Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W13935827', 'doi': None, 'title': 'The role of the E-cadherin/catenin complex in gastrointestinal cancer.', 'display_name': 'The role of the E-cadherin/catenin complex in gastrointestinal cancer.', 'publication_year': 2000, 'publication_date': '2000-02-29', 'ids': {'openalex': 'https://openalex.org/W13935827', 'mag': '13935827', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10692769'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10692769', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073527562', 'display_name': 'Philip R. Debruyne', 'orcid': 'https://orcid.org/0000-0001-5438-9697'}, 'institutions': [{'id': 'https://openalex.org/I2801227569', 'display_name': 'Ghent University Hospital', 'ror': 'https://ror.org/00xmkp704', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801227569']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'P Debruyne', 'raw_affiliation_strings': ['Department of Radiotherapy and Nuclear Medicine, University Hospital Gent, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiotherapy and Nuclear Medicine, University Hospital Gent, Belgium.', 'institution_ids': ['https://openalex.org/I2801227569']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084837815', 'display_name': 'Stefan Vermeulen', 'orcid': 'https://orcid.org/0000-0003-3710-800X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S Vermeulen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112714892', 'display_name': 'M. Mareel', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M Mareel', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.772, 'has_fulltext': False, 'cited_by_count': 59, 'citation_normalized_percentile': {'value': 0.824487, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '62', 'issue': '4', 'first_page': '393', 'last_page': '402'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9294, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9294, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9198, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adenomatous-polyposis-coli', 'display_name': 'Adenomatous polyposis coli', 'score': 0.4740058}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6407746}, {'id': 'https://openalex.org/C30145163', 'wikidata': 'https://www.wikidata.org/wiki/Q384104', 'display_name': 'Catenin', 'level': 4, 'score': 0.5544615}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5481423}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.49942255}, {'id': 'https://openalex.org/C2778237340', 'wikidata': 'https://www.wikidata.org/wiki/Q14883378', 'display_name': 'Adenomatous polyposis coli', 'level': 4, 'score': 0.4740058}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.47052872}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4688063}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.44348416}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43026283}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.41529107}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.3061635}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.28344482}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.28201425}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.27723902}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.2704693}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23837337}], 'mesh': [{'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005770', 'descriptor_name': 'Gastrointestinal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005770', 'descriptor_name': 'Gastrointestinal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10692769', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W582405081', 'https://openalex.org/W2790230828', 'https://openalex.org/W2156130533', 'https://openalex.org/W2136820777', 'https://openalex.org/W2132273568', 'https://openalex.org/W2125814878', 'https://openalex.org/W2090606368', 'https://openalex.org/W2065191902', 'https://openalex.org/W2064771994', 'https://openalex.org/W1987547578'], 'abstract_inverted_index': {'Cancer': [0], 'is': [1, 33, 70, 77, 103, 108, 136, 169, 229], 'a': [2, 44, 78, 83, 199, 210, 288], 'genetic': [3], 'disease.': [4], 'The': [5, 131, 364], 'unstable': [6, 190], 'genome': [7], 'of': [8, 25, 29, 40, 48, 67, 133, 146, 193, 224, 232, 247, 254, 258, 263, 271, 277, 280, 290, 293, 320, 324, 342, 349, 370, 373, 390, 398, 420, 424, 430], 'cancer': [9, 50, 160, 217], 'cells': [10, 51, 54, 192], 'causes': [11], 'tumour': [12, 352], 'progression': [13, 319], 'through': [14, 139, 144], 'multiple': [15], 'alterations': [16], 'in': [17, 37, 60, 72, 113, 118, 238, 317, 332, 344, 356, 360, 378], 'suppressor': [18, 172, 353], 'and': [19, 27, 55, 101, 268, 311, 347, 375], 'promoter': [20], 'genes,': [21], 'leading': [22], 'to': [23, 94, 