Title: The Role of IL‐12 in Regulation of T Helper Cell Subsets in Vivo
Abstract: Annals of the New York Academy of SciencesVolume 795, Issue 1 p. 250-256 The Role of IL-12 in Regulation of T Helper Cell Subsets in Vivo Lessons from Experimental Cutaneous Leishmaniasisa PHILLIP SCOTT, PHILLIP SCOTT Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorBRIAN HONDOWICZ, BRIAN HONDOWICZ Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorASHLYN EATON, ASHLYN EATON Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorTANYA SCHARTON-KERSTEN, TANYA SCHARTON-KERSTEN Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this author PHILLIP SCOTT, PHILLIP SCOTT Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorBRIAN HONDOWICZ, BRIAN HONDOWICZ Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorASHLYN EATON, ASHLYN EATON Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this authorTANYA SCHARTON-KERSTEN, TANYA SCHARTON-KERSTEN Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street Philadelphia, Pennsylvania 19104Search for more papers by this author First published: October 1996 https://doi.org/10.1111/j.1749-6632.1996.tb52674.xCitations: 7 a This work was supported by National Institutes of Health Grants AI30073 and AI35914. Scott is the recipient of a Burroughs Wellcome New Investigator Award in Molecular Parasitology. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Mosmann, T. R. & R. L. Coffman. 1989. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145– 173. 2 Hsieh, C.-S., S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra & K. M. Murphy. 1993. Development of Thl CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260: 547– 549. 3 Scott, P. 1995. T helper cell development and regulation in experimental cutaneous leishmaniasis. Chem. Immunol. 63:. 4 Scott, P. 1991. IFN-gamma modulates the early development of Thl and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147, 3149– 3155. 5 Scharton, T. M. & P. Scott. 1993. Natural killer cells are a source of IFN-γ that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178: 567– 577. 6 Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins & R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J. Exp. Med. 171: 115– 127. 7 Scott, P. & G. Trinchieri. 1995. The role of NK cells in host-parasite interactions. Cur. Op. Immunol. In press. 8 Afonso, L. C. C., T. M. Scharton, L. Q. Vierira, M. Wysocka, G. Trinchieri & P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263: 235– 237. 9 Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser & M. K. Gately. 1993. Recombinant Interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177: 1505– 1509. 10 Sypek, J. P., C. L. Chung, S. E. H. Mayor, et al. 1993. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Thl immune response. J. Exp. Med. 177: 1797– 1802. 11 Reiner, S. L., S. Zheng, Z.-E. Wang, L. Stowring & R. M. Locksley. 1994. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J. Exp. Med. 179: 447– 456. 12 Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri & P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154: 5320– 5330. 13 Heinzel, F. P., R. M. Rerko, F. Ahmed & E. Pearlman. 1995. Endogenous IL-12 is required for control of Th2 cytokine responses. J. Immunol. 155: 730– 739. 14 Stenger, S., H. Thuring, M. Rollinghoff & C. Bogdan. 1994. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 180: 783– 793. 15 Seder, R. A., R. Gazzinelli, A. Sher & W. E. Paul. 1993. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. U.S.A. 90: 10188– 10192. 16 Nabors, G. S., L. C. C. Afonso, J. P. Farrell & P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin-12 and pentostam. Proc. Natl. Acad. Sci. USA 92: 3142– 3146. 17 Powrie, F., R. Correa-Oliveira, S. Mauze & R. L. Coffman. 1994. Regulatory interactions between CD45RBhigh| and CD45RBloW| CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179: 589– 600. 18 Manetti, R., P. Parronchi, M. G. Giudizi, et al. 1993. Natural killer cell stimulatory factor (NKSF/IL-12) induces Thl-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177: 1199– 1204. Citing Literature Volume795, Issue1Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory CytokineOctober 1996Pages 250-256 ReferencesRelatedInformation
Publication Year: 1996
Publication Date: 1996-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 9
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