 'display_name': 'Experimental Cell Research', 'issn_l': '0014-4827', 'issn': ['0014-4827', '1090-2422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12799187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1560179018', 'https://openalex.org/W1581583867', 'https://openalex.org/W1692854040', 'https://openalex.org/W1909400967', 'https://openalex.org/W1971438724', 'https://openalex.org/W1978039775', 'https://openalex.org/W1984210761', 'https://openalex.org/W1986178012', 'https://openalex.org/W1992553517', 'https://openalex.org/W1994965373', 'https://openalex.org/W1996639040', 'https://openalex.org/W2013143107', 'https://openalex.org/W2023687572', 'https://openalex.org/W2028839438', 'https://openalex.org/W2032034078', 'https://openalex.org/W2037548392', 'https://openalex.org/W2040720194', 'https://openalex.org/W2046993758', 'https://openalex.org/W2054863219', 'https://openalex.org/W2056077806', 'https://openalex.org/W2056736540', 'https://openalex.org/W2062093468', 'https://openalex.org/W2066506893', 'https://openalex.org/W2066649179', 'https://openalex.org/W2080169215', 'https://openalex.org/W2093101675', 'https://openalex.org/W2111778006', 'https://openalex.org/W2113580903', 'https://openalex.org/W2129250847', 'https://openalex.org/W2131662040', 'https://openalex.org/W2132823860', 'https://openalex.org/W2134172294', 'https://openalex.org/W2134812217', 'https://openalex.org/W2147923435', 'https://openalex.org/W2150827129', 'https://openalex.org/W2153628852', 'https://openalex.org/W2156103849', 'https://openalex.org/W2182354338', 'https://openalex.org/W2328331191', 'https://openalex.org/W2402146733', 'https://openalex.org/W2493200454', 'https://openalex.org/W4294216491'], 'related_works': ['https://openalex.org/W4307905277', 'https://openalex.org/W3158574716', 'https://openalex.org/W3127051863', 'https://openalex.org/W2594707584', 'https://openalex.org/W2158044026', 'https://openalex.org/W2104622316', 'https://openalex.org/W2074318844', 'https://openalex.org/W2018466181', 'https://openalex.org/W1511563935', 'https://openalex.org/W131757845'], 'abstract_inverted_index': {'Rho': [0, 23, 56, 185], 'proteins': [1, 24], '(Rho,': [2], 'Rac,': [3], 'Cdc': [4], '42)': [5], 'are': [6, 115], 'known': [7], 'to': [8, 166], 'control': [9], 'the': [10, 13, 31, 65, 79, 135, 139, 153, 170, 176, 189, 194], 'organization': [11], 'of': [12, 22, 52, 64, 71, 78, 108, 113, 138, 172, 188, 196], 'actin': [14, 59, 66, 80, 105, 140, 190], 'cytoskeleton': [15, 33, 67, 81, 191], 'as': [16, 18, 103], 'well': [17], 'gene': [19, 109, 129], 'expression.': [20, 74, 92, 110, 158], 'Inhibition': [21], 'by': [25, 50, 82, 175], 'Clostridium': [26], 'difficile': [27], 'toxin': [28], 'B': [29], 'disrupted': [30], 'F-actin': [32], 'and': [34, 68, 126], 'enhanced': [35, 89], 'cytokine-induced': [36, 72, 90], 'inducible': [37], 'nitric': [38], 'oxide': [39], 'synthase': [40], '(iNOS)': [41], 'expression': [42, 130, 174, 195], 'in': [43, 131, 169], 'human': [44, 144, 197], 'epithelial': [45], 'cells.': [46, 133], 'Also': [47], 'specific': [48], 'inhibition': [49], 'Y-27632': [51], 'p160ROCK,': [53], 'which': [54], 'mediates': [55], 'effects': [57, 164], 'on': [58, 143, 155], 'fibers,': [60], 'caused': [61], 'a': [62, 69], 'disruption': [63, 77], 'superinduction': [70], 'iNOS': [73, 91, 145, 156, 173], 'Accordingly,': [75], 'direct': [76], 'cytochalasin': [83], 'D,': [84], 'latrunculin': [85], 'B,': [86], 'or': [87], 'jasplakinolide': [88], 'The': [93], 'transcription': [94], 'factor': [95, 98], 'serum': [96], 'response': [97], '(SRF)': [99], 'has': [100], 'been': [101], 'described': [102], 'mediating': [104], 'cytoskeleton-dependent': [106], 'regulation': [107, 171], 'Direct': [111], 'targets': [112], 'SRF': [114], 'activating': [116], 'protein': [117], '1': [118], '(AP1)-dependent': [119], 'genes.': [120], 'All': [121], 'compounds': [122, 142], 'used': [123], 'inhibited': [124], 'SRF-': [125], 'AP1-dependent': [127], 'reporter': [128], 'DLD-1': [132], 'However,': [134], 'enhancing': [136], 'effect': [137, 154], 'cytoskeleton-disrupting': [141], 'promoter': [146], 'activity': [147], 'was': [148], 'much': [149], 'less': [150], 'pronounced': [151], 'than': [152], 'mRNA': [157], 'Therefore,': [159], 'besides': [160], 'transcriptional': [161], 'mechanisms,': [162], 'posttranscriptional': [163], 'seem': [165], 'be': [167], 'involved': [168], 'above': [177], 'compounds.': [178], 'In': [179], 'conclusion,': [180], 'our': [181], 'data': [182], 'suggest': [183], 'that': [184], 'protein-mediated': [186], 'changes': [187], 'negatively': [192], 'modulate': [193], 'iNOS.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1511563935', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-25T22:28:56.607101', 'created_date': '2016-06-24'}