120, 148, 180, 405], 'loss': [24], 'homeostatic': [26], 'gain': [28], 'oncogenic': [30], 'functions.': [31], 'Invasion': [32], 'the': [34, 38, 49, 57, 73, 95, 123, 149, 154, 164, 175, 178, 181, 189, 214, 233, 251, 274, 281, 304, 318, 325, 339, 350, 357, 368, 387, 406, 415, 421, 428], 'critical': [35], 'step': [36], 'acquisition': [39], 'malignancy.': [41], 'It': [42], 'implicates': [43], 'continuous': [45], 'molecular': [46], 'conversation': [47], 'with': [52, 56, 85, 287], 'other': [53], 'extracellular': [58, 275], 'matrix': [59], 'which': [61, 212, 242, 294], 'adhesion': [62, 100, 141], 'molecules': [63], 'are': [64, 243, 309], 'crucial.': [65], 'One': [66], 'these,': [68], 'E-cadherin,': [69, 255], 'discussed': [71], 'present': [74], 'review.': [75], 'E-cadherin': [76, 93, 267, 326, 343, 374, 399], 'transmembrane': [79], 'glycoprotein': [80], 'that': [81, 122, 396], 'forms': [82], 'complex': [84, 125, 211, 235, 283], 'cytoplasmic': [86], 'proteins,': [87], 'termed': [88], 'catenins': [89, 401], 'because': [90], 'they': [91], 'link': [92], 'actin': [96], 'cytoskeleton.': [97], 'E-cadherin/catenin-mediated': [98, 422], 'intercellular': [99], 'communication': [102], 'mainly': [104], 'homophylic': [105], 'homotypic.': [106], 'There': [107], 'compelling': [109], 'evidence': [110], 'from': [111, 177, 273, 418], 'experiments': [112], 'vitro': [114], 'as': [115, 117, 127], 'well': [116], 'vivo': [119], 'accept': [121], 'E-cadherin/catenin': [124, 234, 282, 305], 'acts': [126], 'an': [128, 170, 195], 'invasion': [129, 171, 425], 'suppressor.': [130], 'mechanism': [132], 'this': [134, 312], 'action': [135], 'not': [137], 'only': [138], 'cell-cell': [140], 'but': [142], 'also': [143, 207], 'transduction': [145], 'signals': [147], "cell's": [150], 'motility': [151], 'system.': [152], 'In': [153, 220, 299, 412], 'replication': [155], 'error': [156], 'positive': [157], 'human': [158, 301], 'colon': [159], 'cell': [161, 260], 'line': [162], 'HCT-8,': [163], 'alpha': [165], 'E-catenin': [166], 'gene': [167, 244, 354], 'CTNNA1': [168, 197], 'gene.': [173, 205], 'Here,': [174], 'transition': [176], 'non-invasive': [179, 191], 'invasive': [182], 'state': [183], 'was': [184], 'prevented': [185], 'by': [186], 'introduction': [187], 'into': [188], 'either': [194, 225], 'extra': [196], 'or': [198, 227, 306, 355, 400], 'wild': [200], 'type': [201], 'hMSH6': [202], 'mismatch': [203], 'repair': [204], 'beta-catenin': [206, 228, 358], 'participates': [208], 'at': [209], 'comprises': [213], 'adenomatous': [215], 'polyposis': [216], 'protein': [218], 'APC.': [219], 'colorectal': [221, 362], 'cancer,': [222], 'mutation': [223], 'APC': [226, 351], 'oncogenic.': [230], 'Downregulation': [231], 'may': [236], 'occur': [237, 331], 'several': [239], 'ways': [240], 'amongst': [241], 'mutations,': [245, 330], 'methylation': [246, 337], "5'CpG": [248], 'dinucleotides': [249], 'within': [250], 'promotor': [252, 340], 'region': [253, 341], 'tyrosine': [256], 'phosphorylation': [257], 'beta-catenin,': [259], 'surface': [261], 'expression': [262, 377], 'proteoglycans': [264], 'sterically': [265], 'hindering': [266], 'proteolytic': [269], 'release': [270], 'fragments': [272], 'part': [276], 'E-cadherin.': [278], 'Upregulation': [279], 'has': [284], 'been': [285], 'realized': [286], 'series': [289], 'agents,': [291], 'some': [292], 'can': [295], 'be': [296, 427], 'used': [297, 408], 'therapeutically.': [298], 'most': [300, 361], 'gastrointestinal': [302, 379], 'cancers': [303], 'related': [307], 'complexes': [308], 'disturbed': [310], 'underscores': [313], 'their': [314], 'pivotal': [315], 'role': [316], 'these': [321], 'tumours.': [322], 'Mutations': [323], 'gene,': [327], 'including': [328], 'germline': [329], 'diffuse': [333], 'gastric': [334], 'carcinoma,': [335], 'CpG': [336], 'around': [338], 'hepatocellular': [345], 'carcinomas': [346], 'mutations': [348], 'oncogene': [359], 'cancers.': [363, 380], 'literature': [365], 'agrees': [366], 'about': [367, 386], 'disturbance': [369], 'immunohistochemical': [371, 392], 'patterns': [372], 'catenin': [376], 'Conflicting': [381], 'opinions': [382], 'do,': [383], 'however,': [384], 'exist': [385], 'prognostic': [388, 403], 'value': [389, 404], 'such': [391], 'aberrations.': [393], 'We': [394], 'doubt': [395], 'immunohistochemistry': [397], 'add': [402], 'already': [407], 'histological': [409], 'grading': [410], 'systems.': [411], 'our': [413], 'opinion': [414], 'major': [416], 'benefit': [417], 'understanding': [419], 'pathways': [423], 'will': [426], 'development': [429], 'new': [431], 'anti-invasive': [432], 'treatment': [433], 'strategies.': [434]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W13935827', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-24T11:04:32.278332', 'created_date': '2016-06-24'}